日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Electron microscopy evidence of gadolinium toxicity being mediated through cytoplasmic membrane dysregulation

电子显微镜证据表明,钆的毒性是通过细胞质膜功能紊乱介导的。

Arino, Trevor; Faulkner, David; Bustillo, Karen C; An, Dahlia D; Jorgens, Danielle; Hébert, Solène; McKinley, Carla; Proctor, Michael; Loguinov, Alex; Vulpe, Christopher; Abergel, Rebecca J

Genome-wide CRISPR/Cas9 screen identifies etoposide response modulators associated with clinical outcomes in pediatric AML

全基因组 CRISPR/Cas9 筛选确定与儿童 AML 临床结果相关的依托泊苷反应调节剂

Nam H K Nguyen, Roya Rafiee, Abderrahmane Tagmount, Amin Sobh, Alex Loguinov, Angelica K de Jesus Sosa, Abdelrahman H Elsayed, Mohammed Gbadamosi, Nathan Seligson, Christopher R Cogle, Jeffery Rubnitz, Raul Ribeiro, James Downing, Xueyuan Cao, Stanley B Pounds, Christopher D Vulpe, Jatinder K Lamba

Overcoming Gemcitabine Resistance in Pancreatic Cancer Using the BCL-XL-Specific Degrader DT2216

使用 BCL-XL 特异性降解剂 DT2216 克服胰腺癌的吉西他滨耐药性

Dinesh Thummuri #, Sajid Khan #, Patrick W Underwood #, Peiyi Zhang, Janet Wiegand, Xuan Zhang, Vivekananda Budamagunta, Amin Sobh, Abderrahmane Tagmount, Alexander Loguinov, Andrea N Riner, Ashwin S Akki, Elizabeth Williamson, Robert Hromas, Christopher D Vulpe, Guangrong Zheng, Jose G Trevino, Dao

Treatment with HIV-Protease Inhibitor Nelfinavir Identifies Membrane Lipid Composition and Fluidity as a Therapeutic Target in Advanced Multiple Myeloma

使用 HIV 蛋白酶抑制剂奈非那韦治疗可确定膜脂质组成和流动性是晚期多发性骨髓瘤的治疗靶点

Lenka Besse #, Andrej Besse #, Sara C Stolze, Amin Sobh, Esther A Zaal, Alwin J van der Ham, Mario Ruiz, Santosh Phuyal, Lorina Büchler, Marc Sathianathan, Bogdan I Florea, Jan Borén, Marcus Ståhlman, Julia Huber, Arnold Bolomsky, Heinz Ludwig, J Thomas Hannich, Alex Loguinov, Bart Everts, Celia R B

Genome-wide toxicogenomic study of the lanthanides sheds light on the selective toxicity mechanisms associated with critical materials

对镧系元素的全基因组毒理基因组学研究揭示了与关键物质相关的选择性毒性机制

Pallares, Roger M; Faulkner, David; An, Dahlia D; Hébert, Solène; Loguinov, Alex; Proctor, Michael; Villalobos, Jonathan A; Bjornstad, Kathleen A; Rosen, Chris J; Vulpe, Christopher; Abergel, Rebecca J

Applying genome-wide CRISPR to identify known and novel genes and pathways that modulate formaldehyde toxicity

应用全基因组 CRISPR 技术鉴定已知和新的调控甲醛毒性的基因和通路

Zhao, Yun; Wei, Linqing; Tagmount, Abderrahmane; Loguinov, Alex; Sobh, Amin; Hubbard, Alan; McHale, Cliona M; Chang, Christopher J; Vulpe, Chris D; Zhang, Luoping

Functional Pathway Identification With CRISPR/Cas9 Genome-wide Gene Disruption in Human Dopaminergic Neuronal Cells Following Chronic Treatment With Dieldrin

长期接受狄氏剂治疗后,利用 CRISPR/Cas9 全基因组基因破坏技术识别人类多巴胺能神经元细胞的功能通路

Max Russo, Amin Sobh, Ping Zhang, Alex Loguinov, Abderrahmane Tagmount, Chris D Vulpe, Bin Liu

Functional Profiling Identifies Determinants of Arsenic Trioxide Cellular Toxicity

功能分析揭示三氧化二砷细胞毒性的决定因素

Sobh, Amin; Loguinov, Alex; Yazici, Gulce Naz; Zeidan, Rola S; Tagmount, Abderrahmane; Hejazi, Nima S; Hubbard, Alan E; Zhang, Luoping; Vulpe, Chris D

Genome-Wide CRISPR Screening Identifies the Tumor Suppressor Candidate OVCA2 As a Determinant of Tolerance to Acetaldehyde

全基因组 CRISPR 筛选鉴定出肿瘤抑制候选基因 OVCA2,该基因是乙醛耐受性的决定因素。

Amin Sobh ,Alex Loguinov ,Alessia Stornetta ,Silvia Balbo ,Abderrahmane Tagmount ,Luoping Zhang ,Chris D Vulpe

Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin

多铜氧化铁酶 Hephaestin 和铜蓝蛋白双敲除小鼠出现严重铁代谢缺陷

Brie K Fuqua, Yan Lu, David M Frazer, Deepak Darshan, Sarah J Wilkins, Linda Dunn, Alex V Loguinov, Scott C Kogan, Pavle Matak, Huijun Chen, Joshua L Dunaief, Chris D Vulpe, Gregory J Anderson