日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Immunogenicity and efficacy of an mRNA vaccine expressing a virus-like particle spike antigen against SARS-CoV-2

表达病毒样颗粒刺突抗原的mRNA疫苗对SARS-CoV-2的免疫原性和有效性

Laliberte, Jason P; Cai, Yingyun; Kenny, Tara; Zhang, Yi; Ren, Kuishu; Rosenthal, Kim; Flores, Daniel; Roque, Richard; Acton, Oliver; Peano, Vanessa Cadevilla; Janney, Noel; Puri, Vinita; Siddiqui, Sarah; Pack, Angela; Padilla, Giune; Diallo, Seme; Adissu, Hibret; Choudhary, Rakesh; Pruitt, Hawley; Cheng, Yi-Han; Thom, George; Newton, Michael; Kurokawa, Cheyne; Guest, Johnathan; Swanson, Phillip; Loo, Yueh-Ming; Francica, Joseph R; Blair, Wade; Esser, Mark

A multilocus perspective on the evolutionary dynamics of multistrain pathogens

多位点视角下的多菌株病原体进化动力学

Loo, Yueh-Ming; Gale, Michael Jr; McLeod, David V; Bank, Claudia; Gandon, Sylvain

Antibody targeting of conserved sites of vulnerability on the SARS-CoV-2 spike receptor-binding domain.

针对SARS-CoV-2刺突蛋白受体结合域上保守易感位点的抗体

Sankhala Rajeshwer S, Dussupt Vincent, Chen Wei-Hung, Bai Hongjun, Martinez Elizabeth J, Jensen Jaime L, Rees Phyllis A, Hajduczki Agnes, Chang William C, Choe Misook, Yan Lianying, Sterling Spencer L, Swafford Isabella, Kuklis Caitlin, Soman Sandrine, King Jocelyn, Corbitt Courtney, Zemil Michelle, Peterson Caroline E, Mendez-Rivera Letzibeth, Townsley Samantha M, Donofrio Gina C, Lal Kerri G, Tran Ursula, Green Ethan C, Smith Clayton, de Val Natalia, Laing Eric D, Broder Christopher C, Currier Jeffrey R, Gromowski Gregory D, Wieczorek Lindsay, Rolland Morgane, Paquin-Proulx Dominic, van Dyk Dewald, Britton Zachary, Rajan Saravanan, Loo Yueh Ming, McTamney Patrick M, Esser Mark T, Polonis Victoria R, Michael Nelson L, Krebs Shelly J, Modjarrad Kayvon, Joyce M Gordon

The SARS-CoV-2 monoclonal antibody combination, AZD7442, is protective in nonhuman primates and has an extended half-life in humans

SARS-CoV-2单克隆抗体组合AZD7442在非人灵长类动物中具有保护作用,并且在人体内具有较长的半衰期。

Loo, Yueh-Ming; McTamney, Patrick M; Arends, Rosalinda H; Abram, Michael E; Aksyuk, Anastasia A; Diallo, Seme; Flores, Daniel J; Kelly, Elizabeth J; Ren, Kuishu; Roque, Richard; Rosenthal, Kim; Streicher, Katie; Tuffy, Kevin M; Bond, Nicholas J; Cornwell, Owen; Bouquet, Jerome; Cheng, Lily I; Dunyak, James; Huang, Yue; Rosenbaum, Anton I; Pilla Reddy, Venkatesh; Andersen, Hanne; Carnahan, Robert H; Crowe, James E Jr; Kuehne, Ana I; Herbert, Andrew S; Dye, John M; Bright, Helen; Kallewaard, Nicole L; Pangalos, Menelas N; Esser, Mark T

1143. Prophylactic and Therapeutic Activity of AZD7442 (Tixagevimab/Cilgavimab) in SARS-CoV-2 Hamster Challenge Models

1143. AZD7442(Tixagevimab/Cilgavimab)在SARS-CoV-2仓鼠感染模型中的预防和治疗活性

Evans, M J; Keeling, J W; Loo, Yueh-Ming; Herbert, Andrew S; Kuehne, Ana I; McTamney, Patrick M; Roque, Richard; Moreau, Alicia M; Bakken, Russell; Stefan, Christopher P; Koehler, Jeffrey W; Delp, Korey L; Coyne, Susan R; Kane, Christopher D; Dye, John M; Cai, Yingyun; Esser, Mark T

Potently neutralizing human antibodies that block SARS-CoV-2 receptor binding and protect animals

能有效中和SARS-CoV-2病毒受体结合并保护动物的人类抗体

Zost, Seth J; Gilchuk, Pavlo; Case, James Brett; Binshtein, Elad; Chen, Rita E; Reidy, Joseph X; Trivette, Andrew; Nargi, Rachel S; Sutton, Rachel E; Suryadevara, Naveenchandra; Williamson, Lauren E; Chen, Elaine C; Jones, Taylor; Day, Samuel; Myers, Luke; Hassan, Ahmed O; Kafai, Natasha M; Winkler, Emma S; Fox, Julie M; Steinhardt, James J; Ren, Kuishu; Loo, Yueh-Ming; Kallewaard, Nicole L; Martinez, David R; Schäfer, Alexandra; Gralinski, Lisa E; Baric, Ralph S; Thackray, Larissa B; Diamond, Michael S; Carnahan, Robert H; Crowe, James E

A small-molecule IRF3 agonist functions as an influenza vaccine adjuvant by modulating the antiviral immune response

一种小分子IRF3激动剂通过调节抗病毒免疫反应发挥流感疫苗佐剂的作用。

Probst, Peter; Grigg, John B; Wang, Myra; Muñoz, Ernesto; Loo, Yueh-Ming; Ireton, Renee C; Gale, Michael Jr; Iadonato, Shawn P; Bedard, Kristin M

Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6.

组蛋白去乙酰化酶 6 对视黄酸诱导基因-I (RIG-I) 激活的调控

Liu Helene Minyi, Jiang Fuguo, Loo Yueh Ming, Hsu ShuZhen, Hsiang Tien-Ying, Marcotrigiano Joseph, Gale Michael Jr

Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway

利用RLR通路小分子激动剂靶向先天免疫进行抗病毒治疗

Pattabhi, Sowmya; Wilkins, Courtney R; Dong, Ran; Knoll, Megan L; Posakony, Jeffrey; Kaiser, Shari; Mire, Chad E; Wang, Myra L; Ireton, Renee C; Geisbert, Thomas W; Bedard, Kristin M; Iadonato, Shawn P; Loo, Yueh-Ming; Gale, Michael Jr

Membrane Perturbation-Associated Ca2+ Signaling and Incoming Genome Sensing Are Required for the Host Response to Low-Level Enveloped Virus Particle Entry

膜扰动相关的Ca2+信号传导和进入的基因组感知是宿主对低水平包膜病毒颗粒入侵做出反应所必需的

Hare, David N; Collins, Susan E; Mukherjee, Subhendu; Loo, Yueh-Ming; Gale, Michael Jr; Janssen, Luke J; Mossman, Karen L