日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identifying ligands for the PHD1 finger of KDM5A through high-throughput screening

通过高通量筛选鉴定KDM5A的PHD1指状结构域的配体

Ortiz, Gloria; Longbotham, James E; Qin, Sophia L; Zhang, Meng Yao; Lee, Gregory M; Neitz, R Jeffrey; Kelly, Mark J S; Arkin, Michelle R; Fujimori, Danica Galonić

Recognition of Histone H3 Methylation States by the PHD1 Domain of Histone Demethylase KDM5A

组蛋白去甲基化酶KDM5A的PHD1结构域对组蛋白H3甲基化状态的识别

Longbotham, James E; Kelly, Mark J S; Fujimori, Danica Galonić

Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2

病毒 E 蛋白可中和 BET 蛋白介导的 SARS-CoV-2 进入后拮抗作用

Irene P Chen, James E Longbotham, Sarah McMahon, Rahul K Suryawanshi, Mir M Khalid, Taha Y Taha, Takako Tabata, Jennifer M Hayashi, Frank W Soveg, Jared Carlson-Stevermer, Meghna Gupta, Meng Yao Zhang, Victor L Lam, Yang Li, Zanlin Yu, Erron W Titus, Amy Diallo, Jennifer Oki, Kevin Holden, Nevan Kro

Exploring the Ligand Preferences of the PHD1 Domain of Histone Demethylase KDM5A Reveals Tolerance for Modifications of the Q5 Residue of Histone 3

探索组蛋白去甲基化酶KDM5A的PHD1结构域的配体偏好性揭示了其对组蛋白3的Q5残基修饰的耐受性

Anderson, Sarah E; Longbotham, James E; O'Kane, Patrick T; Ugur, Fatima S; Fujimori, Danica Galonić; Mrksich, Milan

Dissecting contributions of catalytic and reader domains in regulation of histone demethylation

剖析催化结构域和读取结构域在组蛋白去甲基化调控中的作用

Petronikolou, Nektaria; Longbotham, James E; Fujimori, Danica Galonić

Convergence of theory and experiment on the role of preorganization, quantum tunneling and enzyme motions into flavoenzyme-catalyzed hydride transfer

理论与实验在预组织、量子隧穿和酶运动在黄素酶催化氢化物转移中的作用方面趋于一致

Delgado, Manuel; Görlich, Stefan; Longbotham, James E; Scrutton, Nigel S; Hay, Sam; Moliner, Vicent; Tuñón, Iñaki