日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

EGFR-mutant transformed small cell lung cancer harbors intratumoral heterogeneity targetable with MEK inhibitor combination therapy.

EGFR突变型小细胞肺癌具有肿瘤内异质性,可通过MEK抑制剂联合疗法进行靶向治疗。

Ogino Atsuko, Vajdi Amir, Mu Xinmeng Jasmine, Mahadevan Navin R, Ngo Kenneth, Booker Matthew A, Cejas Paloma, Okoro Jeffrey J, Xu Man, Springer Benjamin F, Eschle Benjamin K, Messier Cameron M, Wang Stephen, Syamala Sudeepa, Tamen Rubii M, Adeni Anika E, Chambers Emily S, Canadas Israel, Thai Tran, Christensen Camilla L, Xu Chunxiao, Lizotte Patrick H, Oxnard Geoffrey R, Watanabe Hideo, Long Henry W, Gokhale Prafulla C, Paweletz Cloud P, Sholl Lynette M, Oser Matthew G, Barbie David A, Tolstorukov Michael Y, Jänne Pasi A

Phase I Clinical Trial of the Bifunctional EGFR/TGF-β Fusion Protein Ficerafusp Alfa (BCA101) Alone and in Combination with Pembrolizumab for Advanced Solid Tumors

双功能 EGFR/TGF-β 融合蛋白 Ficerafusp Alfa (BCA101) 单药及联合帕博利珠单抗治疗晚期实体瘤的 I 期临床试验

Hernando-Calvo, Alberto; Carvajal, Richard D; Paik, Paul K; Morris, Van Karlyle; Zandberg, Dan P; Kaczmar, John M; Bohr, David N; Reiners, Ralf D; Gharakhani, Elham; Salazar, Rachel L; Lizotte, Patrick Hall; Ivanova, Elena V; Bedard, Philippe L; Hanna, Glenn J

Cancers modulate p53 truncal neoantigen display to evade T cell detection

癌细胞通过调控p53主干新抗原的表达来逃避T细胞的检测。

Haratani, Koji; Reinhold, Bruce; Duke-Cohan, Jonathan S; Fahey, Caroline G; Tan, Kemin; Mallis, Robert J; Gusev, Alexander; Kehl, Kenneth L; Luo, Jia; Holliday, Elizabeth L; Masi, Daniel J; Karmazyn, Allyson; Zienkiewicz, Katarzyna J; Hennessey, Connor J; Blasco, Rafael B; Thai, Tran C; Gibbons, Grace M; Kivlehan, Sophie; Lizotte, Patrick; Paweletz, Cloud P; Aguirre, Andrew J; Ligon, Keith L; Chiarle, Roberto; Lang, Matthew J; Barbie, David A; Reinherz, Ellis L

Atomistic TCR-ligand interactions instruct memory T-cell differentiation

原子级TCR-配体相互作用指导记忆性T细胞分化

Akitsu, Aoi; Tan, Kemin; Mallis, Robert J; Booker, Matthew A; Duke-Cohan, Jonathan S; Brazin, Kristine N; Kirkpatrick, Evan H; Parkins, Andrew N; Aryal, Sarita; Cinella, Vincenzo; Lee, Jonathan J; Uberoy, Kaveri I; Koenig, Jenna K; Biddle, Matthew; Messier, Cameron M; Lizotte, Patrick H; Tolstorukov, Michael Y; Hwang, Wonmuk; Lang, Matthew J; Reinherz, Ellis L

Nivolumab for Patients With High-Risk Oral Leukoplakia: A Nonrandomized Controlled Trial

纳武利尤单抗治疗高危口腔白斑患者:一项非随机对照试验

Hanna, Glenn J; Villa, Alessandro; Nandi, Shuvro P; Shi, Ruichao; ONeill, Anne; Liu, Mofei; Quinn, Charles T; Treister, Nathaniel S; Sroussi, Herve Y; Vacharotayangul, Piamkamon; Goguen, Laura A; Annino, Donald J Jr; Rettig, Eleni M; Jo, Vickie Y; Wong, Kristine S; Lizotte, Patrick; Paweletz, Cloud P; Uppaluri, Ravindra; Haddad, Robert I; Cohen, Ezra E W; Alexandrov, Ludmil B; William, William N Jr; Lippman, Scott M; Woo, Sook-Bin

Neoadjuvant and Adjuvant Nivolumab and Lirilumab in Patients with Recurrent, Resectable Squamous Cell Carcinoma of the Head and Neck

纳武利尤单抗和利利尤单抗用于复发性、可切除的头颈部鳞状细胞癌患者的新辅助和辅助治疗

Hanna, Glenn J; O'Neill, Anne; Shin, Kee-Young; Wong, Kristine; Jo, Vickie Y; Quinn, Charles T; Cutler, Jennifer M; Flynn, Michelle; Lizotte, Patrick H; Annino, Donald J Jr; Goguen, Laura A; Kass, Jason I; Rettig, Eleni M; Sethi, Rosh K V; Lorch, Jochen H; Schoenfeld, Jonathan D; Margalit, Danielle N; Tishler, Roy B; Everett, Peter C; Desai, Anupam M; Cavanaugh, Megan E; Paweletz, Cloud P; Egloff, Ann Marie; Uppaluri, Ravindra; Haddad, Robert I

Corrigendum: Selective Histone Deacetylase Inhibitor ACY-241 (Citarinostat) Plus Nivolumab in Advanced Non-Small Cell Lung Cancer: Results From a Phase Ib Study

更正:选择性组蛋白去乙酰化酶抑制剂 ACY-241(西他诺司他)联合纳武利尤单抗治疗晚期非小细胞肺癌:一项 Ib 期研究的结果

Awad, Mark M; Le Bruchec, Yvan; Lu, Brian; Ye, Jason; Miller, Julie Ann; Lizotte, Patrick H; Cavanaugh, Megan E; Rode, Amanda J; Dumitru, Calin Dan; Spira, Alexander

Phase II study of pembrolizumab in refractory esophageal cancer with correlates of response and survival

帕博利珠单抗治疗难治性食管癌的II期研究及其疗效和生存率相关因素

de Klerk, Leonie K; Patel, Anuj K; Derks, Sarah; Pectasides, Eirini; Augustin, Jeremy; Uduman, Mohamed; Raman, Nihal; Akarca, Fahire G; McCleary, Nadine J; Cleary, James M; Rubinson, Douglas A; Clark, Jeffrey W; Fitzpatrick, Bridget; Brais, Lauren K; Cavanaugh, Megan E; Rode, Amanda J; Jean, Melissa G; Lizotte, Patrick H; Nazzaro, Matthew J; Severgnini, Mariano; Zheng, Hui; Fuchs, Charles S; Enzinger, Peter C; Bass, Adam J

Frameshift events predict anti-PD-1/L1 response in head and neck cancer.

移码事件可预测头颈癌中抗PD-1/L1的疗效

Hanna Glenn J, Lizotte Patrick, Cavanaugh Megan, Kuo Frank C, Shivdasani Priyanka, Frieden Alexander, Chau Nicole G, Schoenfeld Jonathan D, Lorch Jochen H, Uppaluri Ravindra, MacConaill Laura E, Haddad Robert I

Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies

在216个癌细胞系中进行平行全基因组规模的功能缺失筛选,以识别特定背景下的遗传依赖性

Cowley, Glenn S; Weir, Barbara A; Vazquez, Francisca; Tamayo, Pablo; Scott, Justine A; Rusin, Scott; East-Seletsky, Alexandra; Ali, Levi D; Gerath, William Fj; Pantel, Sarah E; Lizotte, Patrick H; Jiang, Guozhi; Hsiao, Jessica; Tsherniak, Aviad; Dwinell, Elizabeth; Aoyama, Simon; Okamoto, Michael; Harrington, William; Gelfand, Ellen; Green, Thomas M; Tomko, Mark J; Gopal, Shuba; Wong, Terence C; Li, Hubo; Howell, Sara; Stransky, Nicolas; Liefeld, Ted; Jang, Dongkeun; Bistline, Jonathan; Hill Meyers, Barbara; Armstrong, Scott A; Anderson, Ken C; Stegmaier, Kimberly; Reich, Michael; Pellman, David; Boehm, Jesse S; Mesirov, Jill P; Golub, Todd R; Root, David E; Hahn, William C