日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Dynamic and structural insights into allosteric regulation on MKP5 a dual-specificity phosphatase

对双特异性磷酸酶 MKP5 变构调节的动态和结构见解

Skeens, Erin; Maschietto, Federica; Manjula, Ramu; Shillingford, Shanelle; Murphy, James; Lolis, Elias J; Batista, Victor S; Bennett, Anton M; Lisi, George P

In vivo synergistic enhancement of MIF-mediated inflammation in acute lung injury by the plant ortholog Arabidopsis MDL1

植物同源基因拟南芥MDL1在体内协同增强MIF介导的急性肺损伤炎症反应

Spiller, Lukas; Zhang, Lin; Gerra, Simona; Stoppe, Christian; Scheiermann, Patrick; Calandra, Thierry; Lolis, Elias; Panstruga, Ralph; Bernhagen, Jürgen; Hoffmann, Adrian

Iguratimod, an allosteric inhibitor of macrophage migration inhibitory factor (MIF), prevents mortality and oxidative stress in a murine model of acetaminophen overdose

伊古拉莫德(Iguratimod)是一种巨噬细胞迁移抑制因子(MIF)的变构抑制剂,可预防对乙酰氨基酚过量小鼠模型中的死亡和氧化应激。

Bloom, Joshua; Pantouris, Georgios; He, Mingzhu; Aljabari, Bayan; Mishra, Lopa; Manjula, Ramu; Parkins, Andrew; Lolis, Elias J; Al-Abed, Yousef

Valproate-coenzyme A conjugate blocks opening of receptor binding domains in the spike trimer of SARS-CoV-2 through an allosteric mechanism

丙戊酸-辅酶A缀合物通过变构机制阻断SARS-CoV-2刺突蛋白三聚体中受体结合域的开放。

Maschietto, Federica; Qiu, Tianyin; Wang, Jimin; Shi, Yuanjun; Allen, Brandon; Lisi, George P; Lolis, Elias; Batista, Victor S

Defining the structure-activity relationship for a novel class of allosteric MKP5 inhibitors

确定一类新型变构MKP5抑制剂的构效关系

Gannam, Zira T K; Jamali, Haya; Kweon, Oh Sang; Herrington, James; Shillingford, Shanelle R; Papini, Christina; Gentzel, Erik; Lolis, Elias; Bennett, Anton M; Ellman, Jonathan A; Anderson, Karen S

How to correct relative voxel scale factors for calculations of vector-difference Fourier maps in cryo-EM

如何校正冷冻电镜中矢量差分傅里叶图计算的相对体素尺度因子

Wang, Jimin; Liu, Jinchan; Gisriel, Christopher J; Wu, Shenping; Maschietto, Federica; Flesher, David A; Lolis, Elias; Lisi, George P; Brudvig, Gary W; Xiong, Yong; Batista, Victor S

Suppression of Plasmodium MIF-CD74 signaling protects against severe malaria

抑制疟原虫MIF-CD74信号传导可预防重症疟疾

Baeza Garcia, Alvaro; Siu, Edwin; Du, Xin; Leng, Lin; Franke-Fayard, Blandine; Janse, Chris J; Howland, Shanshan W; Rénia, Laurent; Lolis, Elias; Bucala, Richard

Computational insights into the membrane fusion mechanism of SARS-CoV-2 at the cellular level

细胞水平上SARS-CoV-2膜融合机制的计算研究

Wang, Jimin; Maschietto, Federica; Guberman-Pfeffer, Matthew J; Reiss, Krystle; Allen, Brandon; Xiong, Yong; Lolis, Elias; Batista, Victor S

A structurally preserved allosteric site in the MIF superfamily affects enzymatic activity and CD74 activation in D-dopachrome tautomerase

MIF超家族中结构保守的变构位点影响D-多巴色素互变酶的酶活性和CD74活化。

Chen, Emily; Reiss, Krystle; Shah, Dilip; Manjula, Ramu; Allen, Brandon; Murphy, Eva L; Murphy, James W; Batista, Victor S; Bhandari, Vineet; Lolis, Elias J; Lisi, George P

High-Throughput Screening of a Functional Human CXCL12-CXCR4 Signaling Axis in a Genetically Modified S. cerevisiae: Discovery of a Novel Up-Regulator of CXCR4 Activity

利用基因改造的酿酒酵母进行高通量筛选,鉴定功能性人CXCL12-CXCR4信号轴:发现一种新型CXCR4活性上调因子

Murphy, James W; Rajasekaran, Deepa; Merkel, Janie; Skeens, Erin; Keeler, Camille; Hodsdon, Michael E; Lisi, George P; Lolis, Elias