日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Biochemical and biophysical analyses of hypoxia sensing prolyl hydroxylases from Dictyostelium discoideum and Toxoplasma gondii

对盘基网柄菌和弓形虫的缺氧感应脯氨酰羟化酶进行生物化学和生物物理分析

Liu, Tongri; Abboud, Martine I; Chowdhury, Rasheduzzaman; Tumber, Anthony; Hardy, Adam P; Lippl, Kerstin; Lohans, Christopher T; Pires, Elisabete; Wickens, James; McDonough, Michael A; West, Christopher M; Schofield, Christopher J

Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors

4-羟基嘧啶类HIF脯氨酰羟化酶结构域抑制剂的构效关系及晶体学研究

Holt-Martyn, James P; Chowdhury, Rasheduzzaman; Tumber, Anthony; Yeh, Tzu-Lan; Abboud, Martine I; Lippl, Kerstin; Lohans, Christopher T; Langley, Gareth W; Figg, William Jr; McDonough, Michael A; Pugh, Christopher W; Ratcliffe, Peter J; Schofield, Christopher J

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates.

重组 HIF 脯氨酰羟化酶 (PHD) 对已报道的非 HIF 底物缺乏活性

Cockman Matthew E, Lippl Kerstin, Tian Ya-Min, Pegg Hamish B, Figg William D Jnr, Abboud Martine I, Heilig Raphael, Fischer Roman, Myllyharju Johanna, Schofield Christopher J, Ratcliffe Peter J

Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors

螺[4.5]癸酮脯氨酰羟化酶结构域抑制剂的研究

Holt-Martyn, James P; Tumber, Anthony; Rahman, Mohammed Z; Lippl, Kerstin; Figg, William Jr; McDonough, Michael A; Chowdhury, Rasheduzzaman; Schofield, Christopher J

2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2

2-酮戊二酸调节羟基化缺氧诱导因子与脯氨酰羟化酶结构域2的结合

Abboud, Martine I; McAllister, Tom E; Leung, Ivanhoe K H; Chowdhury, Rasheduzzaman; Jorgensen, Christian; Domene, Carmen; Mecinović, Jasmin; Lippl, Kerstin; Hancock, Rebecca L; Hopkinson, Richard J; Kawamura, Akane; Claridge, Timothy D W; Schofield, Christopher J

Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases.

通过抑制缺氧诱导因子(HIF)脯氨酰羟化酶和天冬酰胺羟化酶来调节对缺氧的转录反应

Chan Mun Chiang, Ilott Nicholas E, Schödel Johannes, Sims David, Tumber Anthony, Lippl Kerstin, Mole David R, Pugh Christopher W, Ratcliffe Peter J, Ponting Chris P, Schofield Christopher J