日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

MK-7602: a potent multi-stage dual-targeting antimalarial

MK-7602:一种强效的多阶段双靶点抗疟药

Favuzza, Paola; Palandri, Josephine; de Lera Ruiz, Manuel; Bailey, Wendy; Boyce, Christopher W; Danziger, Andrew; Fawaz, Maria V; Kelly, Michael; Murgolo, Nicholas; Robbins, Jonathan A; Vavrek, Marissa; Zhao, Lianyun; Lei, Zhiyu; Guo, Zhuyan; Reaksudsan, Kitsanapong; Steel, Ryan W J; Hodder, Anthony N; Ngo, Anna; Dziekan, Jerzy M; Thompson, Jennifer K; Triglia, Tony; Birkinshaw, Richard W; Penington, Jocelyn Sietsma; Scally, Stephen W; Dans, Madeline G; Coyle, Rachael; Sevilleno, Nicole; Orban, Agnes; Feufack-Donfack, Lionel Brice; Popovici, Jean; Lee, Marcus C S; Papenfuss, Anthony; Lowes, Kym N; Sleebs, Brad E; McCarthy, James S; McCauley, John A; Boddey, Justin A; Olsen, David B; Cowman, Alan F

A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID.

一种新型PLpro抑制剂改善了新冠肺炎长期症状的临床前模型的结果

M Bader Stefanie, Calleja Dale J, Devine Shane M, Kuchel Nathan W, Lu Bernadine G C, Wu Xinyu, Birkinshaw Richard W, Bhandari Reet, Loi Katie, Volpe Rohan, Khakham Yelena, Au Amanda E, Blackmore Timothy R, Mackiewicz Liana, Dayton Merle, Schaefer Jan, Scherer Lena, Stock Angus T, Cooney James P, Schoffer Kael, Maluenda Ana, Kleeman Elizabeth A, Davidson Kathryn C, Allison Cody C, Ebert Gregor, Chen Gong, Katneni Kasiram, Klemm Theresa A, Nachbur Ueli, Georgy Smitha Rose, Czabotar Peter E, Hannan Anthony J, Putoczki Tracy L, Tanzer Maria, Pellegrini Marc, Lechtenberg Bernhard C, Charman Susan A, Call Melissa J, Mitchell Jeffrey P, Lowes Kym N, Lessene Guillaume, Doerflinger Marcel, Komander David

Optimization of 2,3-Dihydroquinazolinone-3-carboxamides as Antimalarials Targeting PfATP4

优化 2,3-二氢喹唑啉酮-3-甲酰胺类化合物作为靶向 PfATP4 的抗疟药

Ashton, Trent D; Dans, Madeline G; Favuzza, Paola; Ngo, Anna; Lehane, Adele M; Zhang, Xinxin; Qiu, Deyun; Chandra Maity, Bikash; De, Nirupam; Schindler, Kyra A; Yeo, Tomas; Park, Heekuk; Uhlemann, Anne-Catrin; Churchyard, Alisje; Baum, Jake; Fidock, David A; Jarman, Kate E; Lowes, Kym N; Baud, Delphine; Brand, Stephen; Jackson, Paul F; Cowman, Alan F; Sleebs, Brad E

RH5.1-CyRPA-Ripr antigen combination vaccine shows little improvement over RH5.1 in a preclinical setting

在临床前研究中,RH5.1-CyRPA-Ripr抗原组合疫苗与RH5.1相比,疗效提升甚微。

Healer, Julie; Thompson, Jennifer K; Mackwell, Karen L; Browne, Cecille D; Seager, Benjamin A; Ngo, Anna; Lowes, Kym N; Silk, Sarah E; Pulido, David; King, Lloyd D W; Christen, Jayne M; Noe, Amy R; Kotraiah, Vinayaka; Masendycz, Paul J; Rajagopalan, Rajkannan; Lucas, Leanne; Stanford, Marianne M; Soisson, Lorraine; Diggs, Carter; Miller, Robin; Youll, Susan; Wycherley, Kaye; Draper, Simon J; Cowman, Alan F

Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites

抑制疟原虫蛋白酶V的活性表明其在蛋白质输出、PfEMP1展示和疟原虫存活中起着至关重要的作用。

Sleebs, Brad E; Lopaticki, Sash; Marapana, Danushka S; O'Neill, Matthew T; Rajasekaran, Pravin; Gazdik, Michelle; Günther, Svenja; Whitehead, Lachlan W; Lowes, Kym N; Barfod, Lea; Hviid, Lars; Shaw, Philip J; Hodder, Anthony N; Smith, Brian J; Cowman, Alan F; Boddey, Justin A

betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis.

betaTrCP 和 Rsk1/2 介导的 BimEL 降解抑制细胞凋亡

Dehan Elinor, Bassermann Florian, Guardavaccaro Daniele, Vasiliver-Shamis Gaia, Cohen Michael, Lowes Kym N, Dustin Michael, Huang David C S, Taunton Jack, Pagano Michele