日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

EGFR inhibitor-resistant lung cancers exhibit collateral sensitivity to a covalent, cysteine-independent KEAP1 oligomerizing molecular bridge.

对 EGFR 抑制剂耐药的肺癌表现出对共价、不依赖半胱氨酸的 KEAP1 寡聚化分子桥的协同敏感性。

Bassil Christopher F, Dillon Kerry, Anderson Gray R, Mayro Benjamin, Askin Kayleigh N, Winter Peter S, Harry Stefan, Gruber Samuel, Hall Tierney M, Hoj Jacob P, Cerda-Smith Christian, Hutchinson Haley M, Killarney Shane T, Heffernan Ava, Teddy Caroline, Singleton Katherine R, Qin Li, Jubien-Girard Kévin, Favreau Cécile, Robert Guillaume, Tivon Barr, Livnah Ella, London Nir, Benhida Rachid, Auberger Patrick, Pendergast Ann Marie, Bar-Peled Liron, Lonard David M, Martin Anthony R, Puissant Alexandre, Wood Kris C

Discovery of Covalent Ligands with AlphaFold3

利用 AlphaFold3 发现共价配体

Shamir, Yoav; Gabizon, Ronen; Rogel, Adi; Lin, David Yin-Wei; Andreotti, Amy H; London, Nir

Covalent Proximity Inducers

共价邻近诱导剂

London, Nir

Computational Design of Lysine Targeting Covalent Binders Using Rosetta.

利用 Rosetta 进行赖氨酸靶向共价结合剂的计算设计

Tivon Barr, Wiese Jan, Müller Matthias P, Gabizon Ronen, Rauh Daniel, London Nir

Discovery of orally bioavailable Zika and West Nile Virus antiviral compounds targeting the NS2B-NS3 protease

发现可口服生物利用的寨卡病毒和西尼罗病毒抗病毒化合物,这些化合物靶向NS2B-NS3蛋白酶

Kenton, Nathaniel T; Barr, Haim; Cherepakha, Artem; Coelmont, Lotte; Collard, Caroline; Cousins, David; Davies, Geraint H M; Degtyarenko, Oleksii; Dirksen, Andrew; Elbrecht, Daniel; Fearon, Daren; Gayvert, James; Griffen, Edward; Jochmans, Dirk; Kaptein, Suzanne; Kliatskiy, Pavlo; Kochetkov, Artem; Kordubailo, Mykyta; Lahav, Noa; London, Nir; Maas, Elke; Marples, Peter; Nady, Nataliya; Neyts, Johan; Nguyen, Luong; Ni, Xiaomin; Ogorodnik, Yuliia; Robinson, Matthew C; Simpson, Carolina Turk; Tarabara, Ihor; Tkachenko, Anton; von Delft, Annette; von Delft, Frank; Yakymenko, Oleksandr; Lee, Alpha A

Deconvoluting low yield from weak potency in direct-to-biology workflows with machine learning

利用机器学习从直接生物制剂工作流程中解析低产量和弱效力问题

McCorkindale, William; Filep, Mihajlo; London, Nir; Lee, Alpha A; King-Smith, Emma

Turning high-throughput structural biology into predictive inhibitor design

将高通量结构生物学转化为预测性抑制剂设计

Saar, Kadi L; McCorkindale, William; Fearon, Daren; Boby, Melissa; Barr, Haim; Ben-Shmuel, Amir; London, Nir; von Delft, Frank; Chodera, John D; Lee, Alpha A

Azapeptide activity-based probes for the SARS-CoV-2 main protease enable visualization of inhibition in infected cells

基于氮杂肽活性的SARS-CoV-2主蛋白酶探针能够可视化感染细胞中的抑制情况。

Vanhoutte, Roeland; Barniol-Xicota, Marta; Chiu, Winston; Vangeel, Laura; Jochmans, Dirk; De Jonghe, Steven; Zidane, Hadeer; Barr, Haim M; London, Nir; Neyts, Johan; Verhelst, Steven H L

Structure-guided design and characterization of a clickable, covalent PARP16 inhibitor

基于结构的可点击共价PARP16抑制剂的设计与表征

Bejan, Daniel S; Sundalam, Sunil; Jin, Haihong; Morgan, Rory K; Kirby, Ilsa T; Siordia, Ivan R; Tivon, Barr; London, Nir; Cohen, Michael S

Expanding the Repertoire of Low-Molecular-Weight Pentafluorosulfanyl-Substituted Scaffolds

拓展低分子量五氟硫基取代骨架的种类

Jose, Arathy; Guest, Daniel; LeGay, Remi; Tizzard, Graham J; Coles, Simon J; Derveni, Mariliza; Wright, Edward; Marrison, Lester; Lee, Alpha A; Morris, Aaron; Robinson, Matt; von Delft, Frank; Fearon, Daren; Koekemoer, Lizbé; Matviuk, Tetiana; Aimon, Anthony; Schofield, Christopher J; Malla, Tika R; London, Nir; Greenland, Barnaby W; Bagley, Mark C; Spencer, John; The Covid Moonshot Consortium