日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Lentiviral Gene Therapy with CD34+ Hematopoietic Cells for Hemophilia A

利用CD34+造血细胞进行慢病毒基因治疗A型血友病

Srivastava, Alok; Abraham, Aby; Aboobacker, Fouzia; Singh, Gurbind; Geevar, Tulasi; Kulkarni, Uday; Selvarajan, Sushil; Korula, Anu; Dave, Rutvi Gautam; Shankar, Mohana; Singh, Abraham S; Jeba, Anbu; Kumaar, Navien; Benjamin, Christopher; Lakshmi, Kavitha M; Srivastava, Vivi Miriam; Shaji, Ramachandran V; Nair, Sukesh C; Brown, Harrison C; Denning, Gabriela; Lollar, Pete; Doering, Christopher B; Spencer, Trent

Persistent splenic-derived IgMs preferentially recognize factor VIII A2 and C2 domain epitopes but do not alter antibody production

持续存在的脾脏来源IgM优先识别因子VIII A2和C2结构域表位,但不改变抗体产生。

York, Elizabeth S; Dratch, Benjamin D; Ito, Jasmine; Horwitz, Samantha M; Emamian, Sahand; Ambarian, Joseph A; Gill, Surinder; Jones, Jayre; Chonat, Satheesh; Lollar, Pete; Meeks, Shannon L; Davis, Katherine M; Batsuli, Glaivy

Conformational activation and inhibition of von Willebrand factor by targeting its autoinhibitory module

通过靶向其自身抑制模块来激活和抑制血管性血友病因子构象

Arce, Nicholas A; Markham-Lee, Zoe; Liang, Qian; Najmudin, Shabir; Legan, Emily R; Dean, Gabrielle; Su, Ally J; Wilson, Moriah S; Sidonio, Robert F; Lollar, Pete; Emsley, Jonas; Li, Renhao

Structural basis for inhibition of coagulation factor VIII reveals a shared antigenic hotspot on the C1 domain

凝血因子VIII抑制的结构基础揭示了C1结构域上的一个共同抗原热点。

Childers, Kenneth C; Cowper, Ben; Vaughan, Jordan D; McGill, Juliet R; Davulcu, Omar; Lollar, Pete; Doering, Christopher B; Coxon, Carmen H; Spiegel, Paul C Jr

Nanobody activator improves sensitivity of the von Willebrand factor activity assay to multimer size

纳米抗体激活剂提高了血管性血友病因子活性检测对多聚体大小的敏感性。

Liang, Qian; Parker, Ernest T; Dean, Gabrielle; Karpen, Matthew S; Wu, Yujia; Wang, Xuefeng; Di Paola, Jorge; Maier, Cheryl L; Meeks, Shannon L; Lollar, Pete; Sidonio, Robert F; Li, Renhao

Structure of coagulation factor VIII bound to a patient-derived anti-C1 domain antibody inhibitor

凝血因子VIII与患者来源的抗C1结构域抗体抑制剂结合的结构

Childers, Kenneth C; Avery, Nathan G; Estrada Alamo, Kevin A; Davulcu, Omar; Haynes, Rose Marie; Lollar, Pete; Doering, Christopher B; Coxon, Carmen H; Spiegel, P Clint

pH-dependent conformation of multimeric von Willebrand factor

多聚体血管性血友病因子的pH依赖性构象

Smith, Ian W; Parker, Ernest T; Lollar, Pete

Nonhuman glycans can regulate anti-factor VIII antibody formation in mice

非人源聚糖可以调节小鼠体内抗VIII因子抗体的形成。

Arthur, Connie M; Zerra, Patricia E; Shin, Sooncheon; Wang, Jianmei; Song, Xeuzheng; Doering, Christopher B; Lollar, Pete; Meeks, Shannon; Stowell, Sean R

Desialylation of O-glycans activates von Willebrand factor by destabilizing its autoinhibitory module

O-聚糖的去唾液酸化通过破坏其自身抑制模块来激活血管性血友病因子。

Voos, Kayleigh M; Cao, Wenpeng; Arce, Nicholas A; Legan, Emily R; Wang, Yingchun; Shajahan, Asif; Azadi, Parastoo; Lollar, Pete; Zhang, Xiaohui Frank; Li, Renhao

Subunit Flexibility of Multimeric von Willebrand Factor/Factor VIII Complexes

多聚体血管性血友病因子/因子VIII复合物的亚基柔性

Parker, Ernest T; Haberichter, Sandra L; Lollar, Pete