ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage.

ATM 和 DNA 依赖性蛋白激酶的催化亚基通过共同的 MEK/细胞外信号调节激酶/p90(rsk) 信号通路激活 NF-kappaB，以响应不同形式的 DNA 损伤