Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation
野生型 sTREM2 可阻断 Aβ 聚集和神经毒性,但阿尔茨海默氏症 R47H 突变体会增加 Aβ 聚集
期刊:Journal of Biological Chemistry
影响因子:4
doi:10.1016/j.jbc.2021.100631
Anna Vilalta, Ye Zhou, Jean Sevalle, Jennifer K Griffin, Kanayo Satoh, David H Allendorf, Suman De, Mar Puigdellívol, Arturas Bruzas, Miguel A Burguillos, Roger B Dodd, Fusheng Chen, Yalun Zhang, Patrick Flagmeier, Lisa-Maria Needham, Masahiro Enomoto, Seema Qamar, James Henderson, Jochen Walter, Pa