日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

ONC213: a novel strategy to resensitize resistant AML cells to venetoclax through induction of mitochondrial stress

ONC213：通过诱导线粒体应激使耐药 AML 细胞对维奈克拉重新敏感的新策略

期刊:Journal of Experimental & Clinical Cancer Research
影响因子:11.4
doi:10.1186/s13046-024-03267-6
Jenna L Carter, Yongwei Su, Eman T Al-Antary, Jianlei Zhao, Xinan Qiao, Guan Wang, Holly Edwards, Lisa Polin, Juiwanna Kushner, Sijana H Dzinic, Kathryn White, Steven A Buck, Maik Hüttemann, Joshua E Allen, Varun V Prabhu, Jay Yang, Jeffrey W Taub, Yubin Ge6
免疫
细胞生物学
其它细胞
发表日期：2025
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Genome-wide mapping of arsenic-activated Nrf2 reveals metabolic and epigenetic reprogramming in induced pluripotent stem cells

全基因组砷激活Nrf2定位揭示诱导多能干细胞的代谢和表观遗传重编程

期刊:Redox Biology
影响因子:10.7
doi:10.1016/j.redox.2025.103773
Akimasa Seno,Zhuoyue Bi,Lisa Polin,Ziqi Liu,Yiran Qiu,Wenxuan Zhang,Aashna Pawar,Chitra Thakur,Masaharu Seno,Ziwei Wang,Fei Chen
细胞生物学
代谢
发育与干细胞
表观遗传
干细胞
NRF2
发表日期：2025
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The Imipridone ONC213 Targets α-Ketoglutarate Dehydrogenase to Induce Mitochondrial Stress and Suppress Oxidative Phosphorylation in Acute Myeloid Leukemia

伊米吡酮 ONC213 靶向 α-酮戊二酸脱氢酶，诱导线粒体应激并抑制急性髓系白血病中的氧化磷酸化

期刊:Cancer Research
影响因子:12.5
doi:10.1158/0008-5472.CAN-23-2659
Yongwei Su ，Jenna L Carter ，Xinyu Li ，Yu Fukuda ，Ashley Gray ，John Lynch ，Holly Edwards ，Jun Ma ，Patrick Schreiner ，Lisa Polin ，Juiwanna Kushner ，Sijana H Dzinic ，Steven A Buck ，Shondra M Pruett-Miller ，Katie Hege-Hurrish ，Camenzind Robinson ，Xinan Qiao ，Shuang Liu ，Shuangshuang Wu ，Guan Wang ，Jing Li ，Joshua E Allen ，Varun V Prabhu ，Aaron D Schimmer ，Dhananjay Joshi ，Shiva Kalhor-Monfared ，Iain D G Watson ，Richard Marcellus ，Methvin B Isaac ，Rima Al-Awar ，Jeffrey W Taub ，Hai Lin ，John D Schuetz ，Yubin Ge
线粒体
白血病
信号转导
磷酸化
发表日期：2024
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Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer

线粒体和细胞浆一碳代谢是顺铂耐药卵巢癌中可靶向的代谢弱点

期刊:Molecular Cancer Therapeutics
影响因子:5.3
doi:10.1158/1535-7163.MCT-23-0550
Adrianne Wallace-Povirk, Carrie O'Connor, Aamod S Dekhne, Xun Bao, Md Junayed Nayeen, Mathew Schneider, Jade M Katinas, Jennifer Wong-Roushar, Seongho Kim, Lisa Polin, Jing Li, Jessica B Back, Charles E Dann 3rd, Aleem Gangjee, Zhanjun Hou, Larry H Matherly
代谢
卵巢癌
肿瘤细胞
发表日期：2024
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Senescence-associated secretory proteins induced in lung adenocarcinoma by extended treatment with dexamethasone enhance migration and activation of lymphocytes

地塞米松长期治疗诱导肺腺癌细胞产生衰老相关分泌蛋白，从而增强淋巴细胞的迁移和活化。

期刊:Cancer Immunology Immunotherapy
影响因子:8.1
doi:10.1007/s00262-022-03332-z
Prahlad Parajuli ，Rayna Rosati ，Hirva Mamdani ，Robert E Wright 3rd ，Zahin Hussain ，Aroma Naeem ，Sijana Dzinic ，Lisa Polin ，Navnath S Gavande ，Manohar Ratnam
肿瘤免疫
细胞生物学
衰老
Senescence
肿瘤
发表日期：2023
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Identification of actionable targets for breast cancer intervention using a diversity outbred mouse model

使用多样性杂交小鼠模型识别乳腺癌干预的可行目标

期刊:iScience
影响因子:4.6
doi:10.1016/j.isci.2023.106320
Jennifer B Jacob, Kuang-Chung Wei, Gerold Bepler, Joyce D Reyes, Andi Cani, Lisa Polin, Kathryn White, Seongho Kim, Nerissa Viola, Julie McGrath, Anthony Guastella, CongCong Yin, Qing-Shen Mi, Benjamin L Kidder, Kay-Uwe Wagner, Stuart Ratner, Victoria Phillips, Joanne Xiu, Prahlad Parajuli, Wei-Zen
肿瘤
乳腺癌
Mouse
发表日期：2023
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ATR inhibition overcomes platinum tolerance associated with ERCC1- and p53-deficiency by inducing replication catastrophe

ATR 抑制通过诱导复制灾难克服了与 ERCC1 和 p53 缺陷相关的铂耐受性

期刊:NAR Cancer
影响因子:3.4
doi:10.1093/narcan/zcac045
Joshua R Heyza, Elmira Ekinci, Jacob Lindquist, Wen Lei, Christopher Yunker, Vilvanathan Vinothkumar, Rachelle Rowbotham, Lisa Polin, Natalie G Snider, Eric Van Buren, Donovan Watza, Jessica B Back, Wei Chen, Hirva Mamdani, Ann G Schwartz, John J Turchi, Gerold Bepler, Steve M Patrick
信号转导
发表日期：2023
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Enhancing anti-AML activity of venetoclax by isoflavone ME-344 through suppression of OXPHOS and/or purine biosynthesis

异黄酮 ME-344 通过抑制 OXPHOS 和/或嘌呤生物合成增强维奈克拉的抗 AML 活性

期刊:
影响因子:
doi:10.21203/rs.3.rs-2843025/v1
Katie H Hurrish, Yongwei Su, Shraddha Patel, Cassandra L Ramage, Jenna L Carter, Holly Edwards, Steven A Buck, Sandra E Wiley, Maik Hüttemann, Lisa Polin, Juiwanna Kushner, Sijana H Dzinic, Kathryn White, Xun Bao, Jing Li, Jay Yang, Julie Boerner, Zhanjun Hou, Gheath Al-Atrash, Sergej N Konoplev, Jo
发表日期：2023
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Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment

在同源小鼠高级别浆液性卵巢癌模型中，吡咯并[2,3-d]嘧啶类抗叶酸靶向治疗及其对肿瘤微环境的影响

期刊:Scientific Reports
影响因子:3.8
doi:10.1038/s41598-022-14788-5
Adrianne Wallace-Povirk ，Lisa Rubinsak ，Agnes Malysa ，Sijana H Dzinic ，Manasa Ravindra ，Mathew Schneider ，James Glassbrook ，Carrie O'Connor ，Zhanjun Hou ，Seongho Kim ，Jessica Back ，Lisa Polin ，Robert T Morris ，Aleem Gangjee ，Heather Gibson ，Larry H Matherly
肿瘤微环境
卵巢癌
肿瘤免疫
肿瘤
发表日期：2022
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The combination of CUDC-907 and gilteritinib shows promising in vitro and in vivo antileukemic activity against FLT3-ITD AML

CUDC-907 与 gilteritinib 的组合在体外和体内对 FLT3-ITD AML 表现出良好的抗白血病活性

期刊:Blood Cancer Journal
影响因子:12.9
doi:10.1038/s41408-021-00502-7
Xinan Qiao, Jun Ma, Tristan Knight, Yongwei Su, Holly Edwards, Lisa Polin, Jing Li, Juiwanna Kushner, Sijana H Dzinic, Kathryn White, Jian Wang, Hai Lin, Yue Wang, Liping Wang, Guan Wang, Jeffrey W Taub, Yubin Ge
肿瘤
白血病
WB
发表日期：2021
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