Loewer相关文献与解析，生知库 | 链接生命科学的每一步

Wiechens, Elina; Vigliotti, Flavia; Siniuk, Kanstantsin; Schwarz, Robert; Schwab, Katjana; Riege, Konstantin; van Bömmel, Alena; Görlich, Ivonne; Bens, Martin; Sahm, Arne; Groth, Marco; Sammons, Morgan A; Loewer, Alexander; Hoffmann, Steve; Fischer, Martin

信号转导

发表日期：2025

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Decoding stimulus-specific regulation of promoter activity of p53 target genes.

解码p53靶基因启动子活性的刺激特异性调控

期刊:Frontiers in Cell and Developmental Biology

影响因子:4.3

doi:10.3389/fcell.2025.1603603

Vigliotti Flavia, Engelmann Nicolai, Sinzger-D'Angelo Mark, Koeppl Heinz, Loewer Alexander

P53

发表日期：2025

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The p21CIP1-CDK4-DREAM axis is a master regulator of genotoxic stress-induced cellular senescence

p21CIP1-CDK4-DREAM 轴是基因毒性应激诱导细胞衰老的主要调节器

期刊:Nucleic Acids Research

影响因子:16.6

doi:10.1093/nar/gkae426

Ariane Schmidt, Sebastian Allmann, Christian Schwarzenbach, Petra Snyder, Jia-Xuan Chen, Georg Nagel, Anna Schöneis, Birgit Rasenberger, Petra Beli, Alexander Loewer, Thomas G Hofmann, Maja T Tomicic, Markus Christmann

Transcriptional regulators ensuring specific gene expression and decision-making at high TGFβ doses

在高浓度TGFβ条件下，转录调控因子确保特定的基因表达和决策。

期刊:Life Science Alliance

影响因子:3.3

doi:10.26508/lsa.202402859

Laura Hartmann ,Panajot Kristofori ,Congxin Li ,Kolja Becker ,Lorenz Hexemer ,Stefan Bohn ,Sonja Lenhardt ,Sylvia Weiss ,Björn Voss ,Alexander Loewer ,Stefan Legewie

State- and stimulus-specific dynamics of SMAD signaling determine fate decisions in individual cells

SMAD 信号的状态和刺激特异性动态决定单个细胞的命运

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:

doi:10.1073/pnas.2210891120

Stefan Bohn, Lorenz Hexemer, Zixin Huang, Laura Strohmaier, Sonja Lenhardt, Stefan Legewie, Alexander Loewer

Data-based stochastic modeling reveals sources of activity bursts in single-cell TGF-β signaling

基于数据的随机建模揭示了单细胞TGF-β信号传导中活性爆发的来源

期刊:PLoS Computational Biology

影响因子:3.6

doi:10.1371/journal.pcbi.1010266

Kolbe, Niklas; Hexemer, Lorenz; Bammert, Lukas-Malte; Loewer, Alexander; Lukáčová-Medvid'ová, Mária; Legewie, Stefan

Disentangling Pro-mitotic Signaling during Cell Cycle Progression using Time-Resolved Single-Cell Imaging

利用时间分辨单细胞成像技术解析细胞周期进程中的有丝分裂前信号

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2020.03.078

Manuela Benary, Stefan Bohn, Mareen Lüthen, Ilias K Nolis, Nils Blüthgen, Alexander Loewer

A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics

利用单细胞动力学系统性方法解读 p53 信号通路中的串扰

期刊:PLoS Computational Biology

影响因子:3.8

doi:10.1371/journal.pcbi.1007901

Fabian Konrath, Anna Mittermeier, Elena Cristiano, Jana Wolf, Alexander Loewer

Stochastic transcription in the p53-mediated response to DNA damage is modulated by burst frequency

p53 介导的 DNA 损伤反应中的随机转录受爆发频率的调节

期刊:Molecular Systems Biology

影响因子:8.5

doi:10.15252/msb.20199068

Dhana Friedrich, Laura Friedel, Ana Finzel, Andreas Herrmann, Stephan Preibisch, Alexander Loewer

PCNA-Mediated Degradation of p21 Coordinates the DNA Damage Response and Cell Cycle Regulation in Individual Cells

PCNA 介导的 p21 降解协调单个细胞中的 DNA 损伤反应和细胞周期调控

期刊:Cell Reports

影响因子:7.5

doi:10.1016/j.celrep.2019.03.031

Caibin Sheng, Isabella-Hilda Mendler, Sara Rieke, Petra Snyder, Marcel Jentsch, Dhana Friedrich, Barbara Drossel, Alexander Loewer

Gene regulation by convergent promoters

聚合启动子对基因的调控

Decoding stimulus-specific regulation of promoter activity of p53 target genes.

解码p53靶基因启动子活性的刺激特异性调控

The p21CIP1-CDK4-DREAM axis is a master regulator of genotoxic stress-induced cellular senescence

p21CIP1-CDK4-DREAM 轴是基因毒性应激诱导细胞衰老的主要调节器

Transcriptional regulators ensuring specific gene expression and decision-making at high TGFβ doses

在高浓度TGFβ条件下，转录调控因子确保特定的基因表达和决策。

State- and stimulus-specific dynamics of SMAD signaling determine fate decisions in individual cells

SMAD 信号的状态和刺激特异性动态决定单个细胞的命运

Data-based stochastic modeling reveals sources of activity bursts in single-cell TGF-β signaling

基于数据的随机建模揭示了单细胞TGF-β信号传导中活性爆发的来源

Disentangling Pro-mitotic Signaling during Cell Cycle Progression using Time-Resolved Single-Cell Imaging

利用时间分辨单细胞成像技术解析细胞周期进程中的有丝分裂前信号

A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics

利用单细胞动力学系统性方法解读 p53 信号通路中的串扰

Stochastic transcription in the p53-mediated response to DNA damage is modulated by burst frequency

p53 介导的 DNA 损伤反应中的随机转录受爆发频率的调节

PCNA-Mediated Degradation of p21 Coordinates the DNA Damage Response and Cell Cycle Regulation in Individual Cells

PCNA 介导的 p21 降解协调单个细胞中的 DNA 损伤反应和细胞周期调控