日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Single-cell transcriptomic and genomic changes in the ageing human brain

衰老人脑中单细胞转录组和基因组的变化

Jeffries, Ailsa M; Yu, Tianxiong; Ziegenfuss, Jennifer S; Tolles, Allie K; Baer, Christina E; Sotelo, Cesar Bautista; Kim, Yerin; Weng, Zhiping; Lodato, Michael A

Prevalence and mechanisms of somatic deletions in single human neurons during normal aging and in DNA repair disorders

正常衰老和DNA修复障碍中单个人类神经元体细胞缺失的发生率和机制

Kim, Junho; Huang, August Yue; Johnson, Shelby L; Lai, Jenny; Isacco, Laura; Jeffries, Ailsa M; Miller, Michael B; Lodato, Michael A; Walsh, Christopher A; Lee, Eunjung Alice

Persistent DNA damage associated with ATM kinase deficiency promotes microglial dysfunction.

ATM激酶缺乏引起的持续性DNA损伤会促进小胶质细胞功能障碍

Bourseguin Julie, Cheng Wen, Talbot Emily, Hardy Liana, Lai Jenny, Jeffries Ailsa M, Lodato Michael A, Lee Eunjung Alice, Khoronenkova Svetlana V

The two faces of DNA oxidation in genomic and functional mosaicism during aging in human neurons

人类神经元衰老过程中基因组和功能嵌合现象中DNA氧化的双重作用

Lodato, Michael A; Ziegenfuss, Jennifer S

Editorial: Somatic mutations, genome mosaicism and aging

社论:体细胞突变、基因组嵌合与衰老

Lodato, Michael A; Vijg, Jan

Corrigendum: Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms

更正:基因组衰老:大脑中的体细胞突变将年龄相关性衰退与疾病联系起来,并揭示了致病机制

Lodato, Michael A; Walsh, Christopher A

Genome aging: somatic mutation in the brain links age-related decline with disease and nominates pathogenic mechanisms

基因组衰老:大脑中的体细胞突变将年龄相关性衰退与疾病联系起来,并揭示了致病机制

Lodato, Michael A; Walsh, Christopher A

Aging and neurodegeneration are associated with increased mutations in single human neurons

衰老和神经退行性疾病与单个人类神经元突变的增加有关。

Lodato, Michael A; Rodin, Rachel E; Bohrson, Craig L; Coulter, Michael E; Barton, Alison R; Kwon, Minseok; Sherman, Maxwell A; Vitzthum, Carl M; Luquette, Lovelace J; Yandava, Chandri N; Yang, Pengwei; Chittenden, Thomas W; Hatem, Nicole E; Ryu, Steven C; Woodworth, Mollie B; Park, Peter J; Walsh, Christopher A

Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network

不同神经元基因组与神经精神疾病的交集:脑体细胞镶嵌网络

McConnell, Michael J; Moran, John V; Abyzov, Alexej; Akbarian, Schahram; Bae, Taejeong; Cortes-Ciriano, Isidro; Erwin, Jennifer A; Fasching, Liana; Flasch, Diane A; Freed, Donald; Ganz, Javier; Jaffe, Andrew E; Kwan, Kenneth Y; Kwon, Minseok; Lodato, Michael A; Mills, Ryan E; Paquola, Apua C M; Rodin, Rachel E; Rosenbluh, Chaggai; Sestan, Nenad; Sherman, Maxwell A; Shin, Joo Heon; Song, Saera; Straub, Richard E; Thorpe, Jeremy; Weinberger, Daniel R; Urban, Alexander E; Zhou, Bo; Gage, Fred H; Lehner, Thomas; Senthil, Geetha; Walsh, Christopher A; Chess, Andrew; Courchesne, Eric; Gleeson, Joseph G; Kidd, Jeffrey M; Park, Peter J; Pevsner, Jonathan; Vaccarino, Flora M

Somatic mutation in single human neurons tracks developmental and transcriptional history

单个人类神经元中的体细胞突变反映了发育和转录历史。

Lodato, Michael A; Woodworth, Mollie B; Lee, Semin; Evrony, Gilad D; Mehta, Bhaven K; Karger, Amir; Lee, Soohyun; Chittenden, Thomas W; D'Gama, Alissa M; Cai, Xuyu; Luquette, Lovelace J; Lee, Eunjung; Park, Peter J; Walsh, Christopher A