A potent epigenetic editor targeting human PCSK9 for durable reduction of low-density lipoprotein cholesterol levels
一种靶向人类PCSK9的强效表观遗传编辑剂,可持久降低低密度脂蛋白胆固醇水平。
期刊:Nature Medicine
影响因子:50
doi:10.1038/s41591-025-03508-x
Tremblay, Frederic; Xiong, Qiang; Shah, Shrijal S; Ko, Chih-Wei; Kelly, Kenneth; Morrison, Mary S; Giancarlo, Cristiana; Ramirez, Ricardo N; Hildebrand, Erica M; Voytek, Sarah B; El Sebae, Gabriel K; Wright, Shane H; Lofgren, Liam; Clarkson, Scott; Waters, Christine; Linder, Samantha J; Liu, Songlei; Eom, Taesun; Parikh, Shefal; Weber, Yuki; Martinez, Salette; Malyala, Padma; Abubucker, Sahar; Friedland, Ari E; Maeder, Morgan L; Lombardo, Angelo; Myer, Vic E; Jaffe, Aron B