日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Cryo-EM of Aβ fibrils from mouse models find tg-APPArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease

对小鼠模型中的 Aβ 原纤维进行冷冻电镜观察发现,tg-APPArcSwe 原纤维与散发性阿尔茨海默病患者体内发现的原纤维相似

Mara Zielinski #, Fernanda S Peralta Reyes #, Lothar Gremer, Sarah Schemmert, Benedikt Frieg, Luisa U Schäfer, Antje Willuweit, Lili Donner, Margitta Elvers, Lars N G Nilsson, Stina Syvänen, Dag Sehlin, Martin Ingelsson, Dieter Willbold, Gunnar F Schröder

Amyloid fibril formation kinetics of low-pH denatured bovine PI3K-SH3 monitored by three different NMR techniques

通过三种不同的 NMR 技术监测低 pH 变性牛 PI3K-SH3 的淀粉样蛋白原纤维形成动力学

Luis Gardon #, Nina Becker #, Nick Rähse, Christoph Hölbling, Athina Apostolidis, Celina M Schulz, Kevin Bochinsky, Lothar Gremer, Henrike Heise, Nils-Alexander Lakomek

Structural basis for the inhibition of IAPP fibril formation by the co-chaperonin prefoldin

辅助伴侣蛋白前折叠素抑制 IAPP 原纤维形成的结构基础

Ricarda Törner #, Tatsiana Kupreichyk #, Lothar Gremer, Elisa Colas Debled, Daphna Fenel, Sarah Schemmert, Pierre Gans, Dieter Willbold, Guy Schoehn, Wolfgang Hoyer, Jerome Boisbouvier

CDC42-IQGAP Interactions Scrutinized: New Insights into the Binding Properties of the GAP-Related Domain

深入研究 CDC42-IQGAP 相互作用:对 GAP 相关结构域结合特性的新见解

Niloufar Mosaddeghzadeh, Silke Pudewell, Farhad Bazgir, Neda S Kazemein Jasemi, Oliver H F Krumbach, Lothar Gremer, Dieter Willbold, Radovan Dvorsky, Mohammad R Ahmadian

Structural details of amyloid β oligomers in complex with human prion protein as revealed by solid-state MAS NMR spectroscopy

固态 MAS NMR 光谱揭示淀粉样蛋白 β 寡聚体与人类朊病毒蛋白复合物的结构细节

Anna S König, Nadine S Rösener, Lothar Gremer, Markus Tusche, Daniel Flender, Elke Reinartz, Wolfgang Hoyer, Philipp Neudecker, Dieter Willbold, Henrike Heise

Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction

小鼠 IL-12/IL-23 p40 37 位的色氨酸 (W) 是与 IL-12Rβ1 结合并随后进行信号转导所必需的

Jacqueline Georgy, Yvonne Arlt, Jens M Moll, Meryem Ouzin, Hendrik T Weitz, Lothar Gremer, Dieter Willbold, Joachim Grötzinger, Felix Thives-Kurenbach, Jürgen Scheller, Doreen M Floss

Reelin Amplifies Glycoprotein VI Activation and AlphaIIb Beta3 Integrin Outside-In Signaling via PLC Gamma 2 and Rho GTPases

Reelin 通过 PLC Gamma 2 和 Rho GTPases 放大糖蛋白 VI 活化和 AlphaIIb Beta3 整合素由外而内信号传导

Irena Krueger, Lothar Gremer, Lena Mangels, Meike Klier, Kerstin Jurk, Dieter Willbold, Hans H Bock, Margitta Elvers

Clustering of human prion protein and α-synuclein oligomers requires the prion protein N-terminus

人类朊病毒蛋白和 α-突触核蛋白寡聚体的聚集需要朊病毒蛋白 N 端

Nadine S Rösener, Lothar Gremer, Michael M Wördehoff, Tatsiana Kupreichyk, Manuel Etzkorn, Philipp Neudecker, Wolfgang Hoyer

Sub-stoichiometric inhibition of IAPP aggregation: a peptidomimetic approach to anti-amyloid agents

亚化学计量抑制 IAPP 聚集:一种抗淀粉样蛋白药物的肽模拟方法

Debabrata Maity, Sunil Kumar, Ruyof AlHussein, Lothar Gremer, Madeline Howarth, Laura Karpauskaite, Wolfgang Hoyer, Mazin Magzoub, Andrew D Hamilton

Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy

PI3-激酶 SH3 淀粉样蛋白原纤维的低温电子显微镜原子结构

Christine Röder, Nicola Vettore, Lena N Mangels, Lothar Gremer, Raimond B G Ravelli, Dieter Willbold, Wolfgang Hoyer, Alexander K Buell, Gunnar F Schröder