日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Deep mutational scanning of essential bacterial proteins can guide antibiotic development

对必需细菌蛋白的深度突变扫描可以指导抗生素的开发

Liselot Dewachter, Aaron N Brooks, Katherine Noon, Charlotte Cialek, Alia Clark-ElSayed, Thomas Schalck, Nandini Krishnamurthy, Wim Versées #, Wim Vranken #, Jan Michiels #0

Mutations in respiratory complex I promote antibiotic persistence through alterations in intracellular acidity and protein synthesis

呼吸复合物 I 的突变通过改变细胞内酸度和蛋白质合成来促进抗生素的持久性

Bram Van den Bergh, Hannah Schramke, Joran Elie Michiels, Tom E P Kimkes, Jakub Leszek Radzikowski, Johannes Schimpf, Silke R Vedelaar, Sabrina Burschel, Liselot Dewachter, Nikola Lončar, Alexander Schmidt, Tim Meijer, Maarten Fauvart, Thorsten Friedrich, Jan Michiels, Matthias Heinemann

Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

sCRilecs-seq 表明,耐阿莫西林的肺炎链球菌可以通过靶向甲羟戊酸途径重新敏感

Liselot Dewachter, Julien Dénéréaz, Xue Liu, Vincent de Bakker, Charlotte Costa, Mara Baldry, Jean-Claude Sirard, Jan-Willem Veening