日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2

CACHE挑战赛#3:靶向SARS-CoV-2的Nsp3宏结构域

Herasymenko, Oleksandra; Silva, Madhushika; Correy, Galen J; Abu-Saleh, Abd Al-Aziz A; Ackloo, Suzanne; Arrowsmith, Cheryl; Ashworth, Alan; Ban, Fuqiang; Beck, Hartmut; Bishop, Kevin P; Bohórquez, Hugo J; Bolotokova, Albina; Breznik, Marko; Chau, Irene; Chen, Yu; Cherkasov, Artem; Dehaen, Wim; Della Corte, Dennis; Denzinger, Katrin; Doering, Niklas P; Edfeldt, Kristina; Edwards, Aled; Fayne, Darren; Gentile, Francesco; Gibson, Elisa; Gokdemir, Ozan; Gunnarsson, Anders; Günther, Judith; Irwin, John J; Jensen, Jan Halborg; Harding, Rachel J; Hillisch, Alexander; Hoffer, Laurent; Hogner, Anders; Hutchinson, Ashley; Kandwal, Shubhangi; Karlova, Andrea; Koirala, Kushal; Kotelnikov, Sergei; Kozakov, Dima; Lee, Juyong; Lee, Soowon; Lessel, Uta; Liu, Sijie; Liu, Xuefeng; Loppnau, Peter; Meiler, Jens; Moretti, Rocco; Moroz, Yurii S; Muvva, Charuvaka; Oprea, Tudor I; Paige, Brooks; Pandit, Amit; Park, Keunwan; Poda, Gennady; Protopopov, Mykola V; Pütter, Vera; Ravichandran, Rahul; Rognan, Didier; Rosta, Edina; Sabnis, Yogesh; Scott, Thomas; Seitova, Almagul; Sharma, Purshotam; Sindt, François; Song, Minghu; Steinmann, Casper; Stevens, Rick; Talagayev, Valerij; Tararina, Valentyna V; Tarkhanova, Olga; Tingey, Damon; Trant, John F; Treleaven, Dakota; Tropsha, Alexander; Walters, Patrick; Wells, Jude; Westermaier, Yvonne; Wolber, Gerhard; Wortmann, Lars; Zheng, Shuangjia; Fraser, James S; Schapira, Matthieu

A BRET biosensor for measuring uncompetitive engagement of PRMT5 complexes in cells.

一种用于测量细胞中 PRMT5 复合物非竞争性结合的 BRET 生物传感器。

Rothweiler Elisabeth M, Michaud Ani, Stefaniak Jakub, Singh Usha, Mikulsky Brynwood B, Vasta James D, Beck Michael T, Wilkinson Jennifer, Ward Jennifer A, Rogers Catherine M, Balıkçı Esra, Tranberg-Jensen Jeppe, Hansen Jesper S, Loppnau Peter, Whitty Adrian, Brennan Paul E, Tonge Peter J, Robers Matthew B, Huber Kilian V M

A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins

WD40重复序列蛋白的靶向配体结合能力评价

Ackloo, Suzanne; Li, Fengling; Szewczyk, Magda; Seitova, Almagul; Loppnau, Peter; Zeng, Hong; Xu, Jin; Ahmad, Shabbir; Arnautova, Yelena A; Baghaie, A J; Beldar, Serap; Bolotokova, Albina; Centrella, Paolo A; Chau, Irene; Clark, Matthew A; Cuozzo, John W; Dehghani-Tafti, Saba; Disch, Jeremy S; Dong, Aiping; Dumas, Antoine; Feng, Jianwen A; Ghiabi, Pegah; Gibson, Elisa; Gilmer, Justin; Goldman, Brian; Green, Stuart R; Guié, Marie-Aude; Guilinger, John P; Harms, Nathan; Herasymenko, Oleksandra; Houliston, Scott; Hutchinson, Ashley; Kearnes, Steven; Keefe, Anthony D; Kimani, Serah W; Kramer, Trevor; Kutera, Maria; Kwak, Haejin A; Lento, Cristina; Li, Yanjun; Liu, Jenny; Loup, Joachim; Machado, Raquel A C; Mulhern, Christopher J; Perveen, Sumera; Righetto, Germanna L; Riley, Patrick; Shrestha, Suman; Sigel, Eric A; Silva, Madhushika; Sintchak, Michael D; Slakman, Belinda L; Taylor, Rhys D; Thompson, James; Torng, Wen; Underkoffler, Carl; von Rechenberg, Moritz; Walsh, Ryan T; Watson, Ian; Wilson, Derek J; Wolf, Esther; Yadav, Manisha; Yazdi, Aliakbar K; Zhang, Junyi; Zhang, Ying; Santhakumar, Vijayaratnam; Edwards, Aled M; Barsyte-Lovejoy, Dalia; Schapira, Matthieu; Brown, Peter J; Halabelian, Levon; Arrowsmith, Cheryl H

Identification of Direct-Acting nsP2 Helicase Inhibitors with Antialphaviral Activity

鉴定具有抗甲病毒活性的直接作用nsP2解旋酶抑制剂

Muthu Ramalingam, Bose; Sears, John D; Talbot, Kacey M; Su, Yuan-Wei Norman; Houliston, Scott; Hossain, Mohammed Anwar; Davis-Gilbert, Zachary W; Zhao, Chunqing; Oh, Hans J; Brown, Peter J; Sanders, Marcia K; Moorman, Stella R; Ojha, Durbadal; Burdick, Jane E; Law, Isabella; Morales, Noah L; Martinez, Sabian A; Loppnau, Peter; Garcia Perez, Julia; Drobish, Adam M; Morrison, Thomas E; Streblow, Zachary J; Streblow, Daniel N; Arrowsmith, Cheryl H; Vargason, Ava; Couñago, Rafael M; Halabelian, Levon; Arnold, Jamie J; Cameron, Craig E; Moorman, Nathaniel J; Heise, Mark T; Willson, Timothy M

CACHE Challenge #2: Targeting the RNA Site of the SARS-CoV-2 Helicase Nsp13

CACHE挑战#2:靶向SARS-CoV-2解旋酶Nsp13的RNA位点

Herasymenko, Oleksandra; Silva, Madhushika; Abu-Saleh, Abd Al-Aziz A; Ahmad, Ayaz; Alvarado-Huayhuaz, Jesus; Arce, Oscar E A; Armstrong, Roly J; Arrowsmith, Cheryl; Bachta, Kelly E; Beck, Hartmut; Berta, Denes; Bieniek, Mateusz K; Blay, Vincent; Bolotokova, Albina; Bourne, Philip E; Breznik, Marko; Brown, Peter J; Campbell, Aaron D G; Carosati, Emanuele; Chau, Irene; Cole, Daniel J; Cree, Ben; Dehaen, Wim; Denzinger, Katrin; Dos Santos Machado, Karina; Dunn, Ian; Durai, Prasannavenkatesh; Edfeldt, Kristina; Edwards, Aled; Fayne, Darren; Felfoldi, Daniel; Friston, Kallie; Ghiabi, Pegah; Gibson, Elisa; Günther, Judith; Gunnarsson, Anders; Hillisch, Alexander; Houston, Douglas R; Jensen, Jan Halborg; Harding, Rachel J; Harris, Kate S; Hoffer, Laurent; Hogner, Anders; Horton, Joshua T; Houliston, Scott; Hultquist, Judd F; Hutchinson, Ashley; Irwin, John J; Jukič, Marko; Kandwal, Shubhangi; Karlova, Andrea; Katis, Vittorio L; Kich, Ryan P; Kireev, Dmitri; Koes, David; Inniss, Nicole L; Lessel, Uta; Liu, Sijie; Loppnau, Peter; Lu, Wei; Martino, Sam; McGibbon, Miles; Meiler, Jens; Mettu, Akhila; Money-Kyrle, Sam; Moretti, Rocco; Moroz, Yurii S; Muvva, Charuvaka; Newman, Joseph A; Obendorf, Leon; Paige, Brooks; Pandit, Amit; Park, Keunwan; Perveen, Sumera; Pirie, Rachael; Poda, Gennady; Protopopov, Mykola; Pütter, Vera; Ricci, Federico; Roper, Natalie J; Rosta, Edina; Rzhetskaya, Margarita; Sabnis, Yogesh; Satchell, Karla J F; Schmitt Kremer, Frederico; Scott, Thomas; Seitova, Almagul; Steinmann, Casper; Talagayev, Valerij; Tarkhanova, Olga O; Tatum, Natalie J; Treleaven, Dakota; Velasque Werhli, Adriano; Walters, W Patrick; Wang, Xiaowen; Wells, Jude; Wells, Geoffrey; Westermaier, Yvonne; Wolber, Gerhard; Wortmann, Lars; Zhang, Jixian; Zhao, Zheng; Zheng, Shuangjia; Schapira, Matthieu

OICR-41103 as a chemical probe for the DCAF1 WD40 domain.

OICR-41103 作为 DCAF1 WD40 结构域的化学探针

Kimani Serah W, Noureldin Mahmoud, Wilson Brian, Hoffer Laurent, Green Stuart R, Szewczyk Magdalena M, González-Álvarez Héctor, Mohammed Mohammed, Chan Manuel, Krausser Chiara, Li Alice Shi Ming, Hajian Taraneh, Tucker Sarah, Joshi Dhananjay, Saraon Punit, Thériault Brigitte, Kim Ji Sup, Santhakumar Vijayaratnam, Loppnau Peter, Li Yanjun, Seitova Almagul, Dong Aiping, Kiyota Taira, Hammann Tobias, Gehrtz Paul, Patel Bhashant, Rathod Vaibhavi, Vala Anand, Rout Bhimsen, Jagodra Paras, Brown Peter J, Aman Ahmed, Ramnauth Jailall, Poda Gennady, Uehling David, Arrowsmith Cheryl H, Barsyte-Lovejoy Dalia, Marcellus Richard, Ackloo Suzanne, Mamai Ahmed, Al-Awar Rima, Halabelian Levon

Structure-based discovery of inhibitors of Mac1 domain of nonstructural protein-3 of SARS-CoV-2 by machine learning-augmented screening of chemical space

基于结构的SARS-CoV-2非结构蛋白3 Mac1结构域抑制剂的发现:机器学习增强化学空间筛选

Ban, Fuqiang; Ravichandran, Rahul; Correy, Galen J; Herasymenko, Oleksandra; Silva, Madhushika; Ackloo, Suzanne; Bolotokova, Albina; Chau, Irene; Gibson, Elisa; Harding, Rachel; Hutchinson, Ashley; Loppnau, Peter; Fraser, James S; Schapira, Matthieu; Cherkasov, Artem; Gentile, Francesco

Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern

表位特异性抗体反应可区分 COVID-19 的不同预后和值得关注的变异株。

Voss, Courtney; Esmail, Sally; Liu, Xuguang; Knauer, Michael J; Ackloo, Suzanne; Kaneko, Tomonori; Lowes, Lori; Stogios, Peter; Seitova, Almagul; Hutchinson, Ashley; Yusifov, Farhad; Skarina, Tatiana; Evdokimova, Elena; Loppnau, Peter; Ghiabi, Pegah; Haijan, Taraneh; Zhong, Shanshan; Abdoh, Husam; Hedley, Benjamin D; Bhayana, Vipin; Martin, Claudio M; Slessarev, Marat; Chin-Yee, Benjamin; Fraser, Douglas D; Chin-Yee, Ian; Li, Shawn Sc

A High-Throughput RNA Displacement Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex toward Developing Therapeutics for COVID-19

用于筛选SARS-CoV-2 nsp10-nsp16复合物以开发COVID-19治疗方法的高通量RNA置换分析

Perveen, Sumera; Khalili Yazdi, Aliakbar; Devkota, Kanchan; Li, Fengling; Ghiabi, Pegah; Hajian, Taraneh; Loppnau, Peter; Bolotokova, Albina; Vedadi, Masoud

Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis

对 DOT1L-AF10 复合物的结构和功能分析揭示了 MLL-AF10 相关白血病发生的机制。

Zhang, Heng; Zhou, Bo; Qin, Su; Xu, Jing; Harding, Rachel; Tempel, Wolfram; Nayak, Vinod; Li, Yanjun; Loppnau, Peter; Dou, Yali; Min, Jinrong