日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Fluorinated HIV-1 protease inhibitors containing chiral hydroxyethylbenzene and indanol as P2' ligands with potent activity against drug-resistant variants

含有手性羟乙基苯和茚满醇作为P2'配体的氟化HIV-1蛋白酶抑制剂，对耐药变体具有强效活性

期刊:European Journal of Medicinal Chemistry
影响因子:5.9
doi:10.1016/j.ejmech.2025.118510
Kaur, Jagroop; Spielvogel, Ean; Nageswara Rao, Desaboini; Rusere, Linah N; Shaqra, Ala M; Lockbaum, Gordon J; Maryam, Arooma; Yilmaz, Nese Kurt; Swanstrom, Ronald; Schiffer, Celia A; Ali, Akbar
HIV
微生物学
发表日期：2026
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Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9

ATX968 的发现：一种口服有效的 DHX9 变构抑制剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c00252
Daniels, Matthew H; Castro, Jennifer; Lee, Young-Tae; Gotur, Deepali; Knockenhauer, Kevin E; Grigoriu, Simina; Lockbaum, Gordon J; Cheong, Jae Eun; Lu, Chuang; Brennan, David; Buker, Shane M; Liu, Julie; Yao, Shihua; Sparling, Brian A; Sickmier, E Allen; Ribich, Scott; Blakemore, Steve J; Silver, Serena J; Boriack-Sjodin, P Ann; Duncan, Kenneth W; Copeland, Robert A
DHX9
发表日期：2025
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Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor.

核糖核酸外切酶 XRN1 作为癌症靶点的特性分析以及腺苷-3',5'-二磷酸作为强效酶抑制剂的鉴定

期刊:Communications Biology
影响因子:5.1
doi:10.1038/s42003-025-08005-y
Lockbaum Gordon J, Lynes Maureen M, Shen Sophie A, Liu Julie, Holt Nicholas, Nayak Sunaina P, Knockenhauer Kevin E, Yao Shihua, Sickmier E Allen, Raman Anugraha, Wu Jie, Case April, Shehaj Livia, Buker Shane M, Grigoriu Simina, Ribich Scott, Blakemore Stephen J, Sparling Brian A, Duncan Kenneth W, Copeland Robert A, Silver Serena J, Boriack-Sjodin P Ann
肿瘤
肿瘤免疫
发表日期：2025
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Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement

发现驱动蛋白KIF18A抑制剂ATX020：硅原子取代的战术应用

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.5c00512
Sparling, Brian A; Lee, Hyelee; Zablocki, Mary-Margaret; Lynes, Maureen M; Grigoriu, Simina; Shehaj, Livia; Lockbaum, Gordon J; Khan, Sanjoy K; Hotz, Taylor; Lee, Young-Tae; Buker, Shane M; Gotur, Deepali; Lu, Chuang; Ribich, Scott; Blakemore, Stephen J; Boriack-Sjodin, P Ann; Silver, Serena J; Copeland, Robert A; Duncan, Kenneth W
发表日期：2025
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Selection of HIV-1 for resistance to fifth-generation protease inhibitors reveals two independent pathways to high-level resistance

HIV-1 对第五代蛋白酶抑制剂产生耐药性的选择揭示了两种独立的高水平耐药途径

期刊:Elife
影响因子:6.4
doi:10.7554/eLife.80328
Ean Spielvogel, Sook-Kyung Lee, Shuntai Zhou, Gordon J Lockbaum, Mina Henes, Amy Sondgeroth, Klajdi Kosovrasti, Ellen A Nalivaika, Akbar Ali, Nese Kurt Yilmaz, Celia A Schiffer, Ronald Swanstrom
免疫
艾滋病
发表日期：2023
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HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues

具有 P1 膦酸酯修饰的 HIV-1 蛋白酶抑制剂通过增加与活瓣残基的相互作用来保持对抗耐药变体的效力

期刊:European Journal of Medicinal Chemistry
影响因子:6
doi:10.1016/j.ejmech.2023.115501
Gordon J Lockbaum, Linah N Rusere, Mina Henes, Klajdi Kosovrasti, Desaboini Nageswara Rao, Ean Spielvogel, Sook-Kyung Lee, Ellen A Nalivaika, Ronald Swanstrom, Nese Kurt Yilmaz, Celia A Schiffer, Akbar Ali
免疫
艾滋病
发表日期：2023
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Dual Inhibitors of Main Protease (M(Pro)) and Cathepsin L as Potent Antivirals against SARS-CoV2

主蛋白酶 (M(Pro)) 和组织蛋白酶 L 的双重抑制剂作为对抗 SARS-CoV-2 的有效抗病毒药物

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.2c04626
Mondal, Santanu; Chen, Yongzhi; Lockbaum, Gordon J; Sen, Sudeshna; Chaudhuri, Sauradip; Reyes, Archie C; Lee, Jeong Min; Kaur, Arshia N; Sultana, Nadia; Cameron, Michael D; Shaffer, Scott A; Schiffer, Celia A; Fitzgerald, Katherine A; Thompson, Paul R
微生物学
SARS-CoV-2
发表日期：2022
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Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond

避免直接抗病毒药物及其他药物产生耐药性的药物设计策略

期刊:Chemical Reviews
影响因子:55.8
doi:10.1021/acs.chemrev.0c00648
Matthew, Ashley N; Leidner, Florian; Lockbaum, Gordon J; Henes, Mina; Zephyr, Jacqueto; Hou, Shurong; Rao, Desaboini Nageswara; Timm, Jennifer; Rusere, Linah N; Ragland, Debra A; Paulsen, Janet L; Prachanronarong, Kristina; Soumana, Djade I; Nalivaika, Ellen A; Kurt Yilmaz, Nese; Ali, Akbar; Schiffer, Celia A
微生物学
发表日期：2021
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Unique structural solution from a V(H)3-30 antibody targeting the hemagglutinin stem of influenza A viruses

针对甲型流感病毒血凝素茎的V(H)3-30抗体的独特结构解析

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-020-20879-6
Harshbarger, Wayne D; Deming, Derrick; Lockbaum, Gordon J; Attatippaholkun, Nattapol; Kamkaew, Maliwan; Hou, Shurong; Somasundaran, Mohan; Wang, Jennifer P; Finberg, Robert W; Zhu, Quan Karen; Schiffer, Celia A; Marasco, Wayne A
微生物学
流感
发表日期：2021
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Inhibiting HTLV-1 Protease: A Viable Antiviral Target

抑制 HTLV-1 蛋白酶：可行的抗病毒靶点

期刊:ACS Chemical Biology
影响因子:3.5
doi:10.1021/acschembio.0c00975
Gordon J Lockbaum, Mina Henes, Nathaniel Talledge, Linah N Rusere, Klajdi Kosovrasti, Ellen A Nalivaika, Mohan Somasundaran, Akbar Ali, Louis M Mansky, Nese Kurt Yilmaz, Celia A Schiffer
微生物学
FCM
IF
IHC-P
WB
发表日期：2021
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