日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The Radical SAM Enzyme BlsE Can Operate as a Dehydratase, Dehydrogenase, or Epimerase upon Mutation of a Single Active Site Serine Residue

自由基SAM酶BlsE在单个活性位点丝氨酸残基发生突变后,可以作为脱水酶、脱氢酶或差向异构酶发挥作用。

Lee, Yu-Hsuan; Zheng, Ziyang; Ma, Baixu; Ren, Daan; Ruszczycky, Mark W; Tao, Lizhi; Liu, Hung-Wen

Radical S-adenosyl-l-methionine FeS cluster implicated as the sulfur donor during albomycin biosynthesis

自由基S-腺苷-L-蛋氨酸FeS簇被认为是白霉素生物合成过程中的硫供体。

Ushimaru, Richiro; Zheng, Ziyang; Xiong, Jin; Mori, Takahiro; Abe, Ikuro; Guo, Yisong; Liu, Hung-Wen

Reinvestigation of the C-Glycoside Synthase in Alnumycin Biosynthesis Reveals a Conserved Mechanism of C-C Bond Formation

对阿努霉素生物合成中C-糖苷合成酶的重新研究揭示了C-C键形成的保守机制

Ren, Daan; Lee, Yu-Hsuan; Liu, Hung-Wen

Revision of the Formycin A and Pyrazofurin Biosynthetic Pathways Reveals Specificity for d-Glutamic Acid and a Cryptic N-Acylation Step During Pyrazole Core Formation

对福霉素A和吡唑呋喃生物合成途径的修订揭示了对d-谷氨酸的特异性以及吡唑核心形成过程中一个隐蔽的N-酰化步骤

Zheng, Ziyang; Ren, Daan; Ko, Yeonjin; Liu, Hung-Wen

Radical Propagation via σ-Cleavage Mediates Radical SAM Catalyzed Sulfur-for-Oxygen Swapping Reaction during the Biosynthesis of Albomycin δ(2)

σ-裂解介导自由基传播,在白霉素δ(2)生物合成过程中催化自由基SAM催化的硫氧交换反应

Zheng, Ziyang; Ushimaru, Richiro; Thomas, Conor M; Liu, Hung-Wen

EPR Characterization of the BlsE Substrate Radical Offers Insight into the Determinants of Reaction Outcome that Distinguish Radical SAM Dioldehydratases from Dehydrogenases

通过EPR表征BlsE底物自由基,可以深入了解区分自由基SAM二醇脱水酶和脱氢酶的反应结果决定因素。

Ma, Baixu; Lee, Yu-Hsuan; Ruszczycky, Mark W; Ren, Daan; Engstrom, Amelia; Liu, Hung-Wen; Tao, Lizhi

Refining the Substrate-Cofactor Disposition Model of Hyoscyamine 6β-Hydroxylase Catalysis Using Hyoscyamine Analogs

利用莨菪碱类似物改进莨菪碱6β-羟化酶催化的底物-辅因子分布模型

Ushimaru, Richiro; Chen, Ridao; Fan, Po-Hsun; Liu, Xiao; Ruszczycky, Mark W; Liu, Hung-Wen

A Selenium-for-Oxygen Swapping Reaction Catalyzed by the Radical S-Adenosyl Methionine Enzyme AbmM

由自由基S-腺苷甲硫氨酸酶AbmM催化的硒氧交换反应

Zheng, Ziyang; Lee, Yu-Hsuan; Liu, Hung-Wen

Biosynthesis of the Thiofuranose Core in Albomycin Requires a Versatile Enzyme AbmG That Catalyzes Net Dehydration via Cryptic Phosphorylation

Albomycin 中硫代呋喃糖核心的生物合成需要一种多功能酶 AbmG,该酶通过隐蔽磷酸化催化净脱水反应。

Zheng, Ziyang; Ushimaru, Richiro; Mori, Takahiro; Ruszczycky, Mark W; Abe, Ikuro; Liu, Hung-Wen

A [2.1.0]-Fused Bicyclic Intermediate Is Produced during the Biosynthesis of Oxetane Nucleosides

[2.1.0] 在氧杂环丁烷核苷的生物合成过程中会产生稠合双环中间体

Lee, Yu-Hsuan; Fan, Po-Hsun; Yeh, Yu-Cheng; Ruszczycky, Mark W; Geng, Yujie; Zhong, Aoshu; Liu, Hung-Wen