日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

Author Correction: Combination of PARP and KRAS(G12D) inhibitors enhances therapeutic efficacy by exploiting vulnerabilities in PDAC

作者更正：PARP 和 KRAS(G12D) 抑制剂联合应用可通过利用 PDAC 的弱点来增强治疗效果。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-72371-2
Xu, Xin; Chen, Xin; Xu, Rongli; Huo, Zhenyu; Li, Changying; Nowsheen, Somaira; Aziz, Khaled; Yao, Fan; Lou, Zhenkun; Deng, Min
RAS
PARP
发表日期：2026
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Combination of PARP and KRAS(G12D) inhibitors enhances therapeutic efficacy by exploiting vulnerabilities in PDAC.

PARP 和 KRAS(G12D) 抑制剂的联合应用，利用 PDAC 的弱点，增强了治疗效果。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-026-69695-4
Xu Xin, Chen Xin, Xu Rongli, Huo Zhenyu, Li Changying, Nowsheen Somaira, Aziz Khaled, Yao Fan, Lou Zhenkun, Deng Min
RAS
PARP
发表日期：2026
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Correction: USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization

更正：USP20 通过 β-catenin 稳定作用正向调控肿瘤发生和化疗耐药性

期刊:Cell Death and Differentiation
影响因子:15.4
doi:10.1038/s41418-025-01593-6
Wu, Chenming; Luo, Kuntian; Zhao, Fei; Yin, Ping; Song, Ying; Deng, Min; Huang, Jinzhou; Chen, Yuping; Li, Lei; Lee, SeungBaek; Kim, JungJin; Zhou, Qin; Tu, Xinyi; Nowsheen, Somaira; Luo, Qifeng; Gao, Xiumei; Lou, Zhenkun; Liu, Zhongmin; Yuan, Jian
信号转导
肿瘤
肿瘤免疫
发表日期：2026
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Poly ADP Ribose Polymerase Inhibitors Potentiate Proton Therapy End-of-Range Effects by Accelerating Replication Forks and Promoting Transcription Conflict

聚ADP核糖聚合酶抑制剂通过加速复制叉和促进转录冲突来增强质子治疗的射程末端效应

期刊:International Journal of Radiation Oncology Biology Physics
影响因子:6.5
doi:10.1016/j.ijrobp.2025.08.049
Han, Yiqun; Zhou, Qin; Dibbs, Anna; Chen, Bin; Weiskittel, Taylor M; Remmes, Nicholas B; Wu, Zheming; Ebner, Daniel K; Kloeber, Jake A; Callaghan, Cameron M; Bendel, Anne E; Mullikin, Trey C; Laack, Nadia N; Xu-Welliver, Meng; Lou, Zhenkun; Mutter, Robert W
发表日期：2026
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Clinical Evidence on Particle Radiation, DNA Damage Response Inhibitors, and Immunotherapy for Mismatch Repair-Proficient Rectal Cancer

粒子放射治疗、DNA损伤反应抑制剂和免疫疗法治疗错配修复功能正常的直肠癌的临床证据

期刊:Cancers
影响因子:4.4
doi:10.3390/cancers18040652
Salazar-Vilches, Cristian J; Ebner, Daniel K; Kloeber, Jake A; Dragojevic, Sonja; Singh, Jasvinder; Haddock, Michael; Sharifzadeh, Yasamin; Sherry, Alexander D; Jethwa, Krishan R; Hallemeier, Christopher L; Merrell, Kenneth; Mutter, Robert W; Lou, Zhenkun; Callaghan, Cameron M
肿瘤
肠癌
肿瘤免疫
毒理研究
免疫/内分泌
发表日期：2026
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Increasing the Response of Mismatch Repair Proficient Rectal Cancer to Immunotherapy with Particle Radiation and DNA Damage Response Inhibitors-Preclinical Evidence

利用粒子放射和DNA损伤反应抑制剂增强错配修复功能正常的直肠癌对免疫疗法的反应——临床前证据

期刊:Cancers
影响因子:4.4
doi:10.3390/cancers18040682
Salazar-Vilches, Cristian J; Ebner, Daniel K; Kloeber, Jake A; Dragojevic, Sonja; Singh, Jasvinder; Haddock, Michael; Sharifzadeh, Yasamin; Sherry, Alexander D; Jethwa, Krishan R; Hallemeier, Christopher L; Merrell, Kenneth W; Mutter, Robert W; Lou, Zhenkun; Callaghan, Cameron M
肿瘤
肠癌
肿瘤免疫
毒理研究
免疫/内分泌
发表日期：2026
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KCTD10 as a selective cancer dependency from transcription-replication conflicts (TRCs)

KCTD10 作为一种选择性癌症依赖性，源于转录-复制冲突 (TRC)

期刊:
影响因子:
doi:10.70401/acrt.2026.0015
Kloeber, Jake A; Chen, Bin; Mutter, Robert; Huang, Jinzhou; Lou, Zhenkun
肿瘤
肿瘤免疫
发表日期：2026
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PAK1 inhibition synergistically enhances the anti-tumor efficacy of PARP inhibitors in ovarian cancers

PAK1抑制可协同增强PARP抑制剂在卵巢癌中的抗肿瘤疗效

期刊:Genes and Diseases
影响因子:
doi:10.1016/j.gendis.2025.101887
Li, Changying; Li, Xinyan; Gao, Ming; Deng, Min; Li, Ye-Xiong; Lou, Zhenkun
肿瘤
肿瘤免疫
PAK1
卵巢癌
PARP
发表日期：2026
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KCTD10 is a sensor for co-directional transcription-replication conflicts

KCTD10 是一种用于检测同向转录-复制冲突的传感器

期刊:Nature
影响因子:48.5
doi:10.1038/s41586-025-09585-9
Kloeber, Jake A; Chen, Bin; Sun, Guangchao; King, Charles S; Wang, Zhiquan; Wang, Li; Wu, Zheming; Zhu, Shouhai; Zhao, Fei; Qin, Hongran; Ouyang, Yaobin; Xiao, Huaping; Tu, Xinyi; Lu, Jing; Jiang, Yanxia; Luo, Kuntian; Yin, Ping; Wu, Xinyan; Mutter, Robert W; Huang, Jinzhou; Lou, Zhenkun
发表日期：2025
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Parkin deficiency promotes colorectal tumorigenesis and progression through RIPK3-dependent necroptotic inflammation

Parkin 缺陷通过 RIPK3 依赖性坏死性炎症促进结直肠肿瘤的发生和发展。

期刊:Cancer Communications
影响因子:24.9
doi:10.1002/cac2.12648
Wu, Zheming; Xiao, Huaping; Kloeber, Jake A; Ouyang, Yaobin; Yin, Ping; Huang, Jinzhou; Chen, Bin; Zhu, Shouhai; Lu, Jing; Han, Yiqun; Tu, Xinyi; Dragojevic, Sonja; Luo, Kuntian; Ting, Adrian T; Welliver, Meng; Lou, Zhenkun
RIPK3
肿瘤
炎症
肿瘤免疫
炎症/感染
Parkin
RIP
发表日期：2025
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