日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Timing matters: early administration of a high-affinity antibody targeting the tau repeat domain prevents aggregation in a mouse tauopathy model

时机至关重要:在小鼠tau蛋白病模型中,早期注射靶向tau重复结构域的高亲和力抗体可预防聚集。

Penny, Lewis K; Arastoo, Mohammad; Lofthouse, Richard; Abdallah, Aya; Imoesi, Peter I; Schwab, Karima; Shiells, Helen; Melis, Valeria; Riedel, Gernot; Harrington, Charles R; Wischik, Claude M; Porter, Andrew; Palliyil, Soumya

Hydromethylthionine sustains truncated tau-dependent inflammation-lowering effects in mouse brain.

氢甲基硫氨酸在小鼠脑中维持截短的 tau 依赖性炎症降低作用

Santos Renato X, Lee Sophie H, Lofthouse Richard, Melis Valeria, Robinson Lianne, Leith Michael, Dreesen Eline, Armstrong Paul, Vorley Thomas, Goatman Elizabeth A, Hull Claire, Riedel Gernot, Wischik Claude M, Harrington Charles R

Quantification of plasma tau species containing the proline-rich region as a biomarker in Alzheimer's disease.

血浆中含有富含脯氨酸区域的 tau 蛋白种类的定量分析,作为阿尔茨海默病的生物标志物。

Arastoo Mohammad, Penny Lewis K, Lofthouse Richard, Hitchcock Aaron, Moelders Anna, Szalma Sona, Porter Andrew, Palliyil Soumya, Harrington Charles R, Wischik Claude M

Calcium regulation of muscle spindle mechanosensory afferent function

钙调节肌肉梭机械感觉传入功能

Simon, Anna; Lofthouse, Richard A; Miti, Philip; Giuraniuc, Claudiu V; Banks, Robert W; Bewick, Guy S

Considerations for biomarker strategies in clinical trials investigating tau-targeting therapeutics for Alzheimer's disease

针对阿尔茨海默病tau蛋白靶向疗法的临床试验中生物标志物策略的考量

Penny, Lewis K; Lofthouse, Richard; Arastoo, Mohammad; Porter, Andy; Palliyil, Soumya; Harrington, Charles R; Wischik, Claude M

Utility of Blood-Based Tau Biomarkers for Mild Cognitive Impairment and Alzheimer's Disease: Systematic Review and Meta-Analysis

血液中tau蛋白生物标志物在轻度认知障碍和阿尔茨海默病中的应用:系统评价和荟萃分析

Zabala-Findlay, Alex; Penny, Lewis K; Lofthouse, Richard A; Porter, Andrew J; Palliyil, Soumya; Harrington, Charles R; Wischik, Claude M; Arastoo, Mohammad

Current Progress and Future Directions for Tau-Based Fluid Biomarker Diagnostics in Alzheimer's Disease

基于Tau蛋白的体液生物标志物诊断在阿尔茨海默病中的最新进展和未来方向

Arastoo, Mohammad; Lofthouse, Richard; Penny, Lewis K; Harrington, Charles R; Porter, Andy; Wischik, Claude M; Palliyil, Soumya