日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Minimal N -methylated and stapled peptide inhibitors of the autophagy protein GABARAP

自噬蛋白GABARAP的最小N-甲基化和环状肽抑制剂

McDonald, Imani; Wilms, Joana A; Cardi, Nicholas; Engstrom, Alexander; Miao, Jiayuan; Willbold, Dieter; Lin, Yu-Shan; Lokey, R Scott; Weiergräber, Oliver H; Kritzer, Joshua A

Triazine Macrocycle Libraries: Synthesis, logD Prediction, and a Surprisingly Hydrophobic, Membrane-Permeable Diamine

三嗪大环化合物库:合成、logD值预测以及一种出人意料的疏水性膜渗透性二胺

Stokes, Gretel A; Patterson-Gardner, Casey J; Engstrom, Alexander M; Menke, Alexander J; Vardhan Reddy, K Harsha; Lokey, R Scott; Simanek, Eric E

MOAST: Mechanism of Action Similarity Tool

MOAST:作用机制相似性工具

Lohith, Akshar; Terciano, Derfel; Murray, Adam; MacMillan, John B; Lokey, R Scott

Cell painting in activated cells illuminates phenotypic dark space and uncovers novel drug mechanisms of action.

活化细胞中的细胞涂画可以揭示表型暗区,并发现新的药物作用机制

Zietek Matylda A, Lohith Akshar, Terciano Derfel, Rabbitts Beverley M, Khadilkar Aswad, MacMillan John B, Lokey R Scott

High-Content Image-Based Screening and Deep Learning for the Detection of Anti-Inflammatory Drug Leads

基于高内涵图像的筛选和深度学习在抗炎药物先导化合物检测中的应用

Lau, Tannia A; Mair, Elmar; Rabbitts, Beverley M; Lohith, Akshar; Lokey, R Scott

Reevaluation of a Bicyclic Pyrazoline as a Selective 15-Lipoxygenase V-Type Activator Possessing Fatty Acid Specificity

对一种具有脂肪酸特异性的双环吡唑啉作为选择性15-脂氧合酶V型激活剂的重新评价

van Hoorebeke, Christopher; Yang, Kevin; Mussetter, Samuel J; Koch, Grant; Rutz, Natalie; Lokey, R Scott; Crews, Phillip; Holman, Theodore R

Drug-Like Properties in Macrocycles above MW 1000: Backbone Rigidity versus Side-Chain Lipophilicity

分子量大于1000的大环化合物的类药性质:主链刚性与侧链亲脂性

Furukawa, Akihiro; Schwochert, Joshua; Pye, Cameron R; Asano, Daigo; Edmondson, Quinn D; Turmon, Alexandra C; Klein, Victoria G; Ono, Satoshi; Okada, Okimasa; Lokey, R Scott

Conformation and Permeability: Cyclic Hexapeptide Diastereomers

构象与渗透性:环状六肽非对映异构体

Ono, Satoshi; Naylor, Matthew R; Townsend, Chad E; Okumura, Chieko; Okada, Okimasa; Lokey, R Scott

Macrophage Cytological Profiling and Anti-Inflammatory Drug Discovery

巨噬细胞细胞学分析与抗炎药物发现

Lau, Tannia A; Bray, Walter M; Lokey, R Scott

Retrospective analysis of natural products provides insights for future discovery trends

对天然产物的回顾性分析可为未来的发现趋势提供见解

Pye, Cameron R; Bertin, Matthew J; Lokey, R Scott; Gerwick, William H; Linington, Roger G