日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Fluorinated HIV-1 protease inhibitors containing chiral hydroxyethylbenzene and indanol as P2' ligands with potent activity against drug-resistant variants

含有手性羟乙基苯和茚满醇作为P2'配体的氟化HIV-1蛋白酶抑制剂，对耐药变体具有强效活性

期刊:European Journal of Medicinal Chemistry
影响因子:5.9
doi:10.1016/j.ejmech.2025.118510
Kaur, Jagroop; Spielvogel, Ean; Nageswara Rao, Desaboini; Rusere, Linah N; Shaqra, Ala M; Lockbaum, Gordon J; Maryam, Arooma; Yilmaz, Nese Kurt; Swanstrom, Ronald; Schiffer, Celia A; Ali, Akbar
HIV
微生物学
发表日期：2026
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Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9

ATX968 的发现：一种口服有效的 DHX9 变构抑制剂

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c00252
Daniels, Matthew H; Castro, Jennifer; Lee, Young-Tae; Gotur, Deepali; Knockenhauer, Kevin E; Grigoriu, Simina; Lockbaum, Gordon J; Cheong, Jae Eun; Lu, Chuang; Brennan, David; Buker, Shane M; Liu, Julie; Yao, Shihua; Sparling, Brian A; Sickmier, E Allen; Ribich, Scott; Blakemore, Steve J; Silver, Serena J; Boriack-Sjodin, P Ann; Duncan, Kenneth W; Copeland, Robert A
DHX9
发表日期：2025
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Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor.

核糖核酸外切酶 XRN1 作为癌症靶点的特性分析以及腺苷-3',5'-二磷酸作为强效酶抑制剂的鉴定

期刊:Communications Biology
影响因子:5.1
doi:10.1038/s42003-025-08005-y
Lockbaum Gordon J, Lynes Maureen M, Shen Sophie A, Liu Julie, Holt Nicholas, Nayak Sunaina P, Knockenhauer Kevin E, Yao Shihua, Sickmier E Allen, Raman Anugraha, Wu Jie, Case April, Shehaj Livia, Buker Shane M, Grigoriu Simina, Ribich Scott, Blakemore Stephen J, Sparling Brian A, Duncan Kenneth W, Copeland Robert A, Silver Serena J, Boriack-Sjodin P Ann
肿瘤
肿瘤免疫
发表日期：2025
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Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement

发现驱动蛋白KIF18A抑制剂ATX020：硅原子取代的战术应用

期刊:ACS Medicinal Chemistry Letters
影响因子:4
doi:10.1021/acsmedchemlett.5c00512
Sparling, Brian A; Lee, Hyelee; Zablocki, Mary-Margaret; Lynes, Maureen M; Grigoriu, Simina; Shehaj, Livia; Lockbaum, Gordon J; Khan, Sanjoy K; Hotz, Taylor; Lee, Young-Tae; Buker, Shane M; Gotur, Deepali; Lu, Chuang; Ribich, Scott; Blakemore, Stephen J; Boriack-Sjodin, P Ann; Silver, Serena J; Copeland, Robert A; Duncan, Kenneth W
发表日期：2025
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Dual Inhibitors of Main Protease (M(Pro)) and Cathepsin L as Potent Antivirals against SARS-CoV2

主蛋白酶 (M(Pro)) 和组织蛋白酶 L 的双重抑制剂作为对抗 SARS-CoV-2 的有效抗病毒药物

期刊:Journal of the American Chemical Society
影响因子:15.6
doi:10.1021/jacs.2c04626
Mondal, Santanu; Chen, Yongzhi; Lockbaum, Gordon J; Sen, Sudeshna; Chaudhuri, Sauradip; Reyes, Archie C; Lee, Jeong Min; Kaur, Arshia N; Sultana, Nadia; Cameron, Michael D; Shaffer, Scott A; Schiffer, Celia A; Fitzgerald, Katherine A; Thompson, Paul R
微生物学
SARS-CoV-2
发表日期：2022
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Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond

避免直接抗病毒药物及其他药物产生耐药性的药物设计策略

期刊:Chemical Reviews
影响因子:55.8
doi:10.1021/acs.chemrev.0c00648
Matthew, Ashley N; Leidner, Florian; Lockbaum, Gordon J; Henes, Mina; Zephyr, Jacqueto; Hou, Shurong; Rao, Desaboini Nageswara; Timm, Jennifer; Rusere, Linah N; Ragland, Debra A; Paulsen, Janet L; Prachanronarong, Kristina; Soumana, Djade I; Nalivaika, Ellen A; Kurt Yilmaz, Nese; Ali, Akbar; Schiffer, Celia A
微生物学
发表日期：2021
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Unique structural solution from a V(H)3-30 antibody targeting the hemagglutinin stem of influenza A viruses

针对甲型流感病毒血凝素茎的V(H)3-30抗体的独特结构解析

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-020-20879-6
Harshbarger, Wayne D; Deming, Derrick; Lockbaum, Gordon J; Attatippaholkun, Nattapol; Kamkaew, Maliwan; Hou, Shurong; Somasundaran, Mohan; Wang, Jennifer P; Finberg, Robert W; Zhu, Quan Karen; Schiffer, Celia A; Marasco, Wayne A
微生物学
流感
发表日期：2021
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Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode

泛3C蛋白酶抑制剂鲁平替韦以独特的结合模式与SARS-CoV-2主蛋白酶结合

期刊:Biochemistry
影响因子:3
doi:10.1021/acs.biochem.1c00414
Lockbaum, Gordon J; Henes, Mina; Lee, Jeong Min; Timm, Jennifer; Nalivaika, Ellen A; Thompson, Paul R; Kurt Yilmaz, Nese; Schiffer, Celia A
SARS-CoV-2
发表日期：2021
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Optimizing the refinement of merohedrally twinned P6(1) HIV-1 protease-inhibitor cocrystal structures

优化半面体孪晶P6(1) HIV-1蛋白酶抑制剂共晶体结构的精修

期刊:Acta Crystallographica Section D-Structural Biology
影响因子:3.8
doi:10.1107/S2059798320001989
Lockbaum, Gordon J; Leidner, Florian; Royer, William E; Kurt Yilmaz, Nese; Schiffer, Celia A
HIV
微生物学
发表日期：2020
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