日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies

对WD重复结构域5抑制剂的扩展分析揭示了治疗血液系统恶性肿瘤的可行策略

Meyer, Christian T; Smith, Brianna N; Wang, Jing; Teuscher, Kevin B; Grieb, Brian C; Howard, Gregory C; Silver, Alexander J; Lorey, Shelly L; Stott, Gordon M; Moore, William J; Lee, Taekyu; Savona, Michael R; Weissmiller, April M; Liu, Qi; Quaranta, Vito; Fesik, Stephen W; Tansey, William P

Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models

基于结构的高效WD重复结构域5抑制剂的发现,在临床前动物模型中证实了其疗效和安全性。

Teuscher, Kevin B; Chowdhury, Somenath; Meyers, Kenneth M; Tian, Jianhua; Sai, Jiqing; Van Meveren, Mayme; South, Taylor M; Sensintaffar, John L; Rietz, Tyson A; Goswami, Soumita; Wang, Jing; Grieb, Brian C; Lorey, Shelly L; Howard, Gregory C; Liu, Qi; Moore, William J; Stott, Gordon M; Tansey, William P; Lee, Taekyu; Fesik, Stephen W

Clonal expansion and TCR-independent differentiation shape the HIV-specific CD8+ effector-memory T-cell repertoire in vivo.

克隆扩增和 TCR 非依赖性分化塑造了体内 HIV 特异性 CD8+ 效应记忆 T 细胞库

Meyer-Olson Dirk, Simons Brenna C, Conrad Joseph A, Smith Rita M, Barnett Louise, Lorey Shelly L, Duncan Coley B, Ramalingam Ramesh, Kalams Spyros A

Enhancement of human immunodeficiency virus (HIV)-specific CD8+ T cells in cerebrospinal fluid compared to those in blood among antiretroviral therapy-naive HIV-positive subjects.

与未接受抗逆转录病毒治疗的 HIV 阳性受试者的血液相比,脑脊液中人类免疫缺陷病毒 (HIV) 特异性 CD8+ T 细胞有所增强

Sadagopal Shanmugalakshmi, Lorey Shelly L, Barnett Louise, Basham Rebecca, Lebo Laurie, Erdem Husamettin, Haman Kirsten, Avison Malcolm, Waddell Kevin, Haas David W, Kalams Spyros A