日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

PRMT5 inhibition triggers functional ATM deficiency and sensitizes pancreatic cancer to CHK1 blockade

PRMT5抑制会引发功能性ATM缺陷,并使胰腺癌对CHK1阻断剂敏感。

Dzikowski, Madeline; Pollin, Gareth; Gunia, Veda; Butler, Shawna; Enkhtuul, Byambasuren; Gavina Chavez, Jennifer; Zimmermann, Michael T; Mathison, Angela; Urrutia, Raul; Lomberk, Gwen

Mutant KRAS Heterogeneity Shapes Nuclear Architecture During Pancreatic Cancer Initiation.

突变型KRAS异质性在胰腺癌发生过程中塑造核结构。

Pollin Gareth, Mathison Angela J, Leverence Elise N, De Assuncao Thiago Milech, Iovanna Juan, Hong Johnny C, Zimmermann Michael T, Urrutia Raul, Lomberk Gwen

Targeting the Epigenetic Regulator CBX5 Promotes Fibroblast Metabolic Reprogramming and Inhibits Lung Fibrosis

靶向表观遗传调控因子CBX5可促进成纤维细胞代谢重编程并抑制肺纤维化

Hong, Jeongmin; Pham, Tho X; Lee, Jisu; Raslan, Ahmed A; Nicolas, Kristina; Sharov, Andrei; Meridew, Jeffrey A; Urrutia, Raul A; Lomberk, Gwen; Huang, Steven K; Ligresti, Giovanni

KRAS inhibition reverses chemotherapy resistance promoted by therapy-induced senescence-like in pancreatic ductal adenocarcinoma

KRAS抑制可逆转胰腺导管腺癌中由治疗诱导的衰老样细胞引起的化疗耐药性

Abuelafia, Analia Meilerman; Santofimia-Castaño, Patricia; Estaras, Matias; Grasso, Daniel; Chuluyan, Eduardo; Lomberk, Gwen; Urrutia, Raul; Dusetti, Nelson; Fraunhoffer, Nicolas; Iovanna, Juan

Genomic features of the methylosome protein MEP50 and its implications in hormone signaling and cancer

甲基化体蛋白MEP50的基因组特征及其在激素信号传导和癌症中的作用

Pollin, Gareth; Chi, Young-In; Urrutia, Raul; Lomberk, Gwen

Transcriptional drivers and endocrine disorders

转录驱动因子与内分泌紊乱

Lomberk, Gwen; Simmen, Rosalia C M

Emergent properties of the lysine methylome reveal regulatory roles via protein interactions and histone mimicry

赖氨酸甲基化组的涌现特性揭示了其通过蛋白质相互作用和组蛋白模拟发挥的调控作用

Pollin, Gareth; Chi, Young-In; Mathison, Angela J; Zimmermann, Michael T; Lomberk, Gwen; Urrutia, Raul

The triple code model for advancing research in rare and undiagnosed diseases beyond the base pairs

三重编码模型:超越碱基对,推进罕见病和未确诊疾病的研究

Lomberk, Gwen; Urrutia, Raul

Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in KrasG12D-driven tumors

靶向 NUPR1 依赖性应激颗粒形成以诱导 KrasG12D 驱动的肿瘤的合成致死

Patricia Santofimia-Castaño, Nicolas Fraunhoffer, Xi Liu, Ivan Fernandez Bessone, Marina Pasca di Magliano, Stephane Audebert, Luc Camoin, Matias Estaras, Manon Brenière, Mauro Modesti, Gwen Lomberk, Raul Urrutia, Philippe Soubeyran, Jose Luis Neira, Juan Iovanna

EZH2 deletion does not affect acinar regeneration but restricts progression to pancreatic cancer in mice.

EZH2 缺失不影响腺泡再生,但会限制小鼠胰腺癌的进展

Jaune-Pons Emilie, Wang Xiaoyi, Mousavi Fatemeh, Klassen Zachary, El Kaoutari Abdessamad, Berger Kurt, Johnson Charis, Martin Mickenzie B, Aggarwal Saloni, Brar Sukhman, Khalid Muhammad, Ryan Joanna F, Shooshtari Parisa, Mathison Angela J, Dusetti Nelson, Urrutia Raul, Lomberk Gwen, Pin Christopher L