日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Ligand-specific activation trajectories dictate GPCR signalling in cells.

配体特异性激活轨迹决定细胞内的 GPCR 信号传导。

Thomas Romy, Jacoby Pauline S, De Faveri Chiara, Derieux Cécile, Liebing Aenne-Dorothea, Melkes Barbora, Martini Hans-Joachim, Bermúdez Marcel, Stäubert Claudia, Lohse Martin J, Coin Irene, Bock Andreas

MRAP2 modifies the signaling and oligomerization state of the melanocortin-4 receptor.

MRAP2 改变黑皮质素-4 受体的信号传导和寡聚化状态

Sohail Iqra, Laurin Suli-Anne, Kleinau Gunnar, Chunilal Vidicha, Morton Andrew, Brenlla Alfonso, Kagiali Zeynep Cansu Uretmen, Blouin Marie-José, Tello Javier A, Beck-Sickinger Annette G, Lohse Martin J, Scheerer Patrick, Bouvier Michel, McCormick Peter, Annibale Paolo, Biebermann Heike

Disruption of constitutive CXCR4 oligomers impairs oncogenic properties in lymphoid neoplasms.

CXCR4 寡聚体的组成破坏会损害淋巴瘤的致癌特性

Mobach Simon, Bergkamp Nick D, Ma Ziliang, Haselager Marco V, Anbuhl Stephanie M, Jurriens Daphne, van den Bor Jelle, Wang Ziming, Crudden Caitrin, Roos Jamie L, Perez Almeria Claudia V, Boergonje Rick A, Lohse Martin J, Bosma Reggie, Eldering Eric, Siderius Marco, Wu Wei, Spaargaren Marcel, Tonino Sanne H, Kater Arnon P, Smit Martine J, Heukers Raimond

Visualization of β-adrenergic receptor dynamics and differential localization in cardiomyocytes

心肌细胞中β-肾上腺素能受体动力学和差异定位的可视化

Bathe-Peters, Marc; Gmach, Philipp; Boltz, Horst-Holger; Einsiedel, Jürgen; Gotthardt, Michael; Hübner, Harald; Gmeiner, Peter; Lohse, Martin J; Annibale, Paolo

Differential Signaling Profiles of MC4R Mutations with Three Different Ligands

MC4R突变体与三种不同配体的差异信号传导谱

Paisdzior, Sarah; Dimitriou, Ioanna Maria; Schöpe, Paul Curtis; Annibale, Paolo; Scheerer, Patrick; Krude, Heiko; Lohse, Martin J; Biebermann, Heike; Kühnen, Peter

Unmasking features of the auto-epitope essential for β(1) -adrenoceptor activation by autoantibodies in chronic heart failure

揭示慢性心力衰竭中自身抗体激活β(1)-肾上腺素受体所必需的自身表位特征

Wölfel, Angela; Sättele, Mathias; Zechmeister, Christina; Nikolaev, Viacheslav O; Lohse, Martin J; Boege, Fritz; Jahns, Roland; Boivin-Jahns, Valérie

Linescan microscopy data to extract diffusion coefficient of a fluorescent species using a commercial confocal microscope

利用商用共聚焦显微镜,通过线扫描显微镜数据提取荧光物质的扩散系数

Bathe-Peters, Marc; Gmach, Philipp; Annibale, Paolo; Lohse, Martin J

Stepwise activation of a class C GPCR begins with millisecond dimer rearrangement

C类GPCR的逐步激活始于毫秒级的二聚体重排。

Grushevskyi, Eugene O; Kukaj, Taulant; Schmauder, Ralf; Bock, Andreas; Zabel, Ulrike; Schwabe, Tina; Benndorf, Klaus; Lohse, Martin J

Molecular details of dimerization kinetics reveal negligible populations of transient µ-opioid receptor homodimers at physiological concentrations.

二聚化动力学的分子细节表明,在生理浓度下,瞬时μ-阿片受体同源二聚体的数量可以忽略不计

Meral Derya, Provasi Davide, Prada-Gracia Diego, Möller Jan, Marino Kristen, Lohse Martin J, Filizola Marta

β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle

β-Arrestin生物传感器揭示了一种快速的、受体依赖性的激活/失活循环

Nuber, Susanne; Zabel, Ulrike; Lorenz, Kristina; Nuber, Andreas; Milligan, Graeme; Tobin, Andrew B; Lohse, Martin J; Hoffmann, Carsten