日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway.

APOE3 基因中的 R136S 突变通过抑制 cGAS-STING-IFN 通路赋予机体抵抗 tau 病理的能力

Naguib Sarah, Lopez-Lee Chloe, Torres Eileen Ruth, Lee Se-In, Zhu Jingjie, Zhu Daphne, Ye Pearly, Norman Kendra, Zhao Mingrui, Wong Man Ying, Ambaw Yohannes A, Muñoz-Castañeda Rodrigo, Wang Wei, Patel Tark, Bhagwat Maitreyee, Norinsky Rada, Mok Sue-Ann, Walther Tobias C, Farese Robert V Jr, Luo Wenjie, Sinha Subhash C, Wu Zhuhao, Fan Li, Gong Shiaoching, Gan Li

Tlr7 drives sex differences in age- and Alzheimer's disease-related demyelination.

Tlr7 驱动与年龄和阿尔茨海默病相关的脱髓鞘的性别差异

Lopez-Lee Chloe, Kodama Lay, Fan Li, Zhu Daphne, Zhu Jingjie, Wong Man Ying, Ye Pearly, Norman Kendra, Foxe Nessa R, Ijaz Laraib, Yu Fangmin, Chen Hao, Carling Gillian K, Torres Eileen R, Kim Rachel D, Dubal Dena B, Liddelow Shane A, Sinha Subhash C, Luo Wenjie, Gan Li

Mechanisms of sex differences in Alzheimer's disease

阿尔茨海默病性别差异的机制

Lopez-Lee, Chloe; Torres, Eileen Ruth S; Carling, Gillian; Gan, Li

Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model.

阿尔茨海默病相关风险等位基因在 tau 蛋白病模型中加剧小胶质细胞 cGAS 相关的衰老和神经退行性变

Carling Gillian K, Fan Li, Foxe Nessa R, Norman Kendra, Wong Man Ying, Zhu Daphne, Corona Carlo, Razzoli Agnese, Yu Fangmin, Yarahmady Allan, Ye Pearly, Chen Hao, Huang Yige, Amin Sadaf, Sereda Rebecca, Lopez-Lee Chloe, Zacharioudakis Emmanouil, Chen Xiaoying, Xu Jielin, Cheng Feixiong, Gavathiotis Evripidis, Cuervo Ana Maria, Holtzman David M, Mok Sue-Ann, Sinha Subhash C, Sidoli Simone, Ratan Rajiv R, Luo Wenjie, Gong Shiaoching, Gan Li

DAP12 deficiency alters microglia-oligodendrocyte communication and enhances resilience against tau toxicity

DAP12 缺乏会改变小胶质细胞-少突胶质细胞之间的通讯,并增强对 tau 蛋白毒性的抵抗力。

Chen, Hao; Fan, Li; Guo, Qi; Wong, Man Ying; Yu, Fangmin; Foxe, Nessa; Wang, Winston; Nessim, Aviram; Carling, Gillian; Liu, Bangyan; Lopez-Lee, Chloe; Huang, Yige; Amin, Sadaf; Patel, Tark; Mok, Sue-Ann; Song, Won-Min; Zhang, Bin; Ma, Qin; Fu, Hongjun; Gan, Li; Luo, Wenjie

Sex Differences in Neurodegeneration: The Role of the Immune System in Humans

神经退行性疾病中的性别差异:免疫系统在人类中的作用

Lopez-Lee, Chloe; Kodama, Lay; Gan, Li