日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

PRMT5 inhibition triggers functional ATM deficiency and sensitizes pancreatic cancer to CHK1 blockade

PRMT5抑制会引发功能性ATM缺陷，并使胰腺癌对CHK1阻断剂敏感。

期刊:Frontiers in Cell and Developmental Biology
影响因子:4.3
doi:10.3389/fcell.2026.1748541
Dzikowski, Madeline; Pollin, Gareth; Gunia, Veda; Butler, Shawna; Enkhtuul, Byambasuren; Gavina Chavez, Jennifer; Zimmermann, Michael T; Mathison, Angela; Urrutia, Raul; Lomberk, Gwen
肿瘤
肿瘤免疫
ATM
胰腺癌
CHK1
发表日期：2026
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Mutant KRAS Heterogeneity Shapes Nuclear Architecture During Pancreatic Cancer Initiation.

突变型KRAS异质性在胰腺癌发生过程中塑造核结构。

期刊:Epigenomes
影响因子:3.5
doi:10.3390/epigenomes10010019
Pollin Gareth, Mathison Angela J, Leverence Elise N, De Assuncao Thiago Milech, Iovanna Juan, Hong Johnny C, Zimmermann Michael T, Urrutia Raul, Lomberk Gwen
胰腺癌
肿瘤
RAS
发表日期：2026
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Targeting the Epigenetic Regulator CBX5 Promotes Fibroblast Metabolic Reprogramming and Inhibits Lung Fibrosis

靶向表观遗传调控因子CBX5可促进成纤维细胞代谢重编程并抑制肺纤维化

期刊:American Journal of Respiratory Cell and Molecular Biology
影响因子:5.3
doi:10.1165/rcmb.2024-0255OC
Hong, Jeongmin; Pham, Tho X; Lee, Jisu; Raslan, Ahmed A; Nicolas, Kristina; Sharov, Andrei; Meridew, Jeffrey A; Urrutia, Raul A; Lomberk, Gwen; Huang, Steven K; Ligresti, Giovanni
成纤维细胞
CBX5
表观遗传
信号转导
代谢
代谢重编程
细胞生物学
发表日期：2025
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KRAS inhibition reverses chemotherapy resistance promoted by therapy-induced senescence-like in pancreatic ductal adenocarcinoma

KRAS抑制可逆转胰腺导管腺癌中由治疗诱导的衰老样细胞引起的化疗耐药性

期刊:Translational Oncology
影响因子:4.1
doi:10.1016/j.tranon.2025.102421
Abuelafia, Analia Meilerman; Santofimia-Castaño, Patricia; Estaras, Matias; Grasso, Daniel; Chuluyan, Eduardo; Lomberk, Gwen; Urrutia, Raul; Dusetti, Nelson; Fraunhoffer, Nicolas; Iovanna, Juan
肿瘤
肿瘤免疫
衰老
细胞生物学
RAS
发表日期：2025
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Genomic features of the methylosome protein MEP50 and its implications in hormone signaling and cancer

甲基化体蛋白MEP50的基因组特征及其在激素信号传导和癌症中的作用

期刊:Endocrine Connections
影响因子:2.8
doi:10.1530/EC-25-0444
Pollin, Gareth; Chi, Young-In; Urrutia, Raul; Lomberk, Gwen
肿瘤
表观遗传
肿瘤免疫
信号转导
免疫/内分泌
发表日期：2025
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Transcriptional drivers and endocrine disorders

转录驱动因子与内分泌紊乱

期刊:Endocrine Connections
影响因子:2.8
doi:10.1530/EC-25-0688
Lomberk, Gwen; Simmen, Rosalia C M
免疫/内分泌
发表日期：2025
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Emergent properties of the lysine methylome reveal regulatory roles via protein interactions and histone mimicry

赖氨酸甲基化组的涌现特性揭示了其通过蛋白质相互作用和组蛋白模拟发挥的调控作用

期刊:Epigenomics
影响因子:2.6
doi:10.1080/17501911.2024.2435244
Pollin, Gareth; Chi, Young-In; Mathison, Angela J; Zimmermann, Michael T; Lomberk, Gwen; Urrutia, Raul
信号转导
表观遗传
发表日期：2025
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The triple code model for advancing research in rare and undiagnosed diseases beyond the base pairs

三重编码模型：超越碱基对，推进罕见病和未确诊疾病的研究

期刊:Epigenomics
影响因子:2.6
doi:10.1080/17501911.2024.2436837
Lomberk, Gwen; Urrutia, Raul
发表日期：2025
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EZH2 deletion does not affect acinar regeneration but restricts progression to pancreatic cancer in mice.

EZH2 缺失不影响腺泡再生，但会限制小鼠胰腺癌的进展

期刊:JCI Insight
影响因子:6.1
doi:10.1172/jci.insight.173746
Jaune-Pons Emilie, Wang Xiaoyi, Mousavi Fatemeh, Klassen Zachary, El Kaoutari Abdessamad, Berger Kurt, Johnson Charis, Martin Mickenzie B, Aggarwal Saloni, Brar Sukhman, Khalid Muhammad, Ryan Joanna F, Shooshtari Parisa, Mathison Angela J, Dusetti Nelson, Urrutia Raul, Lomberk Gwen, Pin Christopher L
肿瘤
胰腺癌
发表日期：2024
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Ehmt2 inactivation in pancreatic epithelial cells shapes the transcriptional landscape and inflammation response of the whole pancreas

胰腺上皮细胞中 Ehmt2 失活会影响整个胰腺的转录组图谱和炎症反应。

期刊:Frontiers in Genetics
影响因子:2.8
doi:10.3389/fgene.2024.1412767
Pollin, Gareth; Mathison, Angela J; de Assuncao, Thiago M; Thomas, Anju; Zeighami, Atefeh; Salmonson, Ann; Liu, Hongfei; Urrutia, Guillermo; Vankayala, Pallavi; Pandol, Stephen J; Hong, Johnny C; Zimmermann, Michael T; Iovanna, Juan; Jin, Victor X; Urrutia, Raul; Lomberk, Gwen
炎症/感染
细胞生物学
炎症
上皮细胞
发表日期：2024
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