Susceptibility to systemic autoimmunity rather than the presence of the HLA-DR4 peptide binding domain alone leads to severe inflammatory arthritis following inhalation of crystalline silica
吸入结晶二氧化硅后,导致严重炎症性关节炎的并非仅仅是HLA-DR4肽结合域的存在,而是对系统性自身免疫的易感性。
期刊:Particle and Fibre Toxicology
影响因子:8.2
doi:10.1186/s12989-026-00662-z
Janssen, Lisa M F; de Ocampo, Caroline; Kono, Dwight H; Ronsmans, Steven; Ghosh, Manosij; Hoet, Peter H M; Pollard, K Michael; Mayeux, Jessica M