日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

RXR nuclear receptor signaling modulates lipid metabolism and triggers lysosomal clearance of alpha-synuclein in neuronal models of synucleinopathy

RXR 核受体信号调节脂质代谢并触发突触核蛋白病神经元模型中 α-突触核蛋白的溶酶体清除

Arati Tripathi, Heba Alnakhala, Lisa Brontesi, Dennis Selkoe, Ulf Dettmer

Adding hydrophobicity or positive charges to the cytosolic half of the α-synuclein 3-11 helix increases membrane association and S129 phosphorylation

在 α-突触核蛋白 3-11 螺旋的胞质一半上添加疏水性或正电荷可增加膜结合和 S129 磷酸化

Kazuma Shimanaka, Bryan Shi, Lisa Brontesi, Heba Alnakhala, Vidyashree Jayanthi, Kanagaraj Subramanian, Nagendran Ramalingam, Arati Tripathi, Ulf Dettmer

Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity

动态生理性 α-突触核蛋白 S129 磷酸化由神经元活动驱动

Nagendran Ramalingam, Shan-Xue Jin #, Tim E Moors #, Luis Fonseca-Ornelas, Kazuma Shimanaka, Shi Lei, Hugh P Cam, Aurelia Hays Watson, Lisa Brontesi, Lai Ding, Dinc Yasat Hacibaloglu, Haiyang Jiang, Se Joon Choi, Ellen Kanter, Lei Liu, Tim Bartels, Silke Nuber, David Sulzer, Eugene V Mosharov, Weish

Dynamic reversibility of α-synuclein serine-129 phosphorylation is impaired in synucleinopathy models

在突触核蛋白病模型中,α-突触核蛋白丝氨酸129磷酸化的动态可逆性受损。

Nagendran Ramalingam ,Lisa Brontesi ,Shan-Xue Jin ,Dennis J Selkoe ,Ulf Dettmer

The effects of KTKEGV repeat motif and intervening ATVA sequence on α-synuclein solubility and assembly

KTKEGV 重复基序和中间 ATVA 序列对 α-突触核蛋白溶解度和组装的影响

Lisa Brontesi, Thibaut Imberdis, Nagendran Ramalingam, Ulf Dettmer

Excess membrane binding of monomeric alpha-, beta- and gamma-synuclein is invariably associated with inclusion formation and toxicity

单体 α-、β- 和 γ-突触核蛋白的过量膜结合必然与内含物形成和毒性有关

Tae-Eun Kim, Andrew J Newman, Thibaut Imberdis, Lisa Brontesi, Arati Tripathi, Nagendran Ramalingam, Saranna Fanning, Dennis Selkoe, Ulf Dettmer