日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors

结合晶体学片段筛选和深度突变扫描,可以发现寨卡病毒NS2B-NS3蛋白酶抑制剂。

Ni, Xiaomin; Richardson, R Blake; Godoy, Andre Schutzer; Ferla, Matteo P; Kikawa, Caroline; Scheen, Jenke; Hannon, William W; Capkin, Eda; Lahav, Noa; Balcomb, Blake H; Marples, Peter G; Fairhead, Michael; Wang, SiYi; Williams, Eleanor P; Tomlinson, Charles W E; Aschenbrenner, Jasmin C; Lithgo, Ryan M; Winokan, Max; Giroud, Charline; Dolci, Isabela; Fernandes, Rafaela Sachetto; Oliva, Glaucius; Chandran, Anu V; Xavier, Mary-Ann; Walsh, Martin A; Thompson, Warren; Bloom, Jesse D; Kenton, Nathaniel T; Lee, Alpha A; von Delft, Annette; Barr, Haim; Kirkegaard, Karla; Koekemoer, Lizbé; Fearon, Daren; Evans, Matthew J; von Delft, Frank

High-throughput crystallographic fragment screening of Zika virus NS3 Helicase

寨卡病毒NS3解旋酶的高通量晶体学片段筛选

Godoy, Andre Schutzer; Giroud, Charline; Mesquita, Nathalya C M R; Noske, Gabriela Dias; Gawriljuk, Victor Oliveira; Lithgo, Ryan M; Balcomb, Blake H; Aschenbrenner, Jasmin Cara; Tomlinson, Charles W E; Winokan, Max; Scheen, Jenke; MacDermott-Opeskin, Hugo; Marples, Peter George; Chandran, Anu V; Ni, Xiaomin; Thompson, Warren; Fairhead, Michael; Fearon, Daren; Koekemoer, Lizbé; Xavier, Mary-Ann Elvina; Walsh, Martin; Oliva, Glaucius; von Delft, Frank

Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis

明确半乳糖凝集素3介导的TGF-β1活化机制及其在肺纤维化中的作用

Jessica F Calver, Nimesh R Parmar, Gemma Harris, Ryan M Lithgo, Panayiota Stylianou, Fredrik R Zetterberg, Bibek Gooptu, Alison C Mackinnon, Stephen B Carr, Lee A Borthwick, David J Scott, Iain D Stewart, Robert J Slack, R Gisli Jenkins, Alison E John3

Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals

柯萨奇病毒A16 2A蛋白酶的晶体学片段筛选为开发广谱抗肠道病毒药物提供了新的契机

Lithgo, Ryan M; Tomlinson, Charles W E; Fairhead, Michael; Winokan, Max; Thompson, Warren; Wild, Conor; Aschenbrenner, Jasmin Cara; Balcomb, Blake H; Marples, Peter G; Chandran, Anu V; Golding, Mathew; Koekemoer, Lizbe; Williams, Eleanor P; Wang, SiYl; Ni, Xiaomin; MacLean, Elizabeth; Giroud, Charline; Godoy, Andre Schutzer; Xavier, Mary-Ann; Walsh, Martin; Fearon, Daren; von Delft, Frank

Identifying novel chemical matter against the Chikungunya virus nsP3 macrodomain through crystallographic fragment screening

通过晶体学片段筛选鉴定针对基孔肯雅病毒nsP3宏结构域的新型化学物质

Aschenbrenner, Jasmin C; de Godoy, Andre Schutzer; Fairhead, Michael; Tomlinson, Charles W E; Winokan, Max; Balcomb, Blake H; Capkin, Eda; Chandran, Anu V; Golding, Mathew; Koekemoer, Lizbe; Lithgo, Ryan M; Marples, Peter G; Ni, Xiaomin; Thompson, Warren; Wild, Conor; Xavier, Mary-Ann E; Fearon, Daren; von Delft, Frank

The adaptability of the ion-binding site by the Ag(I)/Cu(I) periplasmic chaperone SilF

Ag(I)/Cu(I)周质伴侣蛋白SilF对离子结合位点的适应性

Lithgo, Ryan M; Hanževački, Marko; Harris, Gemma; Kamps, Jos J A G; Holden, Ellie; Gianga, Tiberiu-Marius; Benesch, Justin L P; Jäger, Christof M; Croft, Anna K; Hussain, Rohannah; Hobman, Jon L; Orville, Allen M; Quigley, Andrew; Carr, Stephen B; Scott, David J

The antibiotic vancomycin induces complexation and aggregation of gastrointestinal and submaxillary mucins

抗生素万古霉素诱导胃肠道和颌下黏蛋白的复合和聚集

Vlad Dinu, Yudong Lu, Nicola Weston, Ryan Lithgo, Hayley Coupe, Guy Channell, Gary G Adams, Amelia Torcello Gómez, Carlos Sabater, Alan Mackie, Christopher Parmenter, Ian Fisk, Mary K Phillips-Jones, Stephen E Harding

Changes in Membrane Protein Structural Biology

膜蛋白结构生物学的变化

Birch, James; Cheruvara, Harish; Gamage, Nadisha; Harrison, Peter J; Lithgo, Ryan; Quigley, Andrew

Characterisation of insulin analogues therapeutically available to patients

对可用于治疗的胰岛素类似物进行表征

Adams, Gary G; Meal, Andrew; Morgan, Paul S; Alzahrani, Qushmua E; Zobel, Hanne; Lithgo, Ryan; Kok, M Samil; Besong, David T M; Jiwani, Shahwar I; Ballance, Simon; Harding, Stephen E; Chayen, Naomi; Gillis, Richard B