日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of an ITK and TRK kinase inhibitor for the potential topical treatment of atopic dermatitis

发现一种ITK和TRK激酶抑制剂,可用于治疗特应性皮炎。

Duffen, Jennifer L; Crouse, Kimberly K; Ji, Lin; Brault, Amy L; Ford, Kristen; Brooks, Jonathan; Jelinsky, Scott A; Li, Yizheng; Shin, Julia H; Zhao, Yajuan; Andreyeva, Tatyana; Hammerman, Katherine; Arnold, Christina; Sheldon, Richard T; Garren, Jeonifer; LaBarge, Wes; Resek, Anthony; Volmer, Jon; Bagley, Scott W; Casimiro-Garcia, Agustin; Chinigo, Gary M; Davoren, Jennifer E; Denny, Rajiah Aldrin; Drozda, Susan; Foley, Timothy L; Hicklin, Robert W; Liu, Shenping; Lovering, Frank E; Nedoma, Nicole L; Parikh, Mihir D; Strohbach, Joseph W; Trujillo, John I; Steyn, Stefanus J; Nocka, Karl; Hegen, Martin; Vincent, Fabien; Lee, Katherine L; Gerstenberger, Brian S; Primiano, Michael J

Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants

合成17B-HSD13底物的设计和应用揭示了保护性人类变体的催化活性得以保留

Garnsey, Michelle R; Wang, Yang; Edmonds, David J; Sammons, Matthew F; Reidich, Benjamin; Ahn, Youngwook; Ashkenazi, Yotam; Carlo, Anthony; Cerny, Matthew A; Coffman, Karen J; Culver, Jeffrey A; Dechert Schmitt, Anne-Marie; Eng, Heather; Fisher, Ethan L; Gutierrez, Jemy A; James, Larry; Jordan, Samantha; Kohrt, Jeffrey T; Kramer, Melissa; LaChapelle, Erik A; Lee, Jack C; Lee, Jisun; Li, Dongmei; Li, Zhenhong; Liu, Shenping; Liu, Jianhua; Magee, Thomas V; Miller, Melissa R; Moran, Michael; Nason, Deane M; Nedoma, Nicole L; O'Neil, Steven V; Piotrowski, Mary A; Racich, Jillian; Sommese, Ruth F; Stevens, Lucy M; Wright, Ann S; Xiao, Jun; Zhang, Liying; Zhou, Dahui; Barrandon, Ornella; Clasquin, Michelle F

Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca(2+) dependent allosteric binding site.

通过靶向 Ca(2+) 依赖性变构结合位点来抑制肽基精氨酸脱亚胺酶 (PAD1-4)

Dakin Leslie A, Xing Li, Hall Justin, Ding Weidong, Vajdos Felix F, Pelker Jeffrey W, Ramsey Simeon, Balbo Paul, Sahasrabudhe Parag V, Banker Mary Ellen, Choi Won Young, Wright Stephen W, Chang Jeanne S, Curto John M, Davoren Jennifer E, Drozda Susan E, Fennell Kimberly F, Futatsugi Kentaro, Kortum Steve, Lee Katherine L, Liu Shenping, Lovering Frank, Nicki Jennifer A, Trujillo John I, Vincent Fabien, Schnute Mark E

Cyclosporine A sterically inhibits statin transport by solute carrier OATP1B1

环孢素A通过空间位阻抑制溶质载体OATP1B1转运他汀类药物。

Sung, Min Woo; Hu, Kuan; Hurlimann, Lea M; Lees, Joshua A; Fennell, Kimberly F; West, Mark A; Costales, Chester; Rodrigues, Amilcar David; Zimmermann, Iwan; Dawson, Roger J P; Liu, Shenping; Han, Seungil

The role of the SOX2 gene in cervical cancer: focus on ferroptosis and construction of a predictive model

SOX2基因在宫颈癌中的作用:聚焦铁死亡及预测模型的构建

Liu, Shenping; Wei, Zhi; Ding, Huiqing

Correction: The role of the SOX2 gene in cervical cancer: focus on ferroptosis and construction of a predictive model

更正:SOX2基因在宫颈癌中的作用:聚焦铁死亡及预测模型的构建

Liu, Shenping; Wei, Zhi; Ding, Huiqing

Primary ovarian insufficiency consequence of autoimmune diseases: a bidirectional two-sample Mendelian randomization study

自身免疫性疾病导致的原发性卵巢功能不全:一项双向双样本孟德尔随机化研究

Du, Yongming; Hu, Yichao; Sheng, Yuehua; Zhu, Tianhong; Liu, Shenping; Ding, Huiqing; Guan, Yutao

Biophysical and mechanistic insights into novel allosteric inhibitor of spleen tyrosine kinase

脾酪氨酸激酶新型变构抑制剂的生物物理学和机制研究

Hall, Justin; Aulabaugh, Ann; Rajamohan, Francis; Liu, Shenping; Kaila, Neelu; Wan, Zhao-Kui; Ryan, Mark; Magyar, Rachelle; Qiu, Xiayang

Crystal structures of cholesteryl ester transfer protein in complex with inhibitors

胆固醇酯转移蛋白与抑制剂复合物的晶体结构

Liu, Shenping; Mistry, Anil; Reynolds, Jennifer M; Lloyd, David B; Griffor, Matthew C; Perry, David A; Ruggeri, Roger B; Clark, Ronald W; Qiu, Xiayang

Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations

深入了解葡萄糖激酶激活机制:观察到多种不同的蛋白质构象

Liu, Shenping; Ammirati, Mark J; Song, Xi; Knafels, John D; Zhang, Jeff; Greasley, Samantha E; Pfefferkorn, Jeffrey A; Qiu, Xiayang