日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dual promoter-enhancer activities reflect a unified regulatory logic

双重启动子-增强子活性反映了一种统一的调控逻辑

Paramo, Mauricio I; Leung, Alden King-Yung; Shah, Sagar R; Zhang, Junke; Tippens, Nathaniel D; Liang, Jin; Yao, Li; Jin, Yiyang; Pan, Xiuqi; Ozer, Abdullah; Lis, John T; Yu, Haiyuan

Cell-type-specific RNA polymerase II activity maps in intact tissues provide a gateway to mammalian gene regulatory mechanisms in vivo.

完整组织中细胞类型特异性 RNA 聚合酶 II 活性图谱为了解哺乳动物体内基因调控机制提供了途径。

Chovatiya Gopal, Huang Sean Y, Wang Alex B, Versluis Philip, Bai Chris K, DeBerardine Michael, Liao Yu-Ching, Ray Judhajeet, Ozer Abdullah, Lis John T, Tumbar Tudorita

Comprehensive evaluation of diverse massively parallel reporter assays to functionally characterize human enhancers genome-wide

对多种大规模并行报告基因检测方法进行全面评估,以从全基因组范围内表征人类增强子的功能。

Zhang, Junke; Leung, Alden King-Yung; Zhu, Yutong; Yao, Li; Willis, Avery; Pan, Xiuqi; Ozer, Abdullah; Zhou, Zhou; Siklenka, Keith; Barrera, Alejandro; Liang, Jin; Tippens, Nathaniel D; Reddy, Timothy E; Lis, John T; Yu, Haiyuan

The regulatory landscape of nascent transcription in human health and disease

人类健康和疾病中新生转录的调控格局

Shah, Sagar R; Chen, You; Leung, Alden K; Navarro, Priscila V Castilho; Paramo, Mauricio I; Gupta, Juhi; Gurumurthy, Aishwarya; Fite, Rebuma Firdessa; Weimer, Annika K; Du, Qian; Mohyeldin, Ahmed M; Egli, Dieter; Creusot, Remi J; Ryan, Russell J H; Snyder, Michael P; Clark, Andrew G; Lis, John T; Yu, Haiyuan

High-resolution reconstruction of cell-type specific transcriptional regulatory processes from bulk sequencing samples

利用批量测序样本对细胞类型特异性转录调控过程进行高分辨率重建

Yao, Li; Shah, Sagar R; Ozer, Abdullah; Zhang, Junke; Pan, Xiuqi; Xia, Tianyu; Fangal, Vrushali D; Leung, Alden King-Yung; Wei, Meihan; Lis, John T; Yu, Haiyuan

Identification of human RNA Polymerase II interactors at early stages of transcription.

鉴定人类 RNA 聚合酶 II 在转录早期阶段的相互作用蛋白。

Ozer Abdullah, Kang Jin Joo, Tang Yuliang, Yugandhar Kumar, Yu Sun, DeBerardine Michael D, Omar Karim, Lis John T, Yu Haiyuan

Simultaneous measurement of intrinsic promoter and enhancer potential reveals principles of functional duality and regulatory reciprocity.

同时测量内在启动子和增强子潜能,揭示了功能二元性和调控互惠的原理

Paramo Mauricio I, Leung Alden King-Yung, Shah Sagar R, Zhang Junke, Tippens Nathaniel D, Liang Jin, Yao Li, Jin Yiyang, Pan Xiuqi, Ozer Abdullah, Lis John T, Yu Haiyuan

Robust regulatory interplay of enhancers, facilitators, and promoters in a native chromatin context.

在天然染色质环境中,增强子、促进子和启动子之间存在着稳健的调控相互作用

Zhou Zhou, Li Albert, Zhang Junke, Yu Haiyuan, Ozer Abdullah, Lis John T

Live-cell imaging of RNA Pol II and elongation factors distinguishes competing mechanisms of transcription regulation.

RNA Pol II 和延伸因子的活细胞成像可以区分转录调控的竞争机制

Versluis Philip, Graham Thomas G W, Eng Vincent, Ebenezer Jonathan, Darzacq Xavier, Zipfel Warren R, Lis John T

The NELF pausing checkpoint mediates the functional divergence of Cdk9

NELF暂停检查点介导Cdk9的功能分化

DeBerardine, Michael; Booth, Gregory T; Versluis, Philip P; Lis, John T