日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC-Derived Cortical Organoids.

自噬激活剂可使异常的 Tau 蛋白稳态正常化,并挽救人类家族性阿尔茨海默病 iPSC 衍生皮质类器官中的突触。

Labra Sergio R, Compher Jadon, Prabhavalkar Akhil, Almaraz Mireya, Cedeño Kwong Claudia, Baal Christine, Talantova Maria, Dolatabadi Nima, Piña-Sanz Julian, Wang Yubo, Yoon Leonard, Ghatak Swagata, Gao Zi, Zhang Yuting, Trudler Dorit, Massey Lynee, Lin Wei, Balistreri Anthony, Bula Michael, Schork Nicholas J, Mondala Tony S, Head Steven R, Kelly Jeffery W, Lipton Stuart A

Aberrant Protein S-Nitrosylation Mimics the Effect of Rare Genetic Mutations in Neurodegenerative Diseases

异常蛋白质S-亚硝基化模拟罕见基因突变在神经退行性疾病中的作用

Wang, Yubo; Lipton, Stuart A

Proteome-wide profiling of S-nitrosylated proteins using the SNOTRAP probe and mass spectrometry-based detection

利用SNOTRAP探针和基于质谱的检测方法对S-亚硝基化蛋白进行全蛋白质组分析

Yang, Hongmei; Amal, Haitham; Tannenbaum, Steven R; Lipton, Stuart A

Mutant prion protein enhances NMDA receptor activity, activates PKC, and triggers rapid excitotoxicity in mice

突变朊病毒蛋白增强NMDA受体活性,激活蛋白激酶C (PKC),并在小鼠中引发快速兴奋性毒性。

Lin, Joie; Callender, Julia A; Mayfield, Joshua E; McClatchy, Daniel B; Ojeda-Juárez, Daniel; Pourhamzeh, Mahsa; Soldau, Katrin; Kurt, Timothy D; Danque, Garrett A; Khuu, Helen; Ronson, Josephina E; Pizzo, Donald P; Du, Yixing; Gruber, Maxwell A; Sevillano, Alejandro M; Wang, Jin; Orrú, Christina D; Chen, Joy; Funk, Gail; Aguilar-Calvo, Patricia; Aulston, Brent D; Roy, Subhojit; Rho, Jong M; Bui, Jack D; Newton, Alexandra C; Lipton, Stuart A; Caughey, Byron; Patrick, Gentry N; Doré, Kim; Yates, John R 3rd; Sigurdson, Christina J

Dysregulation of miRNA expression and excitation in MEF2C autism patient hiPSC-neurons and cerebral organoids.

MEF2C自闭症患者hiPSC神经元和脑类器官中miRNA表达和兴奋失调

Trudler Dorit, Ghatak Swagata, Bula Michael, Parker James, Talantova Maria, Luevanos Melissa, Labra Sergio, Grabauskas Titas, Noveral Sarah Moore, Teranaka Mayu, Schahrer Emily, Dolatabadi Nima, Bakker Clare, Lopez Kevin, Sultan Abdullah, Patel Parth, Chan Agnes, Choi Yongwook, Kawaguchi Riki, Stankiewicz Pawel, Garcia-Bassets Ivan, Kozbial Piotr, Rosenfeld Michael G, Nakanishi Nobuki, Geschwind Daniel H, Chan Shing Fai, Lin Wei, Schork Nicholas J, Ambasudhan Rajesh, Lipton Stuart A

S-Nitrosylation of CRTC1 in Alzheimer's disease impairs CREB-dependent gene expression induced by neuronal activity

阿尔茨海默病中CRTC1的S-亚硝基化会损害神经元活动诱导的CREB依赖性基因表达。

Zhang, Xu; Vlkolinsky, Roman; Wu, Chongyang; Dolatabadi, Nima; Scott, Henry; Prikhodko, Olga; Zhang, Andrew; Blanco, Mayra; Lang, Nhi; Piña-Crespo, Juan; Nakamura, Tomohiro; Roberto, Marisa; Lipton, Stuart A

Redox modulation of the complement cascade contributes to synapse loss in Alzheimer's disease

补体级联反应的氧化还原调节导致阿尔茨海默病中的突触丢失

Oh, Chang-Ki; Wang, Yubo; Lipton, Stuart A

Gasotransmitter signaling in the brain: New frontiers for therapeutics

大脑中的气体递质信号传导:治疗学的新前沿

Paul, Bindu D; Ignarro, Louis J; Lipton, Stuart A

Aberrant S-nitrosylation in the TCA cycle contributes to mitochondrial dysfunction, energy compromise, and synapse loss in neurodegenerative diseases

三羧酸循环中异常的S-亚硝基化会导致神经退行性疾病中的线粒体功能障碍、能量代谢受损和突触丢失。

Nakamura, Tomohiro; Sharma, Anamika; Lipton, Stuart A

diAcCA, a Pro-Drug for Carnosic Acid That Activates the Nrf2 Transcriptional Pathway, Shows Efficacy in the 5xFAD Transgenic Mouse Model of Alzheimer's Disease.

diAcCA 是一种激活 Nrf2 转录通路的肌肽酸前药,在 5xFAD 阿尔茨海默病转基因小鼠模型中显示出疗效

Banerjee Piu, Wang Yubo, Carnevale Lauren N, Patel Parth, Raspur Charlene K, Tran Nancy, Zhang Xu, Natarajan Ravi, Roberts Amanda J, Baran Phil S, Lipton Stuart A