PARG inhibition suppresses breast cancer progression and potentiates immunoresponse through MTDH degradation mediated by E3 ligase ITCH-dependent ubiquitination.
PARG 抑制通过 E3 连接酶 ITCH 依赖性泛素化介导的 MTDH 降解来抑制乳腺癌进展并增强免疫反应。
期刊:NPJ Breast Cancer
影响因子:7.6
doi:10.1038/s41523-025-00847-3
Wang Junnai, Dong Yanhua, Lun Weiwei, Nai Manman, Shi Yajing, Geng Jianfang, Cai Wenhui, Liu Jiaxi, Li Hongyu, Li Lei
肿瘤
表观遗传
肿瘤免疫
泛素化
乳腺癌
ITCH
PARG
免疫/内分泌