日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Small molecule modulation of the p75 neurotrophin receptor promotes dendritic spine resilience to pathogenic tau species and reduces their accumulation

小分子调控p75神经营养因子受体可增强树突棘对致病性tau蛋白的抵抗力并减少其积累。

Yang, Tao; Ay, Yeonglong; Kaur, Sukhneet; Butler, Robert R 3rd; Tran, Kevin C; Liu, Harry; Langness, Vanessa F; Massa, Stephen M; Longo, Frank M

p75NTR modulation prevents cellular, cortical activity and cognitive dysfunctions caused by perinatal hypoxia.

p75NTR 调节可预防围产期缺氧引起的细胞、皮层活动和认知功能障碍

Chattopadhyaya Bidisha, Lee Karen K Y, Carreño-Muñoz Maria Isabel, Paris-Rubianes Andrea, Lavertu-Jolin Marisol, Berryer Martin H, Longo Frank M, Di Cristo Graziella

Plasma Aβ(42)/Aβ(40) is sensitive to early cerebral amyloid accumulation and predicts risk of cognitive decline across the Alzheimer's disease spectrum

血浆Aβ(42)/Aβ(40)比值对早期脑淀粉样蛋白沉积敏感,并可预测阿尔茨海默病谱系中认知功能下降的风险。

Trelle, Alexandra N; Young, Christina B; Vossler, Hillary; Ramos Benitez, Javier; Cody, Karly A; Mendiola, Justin H; Swarovski, Michelle S; Guen, Yann Le; Feinstein, Igor; Butler, Robert R 3rd; Channappa, Divya; Romero, America; Park, Jennifer; Shahid-Besanti, Marian; Corso, Nicole K; Chau, Kelly; Smith, Amanda N; Skylar-Scott, Irina; Yutsis, Maya V; Fredericks, Carolyn A; Tian, Lu; Younes, Kyan; Kerchner, Geoffrey A; Deutsch, Gayle K; Davidzon, Guido A; Sha, Sharon J; Henderson, Victor W; Longo, Frank M; Greicius, Michael D; Wyss-Coray, Tony; Andreasson, Katrin I; Poston, Kathleen L; Wagner, Anthony D; Mormino, Elizabeth C; Wilson, Edward N

Parkinson's disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction.

帕金森病的特征是维生素 B6 依赖性炎症犬尿氨酸通路功能障碍

Wilson Edward N, Umans Jacob, Swarovski Michelle S, Minhas Paras S, Mendiola Justin H, Midttun Øivind, Ulvik Arve, Shahid-Besanti Marian, Linortner Patricia, Mhatre Siddhita D, Wang Qian, Channappa Divya, Corso Nicole K, Tian Lu, Fredericks Carolyn A, Kerchner Geoffrey A, Plowey Edward D, Cholerton Brenna, Ueland Per M, Zabetian Cyrus P, Gray Nora E, Quinn Joseph F, Montine Thomas J, Sha Sharon J, Longo Frank M, Wolk David A, Chen-Plotkin Alice, Henderson Victor W, Wyss-Coray Tony, Wagner Anthony D, Mormino Elizabeth C, Aghaeepour Nima, Poston Kathleen L, Andreasson Katrin I

Small molecule modulation of p75(NTR) engages the autophagy-lysosomal pathway and reduces huntingtin aggregates in cellular and mouse models of Huntington's disease.

小分子调节 p75(NTR) 可激活自噬-溶酶体途径,并减少亨廷顿病细胞和小鼠模型中的亨廷顿蛋白聚集体

Simmons Danielle A, Alexander Namitha, Cao Gloria, Rippin Ido, Lugassy Yarine, Eldar-Finkelman Hagit, Longo Frank M

A Small-Molecule TrkB/TrkC Ligand Promotes Neurogenesis and Behavioral Recovery Following Traumatic Brain Injury.

小分子TrkB/TrkC配体促进创伤性脑损伤后的神经发生和行为恢复

Shi Jian, Yang Tao, Li Yibing, Zhong Lily, Longo Frank M, Massa Stephen M

Mapping cross-domain drivers of Alzheimer's disease risk through integrated network analysis

通过整合网络分析绘制阿尔茨海默病风险的跨领域驱动因素图谱

Cary, Gregory A; Keegan, Stephen; Wiley, Jesse C; Gockley, Jake; Longo, Frank M; Levey, Allan I; Greenwood, Anna K; Leal, Karina; Carter, Gregory W

Uncovering Heterogeneous Effects via Localized Feature Selection

通过局部特征选择揭示异质效应

Liu, Xiaoxia; Gu, Jiaqi; Chen, Zhaomeng; Chu, Benjamin; Liu, Linxi; Morrison, Tim; Butler, Robert R 3rd; Edelson, Jacob; Li, Jinzhou; Longo, Frank M; Tang, Hua; Ionita-Laza, Iuliana; Sabatti, Chiara; Candès, Emmanuel; He, Zihuai

Twenty years of therapeutic development in tauopathy mouse models: a scoping review

二十年来tau蛋白病小鼠模型治疗进展:一项范围综述

Langness, Vanessa F; Simmons, Danielle A; McHugh, Tyne L M; Butler, Robert R 3rd; Zhou, James; Liu, Harry; Yang, Tao; Ellerby, Lisa M; Longo, Frank M

Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies

恢复海马葡萄糖代谢可以改善阿尔茨海默病病理状态下的认知功能

Minhas, Paras S; Jones, Jeffrey R; Latif-Hernandez, Amira; Sugiura, Yuki; Durairaj, Aarooran S; Wang, Qian; Mhatre, Siddhita D; Uenaka, Takeshi; Crapser, Joshua; Conley, Travis; Ennerfelt, Hannah; Jung, Yoo Jin; Liu, Ling; Prasad, Praveena; Jenkins, Brenita C; Ay, Yeonglong Albert; Matrongolo, Matthew; Goodman, Ryan; Newmeyer, Traci; Heard, Kelly; Kang, Austin; Wilson, Edward N; Yang, Tao; Ullian, Erik M; Serrano, Geidy E; Beach, Thomas G; Wernig, Marius; Rabinowitz, Joshua D; Suematsu, Makoto; Longo, Frank M; McReynolds, Melanie R; Gage, Fred H; Andreasson, Katrin I