日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

BET inhibition targets ABC-DLBCL constitutive B-cell receptor signaling through PAX5

BET 抑制通过 PAX5 靶向 ABC-DLBCL 组成型 B 细胞受体信号传导

Derek B Oien, Samanta Sharma, Maureen M Hattersley, Michelle DuPont, Steven W Criscione, Laura Prickett, Anne U Goeppert, Lisa Drew, Yi Yao, Jingwen Zhang, Ho Man Chan

Targeting MCL-1 dysregulates cell metabolism and leukemia-stroma interactions and resensitizes acute myeloid leukemia to BCL-2 inhibition

靶向 MCL-1 可失调细胞代谢和白血病-基质相互作用,并使急性髓系白血病对 BCL-2 抑制重新敏感

Bing Z Carter, Po Yee Mak, Wenjing Tao, Marc Warmoes, Philip L Lorenzi, Duncan Mak, Vivian Ruvolo, Lin Tan, Justin Cidado, Lisa Drew, Michael Andreeff

Targeting Bfl-1 via acute CDK9 inhibition overcomes intrinsic BH3-mimetic resistance in lymphomas

通过急性 CDK9 抑制靶向 Bfl-1 可克服淋巴瘤中内在的 BH3 模拟物耐药性

Scott Boiko, Theresa Proia, Maryann San Martin, Gareth P Gregory, Michelle Min Wu, Neeraj Aryal, Maureen Hattersley, Wenlin Shao, Jamal C Saeh, Stephen E Fawell, Ricky W Johnstone, Lisa Drew, Justin Cidado

Antisense oligonucleotide therapy reduces seizures and extends life span in an SCN2A gain-of-function epilepsy model

反义寡核苷酸疗法可减少 SCN2A 功能获得性癫痫模型中的癫痫发作并延长寿命

Melody Li, Nikola Jancovski, Paymaan Jafar-Nejad, Lisseth E Burbano, Ben Rollo, Kay Richards, Lisa Drew, Alicia Sedo, Jacqueline Heighway, Svenja Pachernegg, Armand Soriano, Linghan Jia, Todd Blackburn, Blaine Roberts, Alex Nemiroff, Kelley Dalby, Snezana Maljevic, Christopher A Reid, Frank Rigo, St

Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity

小分子AZD4635作为A2AR信号通路抑制剂,可恢复包括CD103+树突状细胞在内的免疫细胞功能,从而增强抗肿瘤免疫力。

Alexandra Borodovsky # ,Christine M Barbon # ,Yanjun Wang ,Minwei Ye ,Laura Prickett ,Dinesh Chandra ,Joseph Shaw ,Nanhua Deng ,Kris Sachsenmeier ,James D Clarke ,Bolan Linghu ,Giles A Brown ,James Brown ,Miles Congreve ,Robert Ky Cheng ,Andrew S Dore ,Edward Hurrell ,Wenlin Shao ,Richard Woessner ,Corinne Reimer ,Lisa Drew ,Stephen Fawell ,Alwin G Schuller ,Deanna A Mele

Biomarker-driven strategy for MCL1 inhibition in T-cell lymphomas

基于生物标志物的MCL1抑制策略在T细胞淋巴瘤中的应用

Raphael Koch ,Amanda L Christie ,Jennifer L Crombie ,Adam C Palmer ,Deborah Plana ,Kay Shigemori ,Sara N Morrow ,Alexandria Van Scoyk ,Wenchao Wu ,Elizabeth A Brem ,J Paul Secrist ,Lisa Drew ,Alwin G Schuller ,Justin Cidado ,Anthony Letai ,David M Weinstock

Targeting melanoma's MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors

针对黑色素瘤的 MCL1 偏向释放了 BRAF 和 ERK1/2 通路抑制剂的凋亡潜力

Matthew J Sale, Emma Minihane, Noel R Monks, Rebecca Gilley, Frances M Richards, Kevin P Schifferli, Courtney L Andersen, Emma J Davies, Mario Aladren Vicente, Eiko Ozono, Aleksandra Markovets, Jonathan R Dry, Lisa Drew, Vikki Flemington, Theresa Proia, Duncan I Jodrell, Paul D Smith, Simon J Cook

The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells

CUL5 泛素连接酶复合物介导肺癌细胞对 CDK9 和 MCL1 抑制剂的耐药性

Shaheen Kabir, Justin Cidado, Courtney Andersen, Cortni Dick, Pei-Chun Lin, Therese Mitros, Hong Ma, Seung Hyun Baik, Matthew A Belmonte, Lisa Drew, Jacob E Corn

Cyclin-Dependent Kinase-9 Is a Therapeutic Target in MYC-Expressing Diffuse Large B-Cell Lymphoma

细胞周期蛋白依赖性激酶 9 是 MYC 表达型弥漫大 B 细胞淋巴瘤的治疗靶点

Taylor Hashiguchi #, Nur Bruss #, Scott Best, Vi Lam, Olga Danilova, Cody J Paiva, Joelle Wolf, Erin W Gilbert, Craig Y Okada, Prabhjot Kaur, Lisa Drew, Justin Cidado, Peter Hurlin, Alexey V Danilov

AZ304, a novel dual BRAF inhibitor, exerts anti-tumour effects in colorectal cancer independently of BRAF genetic status

AZ304 是一种新型双重 BRAF 抑制剂,可在结直肠癌中发挥抗肿瘤作用,与 BRAF 基因状态无关

Rui Ma, Ling Xu, Xiujuan Qu, Xiaofang Che, Ye Zhang, Yibo Fan, Ce Li, Tianshu Guo, Kezuo Hou, Xuejun Hu, Lisa Drew, Minhui Shen, Tony Cheung, Yunpeng Liu