日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A phenotypic screen for novel small molecules that correct tau-mediated pathologies in human frontotemporal dementia neurons.

对能够纠正人类额颞叶痴呆神经元中 tau 蛋白介导的病理的新型小分子进行表型筛选

Maxwell Hannah, Smith James, Campbell Tom, Clark Jason, La Rocca Rosanna, Paonessa Francesco, Sitnikov Sergey, Evans Mark, Maycox Peter, Livesey Frederick J

Synaptotoxic effects of extracellular tau are mediated by its microtubule-binding region.

细胞外 tau 蛋白的突触毒性作用是由其微管结合区介导的

Ondrejcak Tomas, Hu Neng-Wei, Coode Emily, Campbell Tom, Corbett Grant T, Doykov Ivan, Mills Kevin, Walsh Dominic M, Livesey Frederick J, Rowan Michael J, Klyubin Igor

Tau uptake by human neurons depends on receptor LRP1 and kinase LRRK2.

人类神经元对 Tau 蛋白的摄取依赖于受体 LRP1 和激酶 LRRK2

Evans Lewis D, Strano Alessio, Tuck Eleanor, Campbell Ashley, Smith James, Hung Christy, Behr Tiana S, Ghetti Bernardino, Ryskeldi-Falcon Benjamin, Karakoc Emre, Iorio Francesco, Reith Alastair, Bassett Andrew R, Livesey Frederick J

The role of contactin-associated protein-like 2 in neurodevelopmental disease and human cerebral cortex evolution

接触蛋白相关蛋白样2在神经发育疾病和人类大脑皮层进化中的作用

St George-Hyslop, Frances; Kivisild, Toomas; Livesey, Frederick J

Endolysosome and autophagy dysfunction in Alzheimer disease

阿尔茨海默病中的内溶酶体和自噬功能障碍

Hung, Christy; Livesey, Frederick J

Mutations in thyroid hormone receptor α1 cause premature neurogenesis and progenitor cell depletion in human cortical development

甲状腺激素受体α1的突变会导致人类皮层发育过程中神经发生过早和祖细胞耗竭

Krieger, Teresa G; Moran, Carla M; Frangini, Alberto; Visser, W Edward; Schoenmakers, Erik; Muntoni, Francesco; Clark, Chris A; Gadian, David; Chong, Wui K; Kuczynski, Adam; Dattani, Mehul; Lyons, Greta; Efthymiadou, Alexandra; Varga-Khadem, Faraneh; Simons, Benjamin D; Chatterjee, Krishna; Livesey, Frederick J

In vivo modeling of human neuron dynamics and Down syndrome

人体神经元动力学和唐氏综合征的体内建模

Real, Raquel; Peter, Manuel; Trabalza, Antonio; Khan, Shabana; Smith, Mark A; Dopp, Joana; Barnes, Samuel J; Momoh, Ayiba; Strano, Alessio; Volpi, Emanuela; Knott, Graham; Livesey, Frederick J; De Paola, Vincenzo

Chromatin Accessibility Impacts Transcriptional Reprogramming in Oocytes

染色质可及性影响卵母细胞的转录重编程

Miyamoto, Kei; Nguyen, Khoi T; Allen, George E; Jullien, Jerome; Kumar, Dinesh; Otani, Tomoki; Bradshaw, Charles R; Livesey, Frederick J; Kellis, Manolis; Gurdon, John B

Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity

来自阿尔茨海默病iPSC模型的细胞外Aβ和Tau蛋白会破坏突触可塑性

Hu, Neng-Wei; Corbett, Grant T; Moore, Steven; Klyubin, Igor; O'Malley, Tiernan T; Walsh, Dominic M; Livesey, Frederick J; Rowan, Michael J

Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia

人类干细胞衍生小胶质细胞中错义TREM2突变的功能研究

Brownjohn, Philip W; Smith, James; Solanki, Ravi; Lohmann, Ebba; Houlden, Henry; Hardy, John; Dietmann, Sabine; Livesey, Frederick J