日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Minimal N -methylated and stapled peptide inhibitors of the autophagy protein GABARAP

自噬蛋白GABARAP的最小N-甲基化和环状肽抑制剂

McDonald, Imani; Wilms, Joana A; Cardi, Nicholas; Engstrom, Alexander; Miao, Jiayuan; Willbold, Dieter; Lin, Yu-Shan; Lokey, R Scott; Weiergräber, Oliver H; Kritzer, Joshua A

Triazine Macrocycle Libraries: Synthesis, logD Prediction, and a Surprisingly Hydrophobic, Membrane-Permeable Diamine

三嗪大环化合物库:合成、logD值预测以及一种出人意料的疏水性膜渗透性二胺

Stokes, Gretel A; Patterson-Gardner, Casey J; Engstrom, Alexander M; Menke, Alexander J; Vardhan Reddy, K Harsha; Lokey, R Scott; Simanek, Eric E

MOAST: Mechanism of Action Similarity Tool

MOAST:作用机制相似性工具

Lohith, Akshar; Terciano, Derfel; Murray, Adam; MacMillan, John B; Lokey, R Scott

Cell painting in activated cells illuminates phenotypic dark space and uncovers novel drug mechanisms of action.

活化细胞中的细胞涂画可以揭示表型暗区,并发现新的药物作用机制

Zietek Matylda A, Lohith Akshar, Terciano Derfel, Rabbitts Beverley M, Khadilkar Aswad, MacMillan John B, Lokey R Scott

Membrane Permeability in a Large Macrocyclic Peptide Driven by a Saddle-Shaped Conformation

马鞍形构象驱动的大环肽的膜通透性

Justin H Faris, Emel Adaligil, Nataliya Popovych, Satoshi Ono, Mifune Takahashi, Huy Nguyen, Emile Plise, Jaru Taechalertpaisarn, Hsiau-Wei Lee, Michael F T Koehler, Christian N Cunningham, R Scott Lokey

High-Content Image-Based Screening and Deep Learning for the Detection of Anti-Inflammatory Drug Leads

基于高内涵图像的筛选和深度学习在抗炎药物先导化合物检测中的应用

Lau, Tannia A; Mair, Elmar; Rabbitts, Beverley M; Lohith, Akshar; Lokey, R Scott

Evaluation of the Centers for Disease Control and Prevention's Essentials for Parenting Toddlers and Preschoolers on parent behavioral outcomes

对美国疾病控制与预防中心《幼儿及学龄前儿童养育要点》对父母行为结果的评估

Morgan, Mary Harbert C; Herbst, Jeffrey H; Fortson, Beverly L; Shortt, Joann Wu; Willis, Leigh A; Lokey, Colby; Smith Slep, Amy M; Lorber, Michael F; Huber-Krum, Sarah

Amide-to-ester substitution as a stable alternative to N-methylation for increasing membrane permeability in cyclic peptides.

酰胺到酯的取代是提高环肽膜渗透性的稳定替代方法,可替代 N-甲基化

Hosono Yuki, Uchida Satoshi, Shinkai Moe, Townsend Chad E, Kelly Colin N, Naylor Matthew R, Lee Hsiau-Wei, Kanamitsu Kayoko, Ishii Mayumi, Ueki Ryosuke, Ueda Takumi, Takeuchi Koh, Sugita Masatake, Akiyama Yutaka, Lokey Scott R, Morimoto Jumpei, Sando Shinsuke

DNA-Compatible Conditions for the Formation of N-Methyl Peptide Bonds

DNA 兼容的 N-甲基肽键形成条件

Panpan Zhang, Grant Koch, Yankun Zhang, Kevin Yang, R Scott Lokey

Inability to move one's face dampens facial expression perception

面部活动受限会削弱对面部表情的感知。

Japee, Shruti; Jordan, Jessica; Licht, Judith; Lokey, Savannah; Chen, Gang; Snow, Joseph; Jabs, Ethylin Wang; Webb, Bryn D; Engle, Elizabeth C; Manoli, Irini; Baker, Chris; Ungerleider, Leslie G