日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Electrophysiological and Proteomic Evidence of Protease-Mediated Pro-nociceptive Signaling in Inflammatory Bowel Disease Patients

炎症性肠病患者中蛋白酶介导的促伤害感受信号的电生理和蛋白质组学证据

期刊:Journal of Neuroscience
影响因子:4
doi:10.1523/JNEUROSCI.0220-25.2025
Wood, Hannah M; Abu Omar, Amal; Baker, Corey C; Alward, Taylor A; Ziegler, Alexander R; Shi, Yun; Nakhle, Rita; Jaramillo-Polanco, Josue; Lopez-Lopez, Cintya; Morissette, Celine; Vanner, Stephen J; Sheth, Prameet M; Edgington Mitchell, Laura E; Reed, David E; Lomax, Alan E
信号转导
炎症/感染
炎症
发表日期：2026
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ENDOSOMAL SIGNALING OF PROTEASE-ACTIVATED RECEPTOR-2 AMPLIFIES HISTAMINE-INDUCED PAIN OF IRRITABLE BOWEL SYNDROME

蛋白酶激活受体2的内体信号传导可放大组胺诱发的肠易激综合征疼痛

期刊:
影响因子:
doi:10.64898/2026.01.30.702691
Jimenez-Vargas, Nestor N; Sokrat, Badr; Gilmour, Daniella A; Pessano, Maria F; Davidson, Steve; Schmidt, Brian L; Reed, David E; Lomax, Alan E; Vanner, Stephen J; Bunnett, Nigel W
信号转导
肠易激综合征
发表日期：2026
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A Bacteroides fragilis protease activates host PAR(2) to induce intestinal pain and inflammation.

脆弱拟杆菌蛋白酶激活宿主PAR(2)，诱发肠道疼痛和炎症。

期刊:Cell Host & Microbe
影响因子:18.7
doi:10.1016/j.chom.2025.09.010
Lakemeyer Markus, Latorre Rocco, Blazkova Kristyna, Wood Hannah M, Jensen Dane D, Shakil Nayab, Thomas Scott C, Saxena Deepak, Mulpuri Yatendra, Poolman David, Duran Paz, Keller Laura J, Reed David E, Schmidt Brian L, Jiménez-Vargas Néstor N, Xu Fangxi, Lomax Alan E, Bunnett Nigel W, Bogyo Matthew
炎症/感染
炎症
发表日期：2025
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A pH-sensitive opioid does not exhibit analgesic tolerance in a mouse model of colonic inflammation

在小鼠结肠炎症模型中，一种pH敏感型阿片类药物未表现出镇痛耐受性。

期刊:British Journal of Pharmacology
影响因子:7.7
doi:10.1111/bph.17363
Degro, Claudius E; Jiménez-Vargas, Nestor Nivardo; Guzman-Rodriguez, Mabel; Schincariol, Hailey; Tsang, Quentin; Reed, David E; Lomax, Alan E; Bunnett, Nigel W; Stein, Christoph; Vanner, Stephen J
炎症/感染
结肠炎
炎症
肠炎
发表日期：2025
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Probing the activity of cysteine cathepsins in inflammatory bowel diseases

探究半胱氨酸蛋白酶在炎症性肠病中的活性

期刊:Scientific Reports
影响因子:3.9
doi:10.1038/s41598-025-32489-7
Anderson, Bethany M; Ziegler, Alexander R; Campden, Rhiannon I; Wu, Hongyi; Xu, Bangyan; McQuade, Rachel M; Carbone, Simona E; Poole, Daniel P; Lomax, Alan E; Reed, David E; Vanner, Stephen J; Yates, Robin M; Bunnett, Nigel W; Edgington-Mitchell, Laura E
炎症/感染
炎症
发表日期：2025
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Emerging therapeutic approaches for treating abdominal pain

治疗腹痛的新兴疗法

期刊:Journal of the Canadian Association of Gastroenterology
影响因子:2.7
doi:10.1093/jcag/gwaf016
Jimenez-Vargas, Nestor N; Parkar, Nabil; Takami, Kaede; Wood, Hannah M; Lomax, Alan E; Reed, David E; Vanner, Stephen J
发表日期：2025
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Identification of a secreted protease from Bacteroides fragilis that induces intestinal pain and inflammation by cleavage of PAR(2)

从脆弱拟杆菌中鉴定出一种分泌蛋白酶，该蛋白酶通过切割 PAR(2) 诱发肠道疼痛和炎症

期刊:
影响因子:
doi:10.1101/2025.01.15.633241
Lakemeyer, Markus; Latorre, Rocco; Blazkova, Kristyna; Jensen, Dane; Wood, Hannah M; Shakil, Nayab; Thomas, Scott C; Saxena, Deepak; Mulpuri, Yatendra; Poolman, David; de Haro, Paz Duran; Keller, Laura J; Reed, David E; Schmidt, Brian L; Lomax, Alan E; Bunnett, Nigel W; Bogyo, Matthew
炎症/感染
炎症
发表日期：2025
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The emerging roles of bacterial proteases in intestinal diseases

细菌蛋白酶在肠道疾病中的新兴作用

期刊:Gut Microbes
影响因子:11
doi:10.1080/19490976.2023.2181922
Caminero, Alberto; Guzman, Mabel; Libertucci, Josie; Lomax, Alan E
微生物学
发表日期：2023
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Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain

δ阿片受体的内体信号传导是一种内源性机制，也是缓解炎症性疼痛的治疗靶点。

期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2000500117
Jimenez-Vargas, Nestor N; Gong, Jing; Wisdom, Matthew J; Jensen, Dane D; Latorre, Rocco; Hegron, Alan; Teng, Shavonne; DiCello, Jesse J; Rajasekhar, Pradeep; Veldhuis, Nicholas A; Carbone, Simona E; Yu, Yang; Lopez-Lopez, Cintya; Jaramillo-Polanco, Josue; Canals, Meritxell; Reed, David E; Lomax, Alan E; Schmidt, Brian L; Leong, Kam W; Vanner, Stephen J; Halls, Michelle L; Bunnett, Nigel W; Poole, Daniel P
信号转导
炎症
炎症/感染
发表日期：2020
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Neuroimmune Communication in Health and Disease

健康与疾病中的神经免疫通讯

期刊:Physiological Reviews
影响因子:28.7
doi:10.1152/physrev.00035.2017
Reardon, Colin; Murray, Kaitlin; Lomax, Alan E
免疫/内分泌
发表日期：2018
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