Loewer Alexander相关文献与解析，生知库 | 链接生命科学的每一步

Wiechens, Elina; Vigliotti, Flavia; Siniuk, Kanstantsin; Schwarz, Robert; Schwab, Katjana; Riege, Konstantin; van Bömmel, Alena; Görlich, Ivonne; Bens, Martin; Sahm, Arne; Groth, Marco; Sammons, Morgan A; Loewer, Alexander; Hoffmann, Steve; Fischer, Martin

信号转导

发表日期：2025

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Decoding stimulus-specific regulation of promoter activity of p53 target genes.

解码p53靶基因启动子活性的刺激特异性调控

期刊:Frontiers in Cell and Developmental Biology

影响因子:4.3

doi:10.3389/fcell.2025.1603603

Vigliotti Flavia, Engelmann Nicolai, Sinzger-D'Angelo Mark, Koeppl Heinz, Loewer Alexander

P53

发表日期：2025

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Data-based stochastic modeling reveals sources of activity bursts in single-cell TGF-β signaling

基于数据的随机建模揭示了单细胞TGF-β信号传导中活性爆发的来源

期刊:PLoS Computational Biology

影响因子:3.6

doi:10.1371/journal.pcbi.1010266

Kolbe, Niklas; Hexemer, Lorenz; Bammert, Lukas-Malte; Loewer, Alexander; Lukáčová-Medvid'ová, Mária; Legewie, Stefan

Hyperactivation of ATM upon DNA-PKcs inhibition modulates p53 dynamics and cell fate in response to DNA damage.

DNA-PKcs抑制后ATM过度激活，调节p53动态和细胞命运以应对DNA损伤

期刊:Molecular Biology of the Cell

影响因子:2.7

doi:10.1091/mbc.E16-01-0032

Finzel Ana, Grybowski Andrea, Strasen Jette, Cristiano Elena, Loewer Alexander

Differential protein occupancy profiling of the mRNA transcriptome

mRNA转录组的差异蛋白占位谱分析

期刊:Genome Biology

影响因子:9.4

doi:10.1186/gb-2014-15-1-r15

Schueler, Markus; Munschauer, Mathias; Gregersen, Lea Haarup; Finzel, Ana; Loewer, Alexander; Chen, Wei; Landthaler, Markus; Dieterich, Christoph

发表日期：2014

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The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold

单细胞中p53的反应与DNA断裂的数量呈线性相关，且不存在明显的阈值。

期刊:BMC Biology

影响因子:4.5

doi:10.1186/1741-7007-11-114

Loewer, Alexander; Karanam, Ketki; Mock, Caroline; Lahav, Galit

Dynamics of the DNA damage response: insights from live-cell imaging

DNA损伤反应的动态过程：来自活细胞成像的启示

期刊:Briefings in Functional Genomics

影响因子:2.5

doi:10.1093/bfgp/els059

Karanam, Ketki; Loewer, Alexander; Lahav, Galit

Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction

细胞分裂停滞时间延长会触发部分细胞凋亡，导致DNA损伤和p53诱导。

期刊:Molecular Biology of the Cell

影响因子:2.7

doi:10.1091/mbc.E11-09-0781

Orth, James D; Loewer, Alexander; Lahav, Galit; Mitchison, Timothy J

Stimulus-dependent dynamics of p53 in single cells

单细胞中p53的刺激依赖性动态变化

期刊:Molecular Systems Biology

影响因子:7.7

doi:10.1038/msb.2011.20

Batchelor, Eric; Loewer, Alexander; Mock, Caroline; Lahav, Galit

A synthetic-natural hybrid oscillator in human cells

人类细胞中的合成-天然混合振荡器

期刊:Proceedings of the National Academy of Sciences of the United States of America

影响因子:9.1

doi:10.1073/pnas.1005615107

Toettcher, Jared E; Mock, Caroline; Batchelor, Eric; Loewer, Alexander; Lahav, Galit

细胞生物学

发表日期：2010

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Gene regulation by convergent promoters

聚合启动子对基因的调控

Decoding stimulus-specific regulation of promoter activity of p53 target genes.

解码p53靶基因启动子活性的刺激特异性调控

Data-based stochastic modeling reveals sources of activity bursts in single-cell TGF-β signaling

基于数据的随机建模揭示了单细胞TGF-β信号传导中活性爆发的来源

Hyperactivation of ATM upon DNA-PKcs inhibition modulates p53 dynamics and cell fate in response to DNA damage.

DNA-PKcs抑制后ATM过度激活，调节p53动态和细胞命运以应对DNA损伤

Differential protein occupancy profiling of the mRNA transcriptome

mRNA转录组的差异蛋白占位谱分析

The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold

单细胞中p53的反应与DNA断裂的数量呈线性相关，且不存在明显的阈值。

Dynamics of the DNA damage response: insights from live-cell imaging

DNA损伤反应的动态过程：来自活细胞成像的启示

Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction

细胞分裂停滞时间延长会触发部分细胞凋亡，导致DNA损伤和p53诱导。

Stimulus-dependent dynamics of p53 in single cells

单细胞中p53的刺激依赖性动态变化

A synthetic-natural hybrid oscillator in human cells

人类细胞中的合成-天然混合振荡器