Loss of metabolic fitness drives tumor resistance after CAR-NK cell therapy and can be overcome by cytokine engineering
代谢适应性的丧失是CAR-NK细胞疗法后肿瘤产生耐药性的主要原因,而细胞因子工程可以克服这一问题。
期刊:Science Advances
影响因子:12.5
doi:10.1126/sciadv.add6997
Li, Li; Mohanty, Vakul; Dou, Jinzhuang; Huang, Yuefan; Banerjee, Pinaki P; Miao, Qi; Lohr, Jens G; Vijaykumar, Tushara; Frede, Julia; Knoechel, Birgit; Muniz-Feliciano, Luis; Laskowski, Tamara J; Liang, Shaoheng; Moyes, Judy S; Nandivada, Vandana; Basar, Rafet; Kaplan, Mecit; Daher, May; Liu, Enli; Li, Ye; Acharya, Sunil; Lin, Paul; Shanley, Mayra; Rafei, Hind; Marin, David; Mielke, Stephan; Champlin, Richard E; Shpall, Elizabeth J; Chen, Ken; Rezvani, Katayoun
肿瘤
肿瘤免疫
代谢
细胞生物学
CAR-NK
免疫/内分泌