Lountos相关文献与解析，生知库 | 链接生命科学的每一步

Van, Cong T S; Reboul, Cyril F; Caesar, Joseph J E; Meana-Pañeda, Rubén; Lountos, George T; Deme, Justin C; Bryant, Owain J; Johnson, Steven; Piczak, Claire T; Valkov, Eugene; Lea, Susan M; Elmlund, Hans

MPL

发表日期：2025

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Targeted sulfur(VI) fluoride exchange-mediated covalent modification of a tyrosine residue in the catalytic pocket of tyrosyl-DNA phosphodiesterase 1

靶向硫（VI）氟化物交换介导的酪氨酰-DNA磷酸二酯酶1催化口袋中酪氨酸残基的共价修饰

期刊:Communications Chemistry

影响因子:5.9

doi:10.1038/s42004-024-01298-w

Xue Zhi Zhao, Idris A Barakat, George T Lountos, Wenjie Wang, Keli Agama, Md Rasel Al Mahmud, Kiall F Suazo, Thorkell Andresson, Yves Pommier, Terrence R Burke Jr

信号转导

发表日期：2024

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P1' specificity of the S219V/R203G mutant tobacco etch virus protease

S219V/R203G突变型烟草蚀纹病毒蛋白酶的P1'特异性

期刊:Proteins-Structure Function and Bioinformatics

影响因子:2.8

doi:10.1002/prot.26693

Golda, Mária; Hoffka, Gyula; Cherry, Scott; Tropea, Joseph E; Lountos, George T; Waugh, David S; Wlodawer, Alexander; Tőzsér, József; Mótyán, János András

微生物学

发表日期：2024

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Self-inhibited State of Venezuelan Equine Encephalitis Virus (VEEV) nsP2 Cysteine Protease: A Crystallographic and Molecular Dynamics Analysis

委内瑞拉马脑炎病毒（VEEV）nsP2半胱氨酸蛋白酶的自身抑制状态：晶体学和分子动力学分析

期刊:Journal of Molecular Biology

影响因子:4.5

doi:10.1016/j.jmb.2023.168012

Hoffka, Gyula; Lountos, George T; Needle, Danielle; Wlodawer, Alexander; Waugh, David S; Tőzsér, József; Mótyán, János András

Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification

通过肟类化合物多样化鉴定可同时作用于DNA、蛋白质和催化结合位点的多齿酪氨酰-DNA磷酸二酯酶1 (TDP1) 抑制剂

期刊:RSC Chemical Biology

影响因子:3.1

doi:10.1039/d2cb00230b

Zhao, Xue Zhi; Wang, Wenjie; Lountos, George T; Kiselev, Evgeny; Tropea, Joseph E; Needle, Danielle; Pommier, Yves; Burke, Terrence R Jr

发表日期：2023

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Unique Structural Fold of LonBA Protease from Bacillus subtilis, a Member of a Newly Identified Subfamily of Lon Proteases

枯草芽孢杆菌中 LonBA 蛋白酶的独特结构折叠，该蛋白酶是新发现的 Lon 蛋白酶亚家族的成员

期刊:International Journal of Molecular Sciences

影响因子:0.7

doi:10.3390/ijms231911425

Alla Gustchina, Mi Li, Anna G Andrianova, Arsen M Kudzhaev, George T Lountos, Bartosz Sekula, Scott Cherry, Joseph E Tropea, Ivan V Smirnov, Alexander Wlodawer, Tatyana V Rotanova

免疫

发表日期：2022

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Characterization of a broadly specific cadaverine N-hydroxylase involved in desferrioxamine B biosynthesis in Streptomyces sviceus

参与链霉菌中去铁胺 B 生物合成的广谱戊二胺 N-羟化酶的表征

期刊:PLoS One

影响因子:2.9

doi:10.1371/journal.pone.0248385

Lesley-Ann Giddings, George T Lountos, Kang Woo Kim, Matthew Brockley, Danielle Needle, Scott Cherry, Joseph E Tropea, David S Waugh

YES

发表日期：2021

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Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening

通过晶体碎片鸡尾酒筛选鉴定配体结合热点和复制酪氨酰-DNA 磷酸二酯酶 I (TDP1) 磷酸基识别的结构基序

期刊:Nucleic Acids Research

影响因子:16.6

doi:10.1093/nar/gkz515

George T Lountos, Xue Zhi Zhao, Evgeny Kiselev, Joseph E Tropea, Danielle Needle, Yves Pommier, Terrence R Burke, David S Waugh

发表日期：2019

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Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery

冷冻电镜解析无底物大肠杆菌Lon蛋白酶的结构，揭示了Lon蛋白酶机制的动态变化。

期刊:Current Research in Structural Biology

影响因子:2.5

doi:10.1016/j.crstbi.2019.10.001

Botos, Istvan; Lountos, George T; Wu, Weimin; Cherry, Scott; Ghirlando, Rodolfo; Kudzhaev, Arsen M; Rotanova, Tatyana V; de Val, Natalia; Tropea, Joseph E; Gustchina, Alla; Wlodawer, Alexander

发表日期：2019

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Potent Î²-lactam-based tyrosyl-DNA phosphodiesterase 1 inhibitors identified by a virtual screen.

通过虚拟筛选鉴定出强效β-内酰胺类酪氨酰-DNA磷酸二酯酶1抑制剂

Probabilistic single-particle cryo-EM ab initio 3D reconstruction in SIMPLE

SIMPLE 中的概率单颗粒冷冻电镜从头算三维重建

Targeted sulfur(VI) fluoride exchange-mediated covalent modification of a tyrosine residue in the catalytic pocket of tyrosyl-DNA phosphodiesterase 1

靶向硫（VI）氟化物交换介导的酪氨酰-DNA磷酸二酯酶1催化口袋中酪氨酸残基的共价修饰

P1' specificity of the S219V/R203G mutant tobacco etch virus protease

S219V/R203G突变型烟草蚀纹病毒蛋白酶的P1'特异性

Self-inhibited State of Venezuelan Equine Encephalitis Virus (VEEV) nsP2 Cysteine Protease: A Crystallographic and Molecular Dynamics Analysis

委内瑞拉马脑炎病毒（VEEV）nsP2半胱氨酸蛋白酶的自身抑制状态：晶体学和分子动力学分析

Identification of multidentate tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors that simultaneously access the DNA, protein and catalytic-binding sites by oxime diversification

通过肟类化合物多样化鉴定可同时作用于DNA、蛋白质和催化结合位点的多齿酪氨酰-DNA磷酸二酯酶1 (TDP1) 抑制剂

Unique Structural Fold of LonBA Protease from Bacillus subtilis, a Member of a Newly Identified Subfamily of Lon Proteases

枯草芽孢杆菌中 LonBA 蛋白酶的独特结构折叠，该蛋白酶是新发现的 Lon 蛋白酶亚家族的成员

Characterization of a broadly specific cadaverine N-hydroxylase involved in desferrioxamine B biosynthesis in Streptomyces sviceus

参与链霉菌中去铁胺 B 生物合成的广谱戊二胺 N-羟化酶的表征

Identification of a ligand binding hot spot and structural motifs replicating aspects of tyrosyl-DNA phosphodiesterase I (TDP1) phosphoryl recognition by crystallographic fragment cocktail screening

通过晶体碎片鸡尾酒筛选鉴定配体结合热点和复制酪氨酰-DNA 磷酸二酯酶 I (TDP1) 磷酸基识别的结构基序

Cryo-EM structure of substrate-free E. coli Lon protease provides insights into the dynamics of Lon machinery

冷冻电镜解析无底物大肠杆菌Lon蛋白酶的结构，揭示了Lon蛋白酶机制的动态变化。