日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Genetic and Phenotypic Changes Related to the Development of mec-Independent Oxacillin Non-Susceptibility in ST8 Staphylococcus aureus Recovered after Antibiotic Therapy in a Patient with Bacteremia

在一名菌血症患者接受抗生素治疗后康复的ST8金黄色葡萄球菌中,与mec非依赖性苯唑西林耐药性发展相关的遗传和表型变化

Di Gregorio, Sabrina; Weltman, Gabriela; Fabbri, Carolina; Fernández, Silvina; Zárate, Soledad; Smayevsky, Jorgelina; Power, Pablo; Campos, Josefina; Llarrull, Leticia Irene; Mollerach, Marta

An experiment-informed signal transduction model for the role of the Staphylococcus aureus MecR1 protein in β-lactam resistance

金黄色葡萄球菌 MecR1 蛋白在 β-内酰胺耐药中的作用的实验信息信号转导模型

Bruno S Belluzo, Luciano A Abriata, Estefanía Giannini, Damila Mihovilcevic, Matteo Dal Peraro, Leticia I Llarrull

The Reaction Mechanism of Metallo-β-Lactamases Is Tuned by the Conformation of an Active-Site Mobile Loop

金属-β-内酰胺酶的反应机制由活性位点移动环的构象调节

Antonela R Palacios #, María F Mojica #, Estefanía Giannini, Magdalena A Taracila, Christopher R Bethel, Pedro M Alzari, Lisandro H Otero, Sebastián Klinke, Leticia I Llarrull, Robert A Bonomo, Alejandro J Vila2

A general reaction mechanism for carbapenem hydrolysis by mononuclear and binuclear metallo-β-lactamases

单核和双核金属β-内酰胺酶水解碳青霉烯类抗生素的一般反应机理

Lisa, María-Natalia; Palacios, Antonela R; Aitha, Mahesh; González, Mariano M; Moreno, Diego M; Crowder, Michael W; Bonomo, Robert A; Spencer, James; Tierney, David L; Llarrull, Leticia I; Vila, Alejandro J

Overcoming differences: The catalytic mechanism of metallo-β-lactamases

克服差异:金属β-内酰胺酶的催化机制

Meini, María-Rocío; Llarrull, Leticia I; Vila, Alejandro J

Lysine Nzeta-decarboxylation switch and activation of the beta-lactam sensor domain of BlaR1 protein of methicillin-resistant Staphylococcus aureus

耐甲氧西林金黄色葡萄球菌BlaR1蛋白的赖氨酸Nζ脱羧开关和β-内酰胺传感器结构域的激活

Borbulevych, Oleg; Kumarasiri, Malika; Wilson, Brian; Llarrull, Leticia I; Lee, Mijoon; Hesek, Dusan; Shi, Qicun; Peng, Jeffrey; Baker, Brian M; Mobashery, Shahriar

High-resolution crystal structure of MltE, an outer membrane-anchored endolytic peptidoglycan lytic transglycosylase from Escherichia coli

大肠杆菌外膜锚定内溶肽聚糖裂解转糖基酶MltE的高分辨率晶体结构

Artola-Recolons, Cecilia; Carrasco-López, César; Llarrull, Leticia I; Kumarasiri, Malika; Lastochkin, Elena; Martínez de Ilarduya, Iñaki; Meindl, Kathrin; Usón, Isabel; Mobashery, Shahriar; Hermoso, Juan A

Crystallization and preliminary X-ray diffraction analysis of the lytic transglycosylase MltE from Escherichia coli

大肠杆菌溶菌转糖基酶MltE的结晶和初步X射线衍射分析

Artola-Recolons, Cecilia; Llarrull, Leticia I; Lastochkin, Elena; Mobashery, Shahriar; Hermoso, Juan A

Exploring the functional space of thiiranes as gelatinase inhibitors using click chemistry

利用点击化学探索硫杂环丙烷作为明胶酶抑制剂的功能空间

Testero, Sebastian A; Llarrull, Leticia I; Fisher, Jed F; Chang, Mayland; Mobashery, Shahriar

The future of the β-lactams

β-内酰胺类抗生素的未来

Llarrull, Leticia I; Testero, Sebastian A; Fisher, Jed F; Mobashery, Shahriar