HER3 upregulation reduces DS-8201 sensitivity in HER2-positive tumor cells by ATR/CHK1/FoxO1 signaling cascade.
HER3 上调通过 ATR/CHK1/FoxO1 信号级联降低 HER2 阳性肿瘤细胞对 DS-8201 的敏感性。
期刊:Acta Pharmacologica Sinica
影响因子:8.4
doi:10.1038/s41401-025-01647-y
Li Wen-Jing, Kang Kai-Ge, Zhang Yu-Xiang, Zhao Xin-Xin, Zhu Xi, Tang Jiao, Li Yong-Peng, Fu Hao-Yu, Yao Qing, Wang Lei, Lou Li-Guang
细胞生物学
肿瘤细胞
ATR
CHK1
HER2
FOXO1
