日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of first-in-class inhibitors of the TRF1:TIN2 protein:protein interaction by fragment screening.

通过片段筛选发现TRF1:TIN2蛋白相互作用的首创抑制剂。

Casale Giacomo, Liu Manjuan, Le Bihan Yann-Vaï, Inian Oviya, Stammers Ellie, Caldwell John, van Montfort Rob L M, Collins Ian, Guettler Sebastian

Determination of Ligand-Binding Affinity (K(d)) Using Transverse Relaxation Rate (R(2)) in the Ligand-Observed (1)H NMR Experiment and Applications to Fragment-Based Drug Discovery

利用配体观测的(1)H NMR实验中的横向弛豫速率(R(2))测定配体结合亲和力(K(d))及其在基于片段的药物发现中的应用

Liu, Manjuan; Mirza, Amin; McAndrew, P Craig; Thapaliya, Arjun; Pierrat, Olivier A; Stubbs, Mark; Hahner, Tamas; Chessum, Nicola E A; Innocenti, Paolo; Caldwell, John; Cheeseman, Matthew D; Bellenie, Benjamin R; van Montfort, Rob L M; Newton, Gary K; Burke, Rosemary; Collins, Ian; Hoelder, Swen

HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies

HSF1通路抑制剂临床候选药物(CCT361814/NXP800)基于表型筛选开发,有望用于治疗难治性卵巢癌和其他恶性肿瘤。

Pasqua, A Elisa; Sharp, Swee Y; Chessum, Nicola E A; Hayes, Angela; Pellegrino, Loredana; Tucker, Michael J; Miah, Asadh; Wilding, Birgit; Evans, Lindsay E; Rye, Carl S; Mok, N Yi; Liu, Manjuan; Henley, Alan T; Gowan, Sharon; De Billy, Emmanuel; Te Poele, Robert; Powers, Marissa; Eccles, Suzanne A; Clarke, Paul A; Raynaud, Florence I; Workman, Paul; Jones, Keith; Cheeseman, Matthew D

Fragment-based screening identifies molecules targeting the substrate-binding ankyrin repeat domains of tankyrase.

基于片段的筛选可识别靶向 tankyrase 底物结合锚蛋白重复结构域的分子

Pollock Katie, Liu Manjuan, Zaleska Mariola, Meniconi Mirco, Pfuhl Mark, Collins Ian, Guettler Sebastian

Evaluation of APOBEC3B Recognition Motifs by NMR Reveals Preferred Substrates

利用核磁共振技术评估APOBEC3B识别基序,揭示其优先底物

Liu, Manjuan; Mallinger, Aurélie; Tortorici, Marcello; Newbatt, Yvette; Richards, Meirion; Mirza, Amin; van Montfort, Rob L M; Burke, Rosemary; Blagg, Julian; Kaserer, Teresa

Synthesis and Evaluation of a 2,11-Cembranoid-Inspired Library

2,11-雪松烷类化合物启发化合物库的合成与评价

Welford, Amanda J; Caldwell, John J; Liu, Manjuan; Richards, Meirion; Brown, Nathan; Lomas, Cara; Tizzard, Graham J; Pitak, Mateusz B; Coles, Simon J; Eccles, Suzanne A; Raynaud, Florence I; Collins, Ian

Structure-based design of orally bioavailable 1H-pyrrolo[3,2-c]pyridine inhibitors of mitotic kinase monopolar spindle 1 (MPS1)

基于结构的口服生物利用度高的1H-吡咯并[3,2-c]吡啶类有丝分裂激酶单极纺锤体1 (MPS1) 抑制剂设计

Naud, Sébastien; Westwood, Isaac M; Faisal, Amir; Sheldrake, Peter; Bavetsias, Vassilios; Atrash, Butrus; Cheung, Kwai-Ming J; Liu, Manjuan; Hayes, Angela; Schmitt, Jessica; Wood, Amy; Choi, Vanessa; Boxall, Kathy; Mak, Grace; Gurden, Mark; Valenti, Melanie; de Haven Brandon, Alexis; Henley, Alan; Baker, Ross; McAndrew, Craig; Matijssen, Berry; Burke, Rosemary; Hoelder, Swen; Eccles, Suzanne A; Raynaud, Florence I; Linardopoulos, Spiros; van Montfort, Rob L M; Blagg, Julian