日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structure-Guided Engineering of a Cas12i Nuclease Unlocks Near-PAMless Genome Editing.

通过结构导向的 Cas12i 核酸酶工程改造,实现了近乎无 PAM 序列的基因组编辑。

Chen Qitong, Gou Hanlin, Xu Chao, Wang Sihan, Zhang Huitao, Song Minglei, Wang Mengge, Ji Xingkun, Wei Xiaofei, Tan Yuanyan, Quan Hehua, Luo Pengyu, Shou Hanyu, Liu Pengpeng, Liang Yafeng, Zhu Jian-Kang

Adissp activates insulin-independent glucose disposal and energy expenditure in white fat to treat diabetes and cardiometabolic disease

Adissp 可激活白色脂肪中不依赖胰岛素的葡萄糖利用和能量消耗,从而治疗糖尿病和心血管代谢疾病。

Huang, Lei; Liu, Pengpeng; Chen, Qingbo; Hu, Kai; Li, Shaoxian; Lee, Alexandra; Wabitsch, Martin; Zhu, Lihua Julie; Yu, Qing; Davis, Roger; Czech, Michael P; Wolfe, Scot A; Wang, Yong-Xu

LINE-1 retrotransposition modulates metabolic stress and promotes cuproptosis resistance in lung squamous cell carcinoma by disrupting mitochondrial membrane homeostasis

LINE-1逆转座通过破坏线粒体膜稳态来调节代谢应激并促进肺鳞状细胞癌的铜凋亡抵抗。

Zhang, Rui; Zhang, Xiao; Tian, Wenjing; Wang, Chenhui; Zhang, Lianmin; Wang, Hailong; Liu, Pengpeng; Chen, Guidong; Yi, Jiajia; Zhang, Weijia; Yu, Jinpu

Impact of rice wine-steamed Cistanche deserticola polysaccharides on intestinal flora and immunological modulation in immunosuppressive mice induced by cyclophosphamide

米酒蒸制肉苁蓉多糖对环磷酰胺诱导的免疫抑制小鼠肠道菌群及免疫调节的影响

Lian, Jing; Zhu, Yuexin; Hu, Qiushi; Dong, Kexu; Peng, Zihang; Feng, Yurou; Ling, Na; Yu, Caina; Liu, Pengpeng; Lei, Xuefei; Shi, Ji; Jia, Tianzhu

mRNA-engineered CRISPR-Cas epigenetic editors enable durable and efficient gene silencing in vivo.

mRNA工程化的CRISPR-Cas表观遗传编辑器可在体内实现持久高效的基因沉默。

Xu Chao, Zeng Chen, Wang Mengge, Wei Xiaofei, Song Minglei, Liu Xiaoyi, Wang Weiping, Chen Qitong, Ji Xingkun, Luo Pengyu, Ma Liyong, Sun Yan, Gou Hanlin, Zhu Zeyao, Li Xiaohua, Lv Yu-Xuan, Liu Pengpeng, Zhu Jian-Kang

Increasing intracellular dNTP levels improves prime editing efficiency.

提高细胞内dNTP水平可提高先导编辑效率

Liu Pengpeng, Ponnienselvan Karthikeyan, Nyalile Thomas, Oikemus Sarah, Joynt Anya T, Iyer Sukanya, Kelly Karen, Guo Dongsheng, Kyawe Pyae P, Vanderleeden Emma, Redick Sambra D, Huang Lei, Chen Zexiang, Lee Jeong Min, Schiffer Celia A, Harlan David M, Wang Jennifer P, Emerson Charles P Jr, Lawson Nathan D, Watts Jonathan K, Sontheimer Erik J, Luban Jeremy, Wolfe Scot A

In vivo prime editing rescues photoreceptor degeneration in nonsense mutant retinitis pigmentosa.

体内基因编辑可挽救无义突变视网膜色素变性中的感光细胞退化

Fu Yidian, He Xiaoyu, Ma Liang, Gao Xin D, Liu Pengpeng, Shi Hanhan, Chai Peiwei, Ge Shengfang, Jia Renbing, Liu David R, Fan Xianqun, Yang Zhi

Exome Sequencing Reveals the Genetic Architecture of Non-syndromic Orofacial Clefts and Identifies BOC as a Novel Causal Gene.

外显子组测序揭示了非综合征性口面裂的遗传结构,并将BOC鉴定为一个新的致病基因

He Qing, Yu Min, Jiao Yuhua, Xu Yizhu, Liang Xuqin, Huang Wenbin, Xu Linping, Hou Yuxia, Ren Zhanping, Lyu Beile, Qian Zhenwei, Liu Pengpeng, Zhou Jing, Huang Huimei, Yin Chunyan, Zhao Huaxiang, Ding Yi

Quasi-two-dimensional ferroelectricity with multiple switchable polarization states in N-H coinjected perovskite manganites

NH共注入钙钛矿锰酸盐中具有多个可切换极化态的准二维铁电性

Wei, Xian-Kui; Liu, Feng; Wang, Yi; Liang, Zhiyao; Liu, Pengpeng; Zhou, Ying; Cao, Lei; Cao, Pengfei; Li, Yi; Prucnal, Slawomir; Petracic, Oleg; Xiao, Yinguo; Lu, Penghan; Lazić, Ivan; Dong, Shuai; Zhou, Shengqiang; Dunin-Borkowski, Rafal E

Targeted inhibition of MDSC-derived exosomal miR-155-5p restrains epithelial-mesenchymal transition in hormone receptor-positive breast cancer by regulating SIRT1

靶向抑制MDSC来源的外泌体miR-155-5p可通过调节SIRT1抑制激素受体阳性乳腺癌的上皮-间质转化。

Chen, Guidong; Wang, Silei; Wang, Fanchen; Yang, Chenju; Zhang, Rui; Liu, Pengpeng; Ning, Junya; Wang, Shuyu; Ma, Feihe; Xu, Linlin; Shi, Linqi; Yu, Jinpu