日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

POLCAM: instant molecular orientation microscopy for the life sciences

POLCAM:用于生命科学的即时分子取向显微镜

Ezra Bruggeman, Oumeng Zhang, Lisa-Maria Needham, Markus Körbel, Sam Daly, Matthew Cheetham, Ruby Peters, Tingting Wu, Andrey S Klymchenko, Simon J Davis, Ewa K Paluch, David Klenerman, Matthew D Lew, Kevin O'Holleran, Steven F Lee

Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation

野生型 sTREM2 可阻断 Aβ 聚集和神经毒性,但阿尔茨海默氏症 R47H 突变体会增加 Aβ 聚集

Anna Vilalta, Ye Zhou, Jean Sevalle, Jennifer K Griffin, Kanayo Satoh, David H Allendorf, Suman De, Mar Puigdellívol, Arturas Bruzas, Miguel A Burguillos, Roger B Dodd, Fusheng Chen, Yalun Zhang, Patrick Flagmeier, Lisa-Maria Needham, Masahiro Enomoto, Seema Qamar, James Henderson, Jochen Walter, Pa

A Comparative Study of High-Contrast Fluorescence Lifetime Probes for Imaging Amyloid in Tissue

高对比度荧光寿命探针对组织淀粉样蛋白成像的比较研究

Felix Gorka, Sam Daly, Colin M Pearson, Edita Bulovaite, Yu P Zhang, Anoushka Handa, Seth G N Grant, Thomas N Snaddon, Lisa-Maria Needham, Steven F Lee

Rational design of a conformation-specific antibody for the quantification of Aβ oligomers

合理设计用于定量 Aβ 寡聚体的构象特异性抗体

Francesco A Aprile, Pietro Sormanni, Marina Podpolny, Shianne Chhangur, Lisa-Maria Needham, Francesco S Ruggeri, Michele Perni, Ryan Limbocker, Gabriella T Heller, Tomas Sneideris, Tom Scheidt, Benedetta Mannini, Johnny Habchi, Steven F Lee, Patricia C Salinas, Tuomas P J Knowles, Christopher M Dobs

FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells

FRET 增强的光稳定性可以改善哺乳动物活细胞中蛋白质和蛋白质复合物的单分子追踪

Srinjan Basu, Lisa-Maria Needham, David Lando, Edward J R Taylor, Kai J Wohlfahrt, Devina Shah, Wayne Boucher, Yi Lei Tan, Lawrence E Bates, Olga Tkachenko, Julie Cramard, B Christoffer Lagerholm, Christian Eggeling, Brian Hendrich, Dave Klenerman, Steven F Lee, Ernest D Laue

Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species

用于检测淀粉样蛋白聚集体和活性氧的双功能荧光探针

Lisa-Maria Needham, Judith Weber, James W B Fyfe, Omaru M Kabia, Dung T Do, Ewa Klimont, Yu Zhang, Margarida Rodrigues, Christopher M Dobson, Sonia Ghandi, Sarah E Bohndiek, Thomas N Snaddon, Steven F Lee