PD-1 blockade during T cell priming enhances long-term protection against metastatic tumors by epigenetically tuning T cell exhaustion
在T细胞启动过程中阻断PD-1可通过表观遗传调控T细胞耗竭,增强对转移性肿瘤的长期保护作用。
期刊:
影响因子:
doi:10.1101/2025.11.25.690601
Dinter, Teresa; Mackowiak, Sebastian; Rogers, Zachary J; Bhandarkar, Vidit; Carney, Molly Y; Zhang, Yiming J; Morgan, Duncan; Pop, Lorelai; Chatterjee, Fiona; Lutz, Emi; Jain, Yajit; Radhakrishnan, Adityanarayanan; Lander, Eric; Dane Wittrup, K; Love, J Christopher; Meissner, Alexander; Spranger, Stefani
肿瘤
表观遗传
T细胞
肿瘤免疫
信号转导
T细胞
细胞生物学
PD-1
免疫/内分泌