日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis

利用选择性、可穿透血脑屏障的拮抗剂靶向毒蕈碱M1受体,以促进多发性硬化症的髓鞘再生

Poon, Michael M; Lorrain, Kym I; Stebbins, Karin J; Edu, Geraldine C; Broadhead, Alexander R; Lorenzana, Ariana J; Roppe, Jeffrey R; Baccei, Jill M; Baccei, Christopher S; Chen, Austin C; Green, Ari J; Lorrain, Daniel S; Chan, Jonah R

Discovery of a brain penetrant small molecule antagonist targeting LPA1 receptors to reduce neuroinflammation and promote remyelination in multiple sclerosis.

发现一种可穿透血脑屏障的小分子拮抗剂,靶向 LPA1 受体,以减少多发性硬化症中的神经炎症并促进髓鞘再生

Poon Michael M, Lorrain Kym I, Stebbins Karin J, Edu Geraldine C, Broadhead Alexander R, Lorenzana Ariana O, Paulson Bryanna E, Baccei Christopher S, Roppe Jeffrey R, Schrader Thomas O, Valdez Lino J, Xiong Yifeng, Chen Austin C, Lorrain Daniel S